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Fasting serum concentration of short-chain fatty acids in subjects with microscopic colitis and celiac disease: no difference compared with controls, but between genders.

Jakobsdottir, Greta LU ; Bjerregaard, Jens Holst ; Skovbjerg, Hanne and Nyman, Margareta LU (2013) In Scandinavian Journal of Gastroenterology 48(6). p.696-701
Abstract
Abstract Background. Short-chain fatty acids (SCFAs), particularly propionic and butyric acids, have been shown to have many positive health effects. The amount and type of SCFAs formed from dietary fibre by the colonic microbiota depends on the substrate available and is reflected in blood. The total intake and type of dietary fibre in people with gastrointestinal diseases differs considerably from healthy subjects. Objective. To compare fasting SCFA concentrations in subjects with microscopic colitis (MC), celiac disease and controls without these diseases. SCFAs were also analysed over 6.5 h in young healthy subjects, who had eaten a fibre-rich breakfast, to identify a possible peak concentration of SCFAs after a meal. Methods. SCFAs in... (More)
Abstract Background. Short-chain fatty acids (SCFAs), particularly propionic and butyric acids, have been shown to have many positive health effects. The amount and type of SCFAs formed from dietary fibre by the colonic microbiota depends on the substrate available and is reflected in blood. The total intake and type of dietary fibre in people with gastrointestinal diseases differs considerably from healthy subjects. Objective. To compare fasting SCFA concentrations in subjects with microscopic colitis (MC), celiac disease and controls without these diseases. SCFAs were also analysed over 6.5 h in young healthy subjects, who had eaten a fibre-rich breakfast, to identify a possible peak concentration of SCFAs after a meal. Methods. SCFAs in serum were pre-concentrated using hollow fibre-supported liquid membrane extraction and gas chromatography. Results. The MC group had a higher concentration of valeric acid than the control group (p < 0.01). No significant differences in other SCFA concentrations were seen between groups, but the control group tended to have higher concentration of acetic acid (p = 0.1). Furthermore, males had higher concentrations of SCFAs (with the exception of valeric acid) than females (p < 0.05), which were independent of groups. The peaks for acetic, propionic and butyric acids came approximately 5 h, 6.5 h and 2-3 h, respectively, after breakfast. Conclusion. The fasting concentrations of SCFAs were quite similar, although the fibre intake had probably been quite different for a long time. The results might have been different if SCFAs had been recorded over a longer period. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Gastroenterology
volume
48
issue
6
pages
696 - 701
publisher
Taylor & Francis
external identifiers
  • wos:000319512500008
  • pmid:23600961
  • scopus:84878452354
  • pmid:23600961
ISSN
1502-7708
DOI
10.3109/00365521.2013.786128
project
ANTIDIABETIC FOOD CENTRE
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Applied Nutrition and Food Chemistry (011001300)
id
ee6c578a-9383-41ff-807c-6c9a88c40db4 (old id 3733571)
date added to LUP
2016-04-01 10:14:32
date last changed
2023-11-09 15:37:03
@article{ee6c578a-9383-41ff-807c-6c9a88c40db4,
  abstract     = {{Abstract Background. Short-chain fatty acids (SCFAs), particularly propionic and butyric acids, have been shown to have many positive health effects. The amount and type of SCFAs formed from dietary fibre by the colonic microbiota depends on the substrate available and is reflected in blood. The total intake and type of dietary fibre in people with gastrointestinal diseases differs considerably from healthy subjects. Objective. To compare fasting SCFA concentrations in subjects with microscopic colitis (MC), celiac disease and controls without these diseases. SCFAs were also analysed over 6.5 h in young healthy subjects, who had eaten a fibre-rich breakfast, to identify a possible peak concentration of SCFAs after a meal. Methods. SCFAs in serum were pre-concentrated using hollow fibre-supported liquid membrane extraction and gas chromatography. Results. The MC group had a higher concentration of valeric acid than the control group (p &lt; 0.01). No significant differences in other SCFA concentrations were seen between groups, but the control group tended to have higher concentration of acetic acid (p = 0.1). Furthermore, males had higher concentrations of SCFAs (with the exception of valeric acid) than females (p &lt; 0.05), which were independent of groups. The peaks for acetic, propionic and butyric acids came approximately 5 h, 6.5 h and 2-3 h, respectively, after breakfast. Conclusion. The fasting concentrations of SCFAs were quite similar, although the fibre intake had probably been quite different for a long time. The results might have been different if SCFAs had been recorded over a longer period.}},
  author       = {{Jakobsdottir, Greta and Bjerregaard, Jens Holst and Skovbjerg, Hanne and Nyman, Margareta}},
  issn         = {{1502-7708}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{696--701}},
  publisher    = {{Taylor & Francis}},
  series       = {{Scandinavian Journal of Gastroenterology}},
  title        = {{Fasting serum concentration of short-chain fatty acids in subjects with microscopic colitis and celiac disease: no difference compared with controls, but between genders.}},
  url          = {{http://dx.doi.org/10.3109/00365521.2013.786128}},
  doi          = {{10.3109/00365521.2013.786128}},
  volume       = {{48}},
  year         = {{2013}},
}