Sex-specific interactions between the IRS1 polymorphism and intakes of carbohydrates and fat on incident type 2 diabetes.
(2012) In The American journal of clinical nutrition- Abstract
- BACKGROUND: The minor T allele of rs2943641 near the gene encoding for insulin receptor substrate 1 (IRS1) has been associated with decreased risk of type 2 diabetes (T2D) and adiposity in genome-wide association studies. Dietary intake can influence the regulation of IRS1, and studies have indicated sex-specific associations between IRS1 and adiposity. OBJECTIVE: The objective was to examine the interaction between IRS1 rs2943641 and macronutrient intakes on incident T2D and percentage body fat in the Malmö Diet and Cancer cohort. DESIGN: The study included 15,227 women and 9614 men aged 45-74 y without prevalent diabetes. Dietary data were collected with a modified diet history method. During 12 y follow-up, 1567 incident T2D cases were... (More)
- BACKGROUND: The minor T allele of rs2943641 near the gene encoding for insulin receptor substrate 1 (IRS1) has been associated with decreased risk of type 2 diabetes (T2D) and adiposity in genome-wide association studies. Dietary intake can influence the regulation of IRS1, and studies have indicated sex-specific associations between IRS1 and adiposity. OBJECTIVE: The objective was to examine the interaction between IRS1 rs2943641 and macronutrient intakes on incident T2D and percentage body fat in the Malmö Diet and Cancer cohort. DESIGN: The study included 15,227 women and 9614 men aged 45-74 y without prevalent diabetes. Dietary data were collected with a modified diet history method. During 12 y follow-up, 1567 incident T2D cases were identified. RESULTS: The T allele was associated with lower incidence of T2D (P-trend = 0.003) and, in men, with higher percentage body fat (P-trend = 0.00002). We observed 3-way interactions between sex, rs2943641, and carbohydrate intake (P = 0.01) as well as between sex, rs2943641, and fat intake (P = 0.01) on incident T2D. Among women, the T allele was associated with decreased risk only in the lower tertiles of carbohydrate intake (P-trend = 0.01, P-interaction = 0.01). In contrast, among men, the T allele was associated with decreased risk in the lowest tertile of fat intake (P-trend = 0.01, P-interaction = 0.02). No interaction was observed between macronutrient intakes and rs2943641 on percentage body fat. CONCLUSIONS: Our results indicate that IRS1 rs2943641 interacts with carbohydrate and fat intakes on incident T2D in a sex-specific fashion. A protective association between the rs2943641 T allele and T2D was restricted to women with low carbohydrate intake and to men with low fat intake. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3347468
- author
- Ericson, Ulrika LU ; Rukh, Gull LU ; Stojkovic, Ivana LU ; Sonestedt, Emily LU ; Gullberg, Bo LU ; Wirfält, Elisabet LU ; Wallström, Peter LU and Orho-Melander, Marju LU
- organization
- publishing date
- 2012-12-05
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The American journal of clinical nutrition
- publisher
- Oxford University Press
- external identifiers
-
- wos:000313135600027
- pmid:23221578
- scopus:84871985425
- pmid:23221578
- ISSN
- 1938-3207
- DOI
- 10.3945/ajcn.112.046474
- language
- English
- LU publication?
- yes
- id
- 89074868-4444-4ba2-bf65-f090ac790f6e (old id 3347468)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23221578?dopt=Abstract
- date added to LUP
- 2016-04-04 09:22:27
- date last changed
- 2022-03-15 18:58:11
@article{89074868-4444-4ba2-bf65-f090ac790f6e, abstract = {{BACKGROUND: The minor T allele of rs2943641 near the gene encoding for insulin receptor substrate 1 (IRS1) has been associated with decreased risk of type 2 diabetes (T2D) and adiposity in genome-wide association studies. Dietary intake can influence the regulation of IRS1, and studies have indicated sex-specific associations between IRS1 and adiposity. OBJECTIVE: The objective was to examine the interaction between IRS1 rs2943641 and macronutrient intakes on incident T2D and percentage body fat in the Malmö Diet and Cancer cohort. DESIGN: The study included 15,227 women and 9614 men aged 45-74 y without prevalent diabetes. Dietary data were collected with a modified diet history method. During 12 y follow-up, 1567 incident T2D cases were identified. RESULTS: The T allele was associated with lower incidence of T2D (P-trend = 0.003) and, in men, with higher percentage body fat (P-trend = 0.00002). We observed 3-way interactions between sex, rs2943641, and carbohydrate intake (P = 0.01) as well as between sex, rs2943641, and fat intake (P = 0.01) on incident T2D. Among women, the T allele was associated with decreased risk only in the lower tertiles of carbohydrate intake (P-trend = 0.01, P-interaction = 0.01). In contrast, among men, the T allele was associated with decreased risk in the lowest tertile of fat intake (P-trend = 0.01, P-interaction = 0.02). No interaction was observed between macronutrient intakes and rs2943641 on percentage body fat. CONCLUSIONS: Our results indicate that IRS1 rs2943641 interacts with carbohydrate and fat intakes on incident T2D in a sex-specific fashion. A protective association between the rs2943641 T allele and T2D was restricted to women with low carbohydrate intake and to men with low fat intake.}}, author = {{Ericson, Ulrika and Rukh, Gull and Stojkovic, Ivana and Sonestedt, Emily and Gullberg, Bo and Wirfält, Elisabet and Wallström, Peter and Orho-Melander, Marju}}, issn = {{1938-3207}}, language = {{eng}}, month = {{12}}, publisher = {{Oxford University Press}}, series = {{The American journal of clinical nutrition}}, title = {{Sex-specific interactions between the IRS1 polymorphism and intakes of carbohydrates and fat on incident type 2 diabetes.}}, url = {{http://dx.doi.org/10.3945/ajcn.112.046474}}, doi = {{10.3945/ajcn.112.046474}}, year = {{2012}}, }