Hypoxia down-regulates expression of secretory leukocyte protease inhibitor in bronchial epithelial cells via TGF-β1.
Påhlman, Lisa LU ; Jögi, Annika LU ; Gram, Magnus LU
; Mori, Michiko
LU
and Egesten, Arne
LU
(2015)
In BMC Pulmonary Medicine
15(1).
- Abstract
- Secretory leukocyte protease inhibitor (SLPI) is a protein with anti-protease and antimicrobial properties that is constitutively secreted from the airway epithelium. The importance of maintaining a balance between proteases and anti-proteases, and robust innate defence mechanisms in the airways, is exemplified by inflammatory lung conditions such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Both conditions present with a high protease burden in the airways which leads to tissue destruction. These patients also have an impaired innate immune system in the lungs with bacterial colonization and frequent airway infections. Moreover, both diseases are associated with airway hypoxia due to inflammation and mucus... (More)
- Secretory leukocyte protease inhibitor (SLPI) is a protein with anti-protease and antimicrobial properties that is constitutively secreted from the airway epithelium. The importance of maintaining a balance between proteases and anti-proteases, and robust innate defence mechanisms in the airways, is exemplified by inflammatory lung conditions such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Both conditions present with a high protease burden in the airways which leads to tissue destruction. These patients also have an impaired innate immune system in the lungs with bacterial colonization and frequent airway infections. Moreover, both diseases are associated with airway hypoxia due to inflammation and mucus plugs. The aim of the present study was to investigate the role of hypoxia on SLPI production from the airway epithelium. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5258447
- author
- Påhlman, Lisa
LU
; Jögi, Annika
LU
; Gram, Magnus
LU
; Mori, Michiko
LU
and Egesten, Arne
LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BMC Pulmonary Medicine
- volume
- 15
- issue
- 1
- article number
- 19
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:25778525
- wos:000351983900001
- scopus:84925883006
- pmid:25851169
- ISSN
- 1471-2466
- DOI
- 10.1186/s12890-015-0016-0
- language
- English
- LU publication?
- yes
- id
- db98ba7b-1bc1-46e5-bdab-5f0bbca4bb99 (old id 5258447)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25778525?dopt=Abstract
- date added to LUP
- 2016-04-01 13:44:41
- date last changed
- 2022-03-29 17:11:16
@article{db98ba7b-1bc1-46e5-bdab-5f0bbca4bb99,
abstract = {{Secretory leukocyte protease inhibitor (SLPI) is a protein with anti-protease and antimicrobial properties that is constitutively secreted from the airway epithelium. The importance of maintaining a balance between proteases and anti-proteases, and robust innate defence mechanisms in the airways, is exemplified by inflammatory lung conditions such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Both conditions present with a high protease burden in the airways which leads to tissue destruction. These patients also have an impaired innate immune system in the lungs with bacterial colonization and frequent airway infections. Moreover, both diseases are associated with airway hypoxia due to inflammation and mucus plugs. The aim of the present study was to investigate the role of hypoxia on SLPI production from the airway epithelium.}},
author = {{Påhlman, Lisa and Jögi, Annika and Gram, Magnus and Mori, Michiko and Egesten, Arne}},
issn = {{1471-2466}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Pulmonary Medicine}},
title = {{Hypoxia down-regulates expression of secretory leukocyte protease inhibitor in bronchial epithelial cells via TGF-β1.}},
url = {{https://lup.lub.lu.se/search/files/3566042/8260271}},
doi = {{10.1186/s12890-015-0016-0}},
volume = {{15}},
year = {{2015}},
}