Are Perinatal Events Risk Factors for Childhood Thyroid Autoimmunity?
Jonsdottir, Berglind LU ; Lundgren, Markus LU ; Wallengren, Sara LU ; Lernmark, Åke LU
; Jönsson, Ida
LU
and Elding Larsson, Helena
LU
(2017)
In European Thyroid Journal
6(6).
p.298-306
- Abstract
Background: Environmental and genetic factors possibly trigger thyroid autoimmunity. Studies on perinatal risk factors for childhood thyroid autoimmunity are sparse.
Objectives: The aim was to investigate if perinatal factors, family history of autoimmune diseases, and HLA-DQ genotypes contribute to thyroid autoimmunity in the Diabetes Prediction in Skåne (DiPiS) study.
Methods: Samples from 1,874 ten-year-old children were analyzed for autoantibodies to thyroid peroxidase (TPOAb), thyroglobulin (TGAb), and HLA-DQ genotypes. Information on perinatal events and family history of autoimmunity was gathered prospectively in questionnaires.
Results: Thyroid autoimmunity was found in 6.9% of the children (TPOAb 4.4%, TGAb... (More)
Background: Environmental and genetic factors possibly trigger thyroid autoimmunity. Studies on perinatal risk factors for childhood thyroid autoimmunity are sparse.
Objectives: The aim was to investigate if perinatal factors, family history of autoimmune diseases, and HLA-DQ genotypes contribute to thyroid autoimmunity in the Diabetes Prediction in Skåne (DiPiS) study.
Methods: Samples from 1,874 ten-year-old children were analyzed for autoantibodies to thyroid peroxidase (TPOAb), thyroglobulin (TGAb), and HLA-DQ genotypes. Information on perinatal events and family history of autoimmunity was gathered prospectively in questionnaires.
Results: Thyroid autoimmunity was found in 6.9% of the children (TPOAb 4.4%, TGAb 5.8%, both autoantibodies 3.3%) and was overrepresented in girls. Prematurity was positively related to TGAb (OR: 2.4, p = 0.003, p
c
= 0.021). Autoimmune diseases in the family increased the risk of thyroid autoimmunity: TPOAb (OR: 2.2, p = 0.012), any autoantibody (OR: 1.7, p = 0.04), and both autoantibodies (OR: 2.2, p = 0.024). A first-degree relative (FDR) with thyroid disease increased the risk for TPOAb (OR: 2.4, p = 0.03) and both autoantibodies (OR: 2.6, p = 0.03), a FDR or sibling with celiac disease increased the risk for both autoantibodies (OR: 3.7, p = 0.03, and OR: 4.8, p = 0.003), a FDR or sibling with diabetes increased the risk for thyroid autoantibody (OR: 3.0, p = 0.01, and OR: 5.4, p = 0.032), and a father with rheumatic disease increased the risk for TPOAb (OR: 15.2, p = 0.017), TGAb (OR: 11.3, p = 0.029), any autoantibody (OR: 9.6, p = 0.038), and both autoantibodies (OR: 20, p = 0.01).Conclusions: Thyroid autoimmunity was found in 6.9% of the 10-year-old children who were being followed for their risk of type 1 diabetes. No relation to perinatal factors was found, with the exception of a possible association between prematurity and TGAb. Family history of autoimmune diseases increased the risk of thyroid autoimmunity.
(Less)
- author
- Jonsdottir, Berglind
LU
; Lundgren, Markus
LU
; Wallengren, Sara
LU
; Lernmark, Åke
LU
; Jönsson, Ida
LU
and Elding Larsson, Helena
LU
- author collaboration
- organization
- publishing date
- 2017-11
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Thyroid Journal
- volume
- 6
- issue
- 6
- pages
- 298 - 306
- publisher
- Karger
- external identifiers
-
- pmid:29234623
- ISSN
- 2235-0640
- DOI
- 10.1159/000479964
- language
- English
- LU publication?
- yes
- id
- 50607be1-1d5d-4dc4-80cb-44fc3d4e587e
- date added to LUP
- 2019-06-25 13:25:52
- date last changed
- 2019-07-04 15:22:13
@article{50607be1-1d5d-4dc4-80cb-44fc3d4e587e,
abstract = {{<p>Background: Environmental and genetic factors possibly trigger thyroid autoimmunity. Studies on perinatal risk factors for childhood thyroid autoimmunity are sparse.</p><p>Objectives: The aim was to investigate if perinatal factors, family history of autoimmune diseases, and HLA-DQ genotypes contribute to thyroid autoimmunity in the Diabetes Prediction in Skåne (DiPiS) study.</p><p>Methods: Samples from 1,874 ten-year-old children were analyzed for autoantibodies to thyroid peroxidase (TPOAb), thyroglobulin (TGAb), and HLA-DQ genotypes. Information on perinatal events and family history of autoimmunity was gathered prospectively in questionnaires.</p><p>Results: Thyroid autoimmunity was found in 6.9% of the children (TPOAb 4.4%, TGAb 5.8%, both autoantibodies 3.3%) and was overrepresented in girls. Prematurity was positively related to TGAb (OR: 2.4, p = 0.003, p<br>
c<br>
= 0.021). Autoimmune diseases in the family increased the risk of thyroid autoimmunity: TPOAb (OR: 2.2, p = 0.012), any autoantibody (OR: 1.7, p = 0.04), and both autoantibodies (OR: 2.2, p = 0.024). A first-degree relative (FDR) with thyroid disease increased the risk for TPOAb (OR: 2.4, p = 0.03) and both autoantibodies (OR: 2.6, p = 0.03), a FDR or sibling with celiac disease increased the risk for both autoantibodies (OR: 3.7, p = 0.03, and OR: 4.8, p = 0.003), a FDR or sibling with diabetes increased the risk for thyroid autoantibody (OR: 3.0, p = 0.01, and OR: 5.4, p = 0.032), and a father with rheumatic disease increased the risk for TPOAb (OR: 15.2, p = 0.017), TGAb (OR: 11.3, p = 0.029), any autoantibody (OR: 9.6, p = 0.038), and both autoantibodies (OR: 20, p = 0.01).</p><p>Conclusions: Thyroid autoimmunity was found in 6.9% of the 10-year-old children who were being followed for their risk of type 1 diabetes. No relation to perinatal factors was found, with the exception of a possible association between prematurity and TGAb. Family history of autoimmune diseases increased the risk of thyroid autoimmunity.</p>}},
author = {{Jonsdottir, Berglind and Lundgren, Markus and Wallengren, Sara and Lernmark, Åke and Jönsson, Ida and Elding Larsson, Helena}},
issn = {{2235-0640}},
language = {{eng}},
number = {{6}},
pages = {{298--306}},
publisher = {{Karger}},
series = {{European Thyroid Journal}},
title = {{Are Perinatal Events Risk Factors for Childhood Thyroid Autoimmunity?}},
url = {{http://dx.doi.org/10.1159/000479964}},
doi = {{10.1159/000479964}},
volume = {{6}},
year = {{2017}},
}