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Immunohistochemistry in the differential diagnostics of primary lung cancer: an investigation within the southern Swedish lung cancer study.

Brunnström, Hans LU orcid ; Johansson, Leif LU ; Jirström, Karin LU orcid ; Jönsson, Mats LU ; Jönsson, Per LU and Planck, Maria LU (2013) In American Journal of Clinical Pathology 140(1). p.37-46
Abstract
Objectives: To assess immunohistochemical (IHC) stains differentially expressed between different types of lung cancer. Methods: We evaluated 16 different IHC stains in 209 prospectively included, surgically treated primary lung cancers, including 121 adenocarcinomas, 65 squamous cell carcinomas, 15 large-cell carcinomas, 5 adenosquamous carcinomas, 2 sarcomatoid carcinomas, and 1 small-cell carcinoma, using the tissue microarray technique. Results: Cytokeratin 5 (CK5) and P63 were both positive in 10% or more of the cells in 97% of the squamous cell carcinomas, with the former being positive (<10% of the cells) in only 2 non-squamous cell carcinomas. Thyroid transcription factor 1 (TTF1) and napsin A were positive in 10% or more of the... (More)
Objectives: To assess immunohistochemical (IHC) stains differentially expressed between different types of lung cancer. Methods: We evaluated 16 different IHC stains in 209 prospectively included, surgically treated primary lung cancers, including 121 adenocarcinomas, 65 squamous cell carcinomas, 15 large-cell carcinomas, 5 adenosquamous carcinomas, 2 sarcomatoid carcinomas, and 1 small-cell carcinoma, using the tissue microarray technique. Results: Cytokeratin 5 (CK5) and P63 were both positive in 10% or more of the cells in 97% of the squamous cell carcinomas, with the former being positive (<10% of the cells) in only 2 non-squamous cell carcinomas. Thyroid transcription factor 1 (TTF1) and napsin A were positive in 10% or more of the cells in 88% and 87% of the adenocarcinomas, respectively, with 94% of the adenocarcinomas being positive in at least 1 marker. Fifteen percent of the adenocarcinomas were positive for estrogen receptor. Conclusions: CK5, TTF1, and napsin A are sensitive markers for squamous cell carcinoma and adenocarcinoma of the lung. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
American Journal of Clinical Pathology
volume
140
issue
1
pages
37 - 46
publisher
Oxford University Press
external identifiers
  • wos:000320634100004
  • pmid:23765532
  • scopus:84879423454
  • pmid:23765532
ISSN
1943-7722
DOI
10.1309/AJCP50RDXSCSBTBO
project
Histopathological and molecular diagnostics of lung cancer
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Thoracic Surgery (013230027), Oncology, MV (013035000)
id
19b84a19-e420-4bbe-8438-9d864a444fcf (old id 3913386)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23765532?dopt=Abstract
date added to LUP
2016-04-01 10:30:53
date last changed
2024-01-06 18:38:58
@article{19b84a19-e420-4bbe-8438-9d864a444fcf,
  abstract     = {{Objectives: To assess immunohistochemical (IHC) stains differentially expressed between different types of lung cancer. Methods: We evaluated 16 different IHC stains in 209 prospectively included, surgically treated primary lung cancers, including 121 adenocarcinomas, 65 squamous cell carcinomas, 15 large-cell carcinomas, 5 adenosquamous carcinomas, 2 sarcomatoid carcinomas, and 1 small-cell carcinoma, using the tissue microarray technique. Results: Cytokeratin 5 (CK5) and P63 were both positive in 10% or more of the cells in 97% of the squamous cell carcinomas, with the former being positive (&lt;10% of the cells) in only 2 non-squamous cell carcinomas. Thyroid transcription factor 1 (TTF1) and napsin A were positive in 10% or more of the cells in 88% and 87% of the adenocarcinomas, respectively, with 94% of the adenocarcinomas being positive in at least 1 marker. Fifteen percent of the adenocarcinomas were positive for estrogen receptor. Conclusions: CK5, TTF1, and napsin A are sensitive markers for squamous cell carcinoma and adenocarcinoma of the lung.}},
  author       = {{Brunnström, Hans and Johansson, Leif and Jirström, Karin and Jönsson, Mats and Jönsson, Per and Planck, Maria}},
  issn         = {{1943-7722}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{37--46}},
  publisher    = {{Oxford University Press}},
  series       = {{American Journal of Clinical Pathology}},
  title        = {{Immunohistochemistry in the differential diagnostics of primary lung cancer: an investigation within the southern Swedish lung cancer study.}},
  url          = {{http://dx.doi.org/10.1309/AJCP50RDXSCSBTBO}},
  doi          = {{10.1309/AJCP50RDXSCSBTBO}},
  volume       = {{140}},
  year         = {{2013}},
}