Weight change in middle adulthood and breast cancer risk in the EPIC-PANACEA study
(2014) In International Journal of Cancer 135(12). p.2887-2899- Abstract
- Long-term weight gain (i.e., weight gain since age 20) has been related to higher risk of postmenopausal breast cancer, but a lower risk of premenopausal breast cancer. The effect of weight change in middle adulthood is unclear. We investigated the association between weight change in middle adulthood (i.e., women aged 40-50 years) and the risk of breast cancer before and after the age of 50. We included female participants of the European Prospective Investigation into Cancer and Nutrition cohort, with information on anthropometric measures at recruitment and after a median follow-up of 4.3 years. Annual weight change was categorized using quintiles taking quintile 2 and 3 as the reference category (-0.44 to 0.36 kg/year). Multivariable... (More)
- Long-term weight gain (i.e., weight gain since age 20) has been related to higher risk of postmenopausal breast cancer, but a lower risk of premenopausal breast cancer. The effect of weight change in middle adulthood is unclear. We investigated the association between weight change in middle adulthood (i.e., women aged 40-50 years) and the risk of breast cancer before and after the age of 50. We included female participants of the European Prospective Investigation into Cancer and Nutrition cohort, with information on anthropometric measures at recruitment and after a median follow-up of 4.3 years. Annual weight change was categorized using quintiles taking quintile 2 and 3 as the reference category (-0.44 to 0.36 kg/year). Multivariable Cox proportional hazards regression analysis was used to examine the association. 205,723 women were included and 4,663 incident breast cancer cases were diagnosed during a median follow-up of 7.5 years (from second weight assessment onward). High weight gain (Q5: 0.83-4.98 kg/year) was related to a slightly, but significantly higher breast cancer risk (HRQ5_versus_Q2/3: 1.09, 95% CI: 1.01-1.18). The association was more pronounced for breast cancer diagnosed before or at age 50 (HRQ5_versus_Q2/3: 1.37, 95% CI: 1.02-1.85). Weight loss was not associated with breast cancer risk. There was no evidence for heterogeneity by hormone receptor status. In conclusion, high weight gain in middle adulthood increases the risk of breast cancer. The association seems to be more pronounced for breast cancer diagnosed before or at age 50. Our results illustrate the importance of avoiding weight gain in middle adulthood. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4783941
- author
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- breast cancer, adult weight gain, menopausal status, estrogen receptor, progesterone receptor
- in
- International Journal of Cancer
- volume
- 135
- issue
- 12
- pages
- 2887 - 2899
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000343055600015
- scopus:84908873953
- pmid:24771551
- ISSN
- 0020-7136
- DOI
- 10.1002/ijc.28926
- language
- English
- LU publication?
- yes
- id
- 98732c14-f299-4176-b60a-dd8eea283353 (old id 4783941)
- date added to LUP
- 2016-04-01 10:57:37
- date last changed
- 2022-04-28 03:14:09
@article{98732c14-f299-4176-b60a-dd8eea283353,
abstract = {{Long-term weight gain (i.e., weight gain since age 20) has been related to higher risk of postmenopausal breast cancer, but a lower risk of premenopausal breast cancer. The effect of weight change in middle adulthood is unclear. We investigated the association between weight change in middle adulthood (i.e., women aged 40-50 years) and the risk of breast cancer before and after the age of 50. We included female participants of the European Prospective Investigation into Cancer and Nutrition cohort, with information on anthropometric measures at recruitment and after a median follow-up of 4.3 years. Annual weight change was categorized using quintiles taking quintile 2 and 3 as the reference category (-0.44 to 0.36 kg/year). Multivariable Cox proportional hazards regression analysis was used to examine the association. 205,723 women were included and 4,663 incident breast cancer cases were diagnosed during a median follow-up of 7.5 years (from second weight assessment onward). High weight gain (Q5: 0.83-4.98 kg/year) was related to a slightly, but significantly higher breast cancer risk (HRQ5_versus_Q2/3: 1.09, 95% CI: 1.01-1.18). The association was more pronounced for breast cancer diagnosed before or at age 50 (HRQ5_versus_Q2/3: 1.37, 95% CI: 1.02-1.85). Weight loss was not associated with breast cancer risk. There was no evidence for heterogeneity by hormone receptor status. In conclusion, high weight gain in middle adulthood increases the risk of breast cancer. The association seems to be more pronounced for breast cancer diagnosed before or at age 50. Our results illustrate the importance of avoiding weight gain in middle adulthood.}},
author = {{Emaus, Marleen J. and van Gils, Carla H. and Bakker, Marije F. and Bisschop, Charlotte N. Steins and Monninkhof, Evelyn M. and Bueno-de-Mesquita, H. B(as) and Travier, Noemie and Berentzen, Tina Landsvig and Overvad, Kim and Tjonneland, Anne and Romieu, Isabelle and Rinaldi, Sabina and Chajes, Veronique and Gunter, Marc J. and Clavel-Chapelon, Francoise and Fagherazzi, Guy and Mesrine, Sylvie and Chang-Claude, Jenny and Kaaks, Rudolf and Boeing, Heiner and Aleksandrova, Krasimira and Trichopoulou, Antonia and Naska, Androniki and Orfanos, Philippos and Palli, Domenico and Agnoli, Claudia and Tumino, Rosario and Vineis, Paolo and Mattiello, Amalia and Braaten, Tonje and Borch, Kristin Benjaminsen and Lund, Eiliv and Menendez, Virginia and Sanchez, Maria-Jose and Navarro, Carmen and Barricarte, Aurelio and Amiano, Pilar and Sund, Malin and Andersson, Anne and Borgquist, Signe and Olsson, Åsa and Khaw, Kay-Tee and Wareham, Nick and Travis, Ruth C. and Riboli, Elio and Peeters, Petra H. M. and May, Anne M.}},
issn = {{0020-7136}},
keywords = {{breast cancer; adult weight gain; menopausal status; estrogen receptor; progesterone receptor}},
language = {{eng}},
number = {{12}},
pages = {{2887--2899}},
publisher = {{John Wiley & Sons Inc.}},
series = {{International Journal of Cancer}},
title = {{Weight change in middle adulthood and breast cancer risk in the EPIC-PANACEA study}},
url = {{http://dx.doi.org/10.1002/ijc.28926}},
doi = {{10.1002/ijc.28926}},
volume = {{135}},
year = {{2014}},
}