Predominance of caudate nucleus lesions in acute ischemic stroke patients with impairments in language and speech
Grönholm, Erik ; Roll, Mikael LU ; Horne, Merle LU
; Sundgren, Pia
LU
and Lindgren, Arne
LU
(2016)
In European Journal of Neurology
23(1).
p.148-153
- Abstract
- Background and purpose. Whereas traditional views of language processing in the brain have assumed that the language function is concentrated to a limited number of cortical areas (Broca’s and Wernicke’s areas), current knowledge points at a much more complex system of language and speech processing involving many brain areas, both cortical and subcortical. The purpose of the current study was to make an unbiased assessment of which cerebral areas are affected in first-ever acute ischemic stroke patients identified as having language and speech impairments according to the National Institute of Health Stroke Scale (NIHSS).
Methods. Data from thirty-four patients with language and speech impairments, with a score of 1-3 on item 9... (More) - Background and purpose. Whereas traditional views of language processing in the brain have assumed that the language function is concentrated to a limited number of cortical areas (Broca’s and Wernicke’s areas), current knowledge points at a much more complex system of language and speech processing involving many brain areas, both cortical and subcortical. The purpose of the current study was to make an unbiased assessment of which cerebral areas are affected in first-ever acute ischemic stroke patients identified as having language and speech impairments according to the National Institute of Health Stroke Scale (NIHSS).
Methods. Data from thirty-four patients with language and speech impairments, with a score of 1-3 on item 9 on the NIHSS, following ischemic stroke was collected from the Lund Stroke Register. MRI images acquired up to 20 days after stroke onset were used to create an overlap lesion image using MRIcron software.
Results. The classical language areas, Wernicke’s and Broca’s area, were affected in less than one fourth of the patients. The most frequently affected region was a subcortical region - the left caudate nucleus and the adjacent corona radiata.
Conclusions. These findings contribute to the growing body of evidence that the basal ganglia have a crucial role in the control over language and speech processing. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4253258
- author
- Grönholm, Erik
; Roll, Mikael
LU
; Horne, Merle
LU
; Sundgren, Pia
LU
and Lindgren, Arne
LU
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- caudate nucleus, stroke, speech, language, MRI, basal ganglia
- in
- European Journal of Neurology
- volume
- 23
- issue
- 1
- pages
- 148 - 153
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000368238700022
- scopus:84955212299
- pmid:26268364
- pmid:26268364
- ISSN
- 1351-5101
- DOI
- 10.1111/ene.12822
- project
- Humanities and Medicine (HuMe)
- Images of tones: fMRI-studies on the processing of prosody in the human brain
- language
- English
- LU publication?
- yes
- additional info
- Article first published online: 12 AUG 2015. The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Diagnostic Radiology, (Lund) (013038000), Neurology, Lund (013027000), Clinical Strike Research Group (013027200), Linguistics and Phonetics (015010003)
- id
- 69bd5ae0-13e8-4e97-bb66-8ffaed787c21 (old id 4253258)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26268364?dopt=Abstract
- date added to LUP
- 2016-04-01 10:14:47
- date last changed
- 2023-11-09 15:53:52
@article{69bd5ae0-13e8-4e97-bb66-8ffaed787c21,
abstract = {{Background and purpose. Whereas traditional views of language processing in the brain have assumed that the language function is concentrated to a limited number of cortical areas (Broca’s and Wernicke’s areas), current knowledge points at a much more complex system of language and speech processing involving many brain areas, both cortical and subcortical. The purpose of the current study was to make an unbiased assessment of which cerebral areas are affected in first-ever acute ischemic stroke patients identified as having language and speech impairments according to the National Institute of Health Stroke Scale (NIHSS).<br/><br>
Methods. Data from thirty-four patients with language and speech impairments, with a score of 1-3 on item 9 on the NIHSS, following ischemic stroke was collected from the Lund Stroke Register. MRI images acquired up to 20 days after stroke onset were used to create an overlap lesion image using MRIcron software.<br/><br>
Results. The classical language areas, Wernicke’s and Broca’s area, were affected in less than one fourth of the patients. The most frequently affected region was a subcortical region - the left caudate nucleus and the adjacent corona radiata.<br/><br>
Conclusions. These findings contribute to the growing body of evidence that the basal ganglia have a crucial role in the control over language and speech processing.}},
author = {{Grönholm, Erik and Roll, Mikael and Horne, Merle and Sundgren, Pia and Lindgren, Arne}},
issn = {{1351-5101}},
keywords = {{caudate nucleus; stroke; speech; language; MRI; basal ganglia}},
language = {{eng}},
number = {{1}},
pages = {{148--153}},
publisher = {{Wiley-Blackwell}},
series = {{European Journal of Neurology}},
title = {{Predominance of caudate nucleus lesions in acute ischemic stroke patients with impairments in language and speech}},
url = {{https://lup.lub.lu.se/search/files/8178661/8626801.pdf}},
doi = {{10.1111/ene.12822}},
volume = {{23}},
year = {{2016}},
}