Short-term association between outdoor temperature and the hydration-marker copeptin : a pooled analysis in five cohorts
(2023) In EBioMedicine 95.- Abstract
BACKGROUND: Whereas outdoor temperature is linked to both mortality and hydration status, the hormone vasopressin, measured through the surrogate copeptin, is a marker of cardiometabolic risk and hydration. We recently showed that copeptin has a seasonal pattern with higher plasma concentration in winter. Here, we aimed to investigate the association between outdoor temperature and copeptin.
METHODS: Copeptin was analysed in fasting plasma from five cohorts in Malmö, Sweden (n = 26,753, 49.7% men, age 18-86 years). We utilized a multivariable adjusted non-linear spline model with four knots to investigate the association between short-term temperature (24 h mean apparent) and log copeptin z-score.
FINDINGS: We found a... (More)
BACKGROUND: Whereas outdoor temperature is linked to both mortality and hydration status, the hormone vasopressin, measured through the surrogate copeptin, is a marker of cardiometabolic risk and hydration. We recently showed that copeptin has a seasonal pattern with higher plasma concentration in winter. Here, we aimed to investigate the association between outdoor temperature and copeptin.
METHODS: Copeptin was analysed in fasting plasma from five cohorts in Malmö, Sweden (n = 26,753, 49.7% men, age 18-86 years). We utilized a multivariable adjusted non-linear spline model with four knots to investigate the association between short-term temperature (24 h mean apparent) and log copeptin z-score.
FINDINGS: We found a distinct non-linear association between temperature and log copeptin z-score, with both moderately low and high temperatures linked to higher copeptin concentration (p < 0.0001). Between 0 °C and nadir at the 75th temperature percentile (corresponding to 14.3 °C), log copeptin decreased 0.13 z-scores (95% CI 0.096; 0.16), which also inversely corresponded to the increase in z-score log copeptin between the nadir and 21.3 °C.
INTERPRETATION: The J-shaped association between short-term temperature and copeptin resembles the J-shaped association between temperature and mortality. Whereas the untangling of temperature from other seasonal effects on hydration warrants further study, moderately increased water intake constitutes a feasible intervention to lower vasopressin and might mitigate adverse health effects of both moderately cold and hot outdoor temperatures.
FUNDING: Swedish Research Council, Å Wiberg, M Stephen, A Påhlsson, Crafoord and Swedish Heart-Lung Foundations, Swedish Society for Medical Research and Swedish Society of Medicine.
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- author
- Timpka, Simon LU ; Melander, Olle LU ; Engström, Gunnar LU ; Elmståhl, Sölve LU ; Nilsson, Peter M LU ; Lind, Lars ; Pihlsgård, Mats LU and Enhörning, Sofia LU
- organization
-
- Perinatal and cardiovascular epidemiology (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- EpiHealth: Epidemiology for Health
- Department of Clinical Sciences, Malmö
- LUDC (Lund University Diabetes Centre)-lup-obsolete (research group)
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- Geriatrics (research group)
- Internal Medicine - Epidemiology (research group)
- publishing date
- 2023-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Young Adult, Biomarkers/blood, Glycopeptides/blood, Temperature, Vasopressins/blood, Seasons, Hot Temperature, Cold Temperature
- in
- EBioMedicine
- volume
- 95
- article number
- 104750
- pages
- 8 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:37556945
- scopus:85166928927
- ISSN
- 2352-3964
- DOI
- 10.1016/j.ebiom.2023.104750
- language
- English
- LU publication?
- yes
- additional info
- Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
- id
- 2f6ede7b-49b9-40d0-9b73-06b527a81819
- date added to LUP
- 2023-10-10 12:36:15
- date last changed
- 2024-06-28 08:37:49
@article{2f6ede7b-49b9-40d0-9b73-06b527a81819, abstract = {{<p>BACKGROUND: Whereas outdoor temperature is linked to both mortality and hydration status, the hormone vasopressin, measured through the surrogate copeptin, is a marker of cardiometabolic risk and hydration. We recently showed that copeptin has a seasonal pattern with higher plasma concentration in winter. Here, we aimed to investigate the association between outdoor temperature and copeptin.</p><p>METHODS: Copeptin was analysed in fasting plasma from five cohorts in Malmö, Sweden (n = 26,753, 49.7% men, age 18-86 years). We utilized a multivariable adjusted non-linear spline model with four knots to investigate the association between short-term temperature (24 h mean apparent) and log copeptin z-score.</p><p>FINDINGS: We found a distinct non-linear association between temperature and log copeptin z-score, with both moderately low and high temperatures linked to higher copeptin concentration (p < 0.0001). Between 0 °C and nadir at the 75th temperature percentile (corresponding to 14.3 °C), log copeptin decreased 0.13 z-scores (95% CI 0.096; 0.16), which also inversely corresponded to the increase in z-score log copeptin between the nadir and 21.3 °C.</p><p>INTERPRETATION: The J-shaped association between short-term temperature and copeptin resembles the J-shaped association between temperature and mortality. Whereas the untangling of temperature from other seasonal effects on hydration warrants further study, moderately increased water intake constitutes a feasible intervention to lower vasopressin and might mitigate adverse health effects of both moderately cold and hot outdoor temperatures.</p><p>FUNDING: Swedish Research Council, Å Wiberg, M Stephen, A Påhlsson, Crafoord and Swedish Heart-Lung Foundations, Swedish Society for Medical Research and Swedish Society of Medicine.</p>}}, author = {{Timpka, Simon and Melander, Olle and Engström, Gunnar and Elmståhl, Sölve and Nilsson, Peter M and Lind, Lars and Pihlsgård, Mats and Enhörning, Sofia}}, issn = {{2352-3964}}, keywords = {{Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Young Adult; Biomarkers/blood; Glycopeptides/blood; Temperature; Vasopressins/blood; Seasons; Hot Temperature; Cold Temperature}}, language = {{eng}}, publisher = {{Elsevier}}, series = {{EBioMedicine}}, title = {{Short-term association between outdoor temperature and the hydration-marker copeptin : a pooled analysis in five cohorts}}, url = {{http://dx.doi.org/10.1016/j.ebiom.2023.104750}}, doi = {{10.1016/j.ebiom.2023.104750}}, volume = {{95}}, year = {{2023}}, }