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Medial temporal lobe atrophy patterns in early-versus late-onset amnestic Alzheimer's disease

Wuestefeld, Anika LU orcid ; Pichet Binette, Alexa LU ; van Westen, Danielle LU orcid ; Strandberg, Olof LU ; Stomrud, Erik LU orcid ; Mattsson-Carlgren, Niklas LU orcid ; Janelidze, Shorena LU ; Smith, Ruben LU ; Palmqvist, Sebastian LU orcid and Baumeister, Hannah LU , et al. (2024) In Alzheimer's Research & Therapy 16(1).
Abstract

BACKGROUND: The medial temporal lobe (MTL) is hypothesized to be relatively spared in early-onset Alzheimer's disease (EOAD). Yet, detailed examination of MTL subfields and drivers of atrophy in amnestic EOAD is lacking.

METHODS: BioFINDER-2 participants with memory impairment, abnormal amyloid-β and tau-PET were included. Forty-one amnestic EOAD individuals ≤65 years and, as comparison, late-onset AD (aLOAD, ≥70 years, n = 154) and amyloid-β-negative cognitively unimpaired controls were included. MTL subregions and biomarkers of (co-)pathologies were measured.

RESULTS: AD groups showed smaller MTL subregions compared to controls. Atrophy patterns were similar across AD groups: aLOAD showed thinner entorhinal cortices than... (More)

BACKGROUND: The medial temporal lobe (MTL) is hypothesized to be relatively spared in early-onset Alzheimer's disease (EOAD). Yet, detailed examination of MTL subfields and drivers of atrophy in amnestic EOAD is lacking.

METHODS: BioFINDER-2 participants with memory impairment, abnormal amyloid-β and tau-PET were included. Forty-one amnestic EOAD individuals ≤65 years and, as comparison, late-onset AD (aLOAD, ≥70 years, n = 154) and amyloid-β-negative cognitively unimpaired controls were included. MTL subregions and biomarkers of (co-)pathologies were measured.

RESULTS: AD groups showed smaller MTL subregions compared to controls. Atrophy patterns were similar across AD groups: aLOAD showed thinner entorhinal cortices than aEOAD; aEOAD showed thinner parietal regions than aLOAD. aEOAD showed lower white matter hyperintensities than aLOAD. No differences in MTL tau-PET or transactive response DNA binding protein 43-proxy positivity were found.

CONCLUSIONS: We found evidence for MTL atrophy in amnestic EOAD and overall similar levels to aLOAD of MTL tau pathology and co-pathologies.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Humans, Alzheimer Disease/pathology, Atrophy/pathology, Male, Female, Aged, Temporal Lobe/pathology, Middle Aged, Positron-Emission Tomography, Magnetic Resonance Imaging, tau Proteins/metabolism, Age of Onset, Amyloid beta-Peptides/metabolism, Amnesia/pathology, Aged, 80 and over, tau-PET imaging, Amyloid-beta, MRI, Medial temporal lobe subregions, aging, in vivo, Amnestic AD, Early-onset, late-onset, Amygdala segmentation protocol, TPD-43
in
Alzheimer's Research & Therapy
volume
16
issue
1
article number
204
pages
12 pages
publisher
BioMed Central (BMC)
external identifiers
  • pmid:39285454
ISSN
1758-9193
DOI
10.1186/s13195-024-01571-z
language
English
LU publication?
yes
additional info
© 2024. The Author(s).
id
53fb429f-2f7b-4e69-9cdd-6ea9c3c0e129
date added to LUP
2024-09-20 09:12:24
date last changed
2024-09-20 10:35:09
@article{53fb429f-2f7b-4e69-9cdd-6ea9c3c0e129,
  abstract     = {{<p>BACKGROUND: The medial temporal lobe (MTL) is hypothesized to be relatively spared in early-onset Alzheimer's disease (EOAD). Yet, detailed examination of MTL subfields and drivers of atrophy in amnestic EOAD is lacking.</p><p>METHODS: BioFINDER-2 participants with memory impairment, abnormal amyloid-β and tau-PET were included. Forty-one amnestic EOAD individuals ≤65 years and, as comparison, late-onset AD (aLOAD, ≥70 years, n = 154) and amyloid-β-negative cognitively unimpaired controls were included. MTL subregions and biomarkers of (co-)pathologies were measured.</p><p>RESULTS: AD groups showed smaller MTL subregions compared to controls. Atrophy patterns were similar across AD groups: aLOAD showed thinner entorhinal cortices than aEOAD; aEOAD showed thinner parietal regions than aLOAD. aEOAD showed lower white matter hyperintensities than aLOAD. No differences in MTL tau-PET or transactive response DNA binding protein 43-proxy positivity were found.</p><p>CONCLUSIONS: We found evidence for MTL atrophy in amnestic EOAD and overall similar levels to aLOAD of MTL tau pathology and co-pathologies.</p>}},
  author       = {{Wuestefeld, Anika and Pichet Binette, Alexa and van Westen, Danielle and Strandberg, Olof and Stomrud, Erik and Mattsson-Carlgren, Niklas and Janelidze, Shorena and Smith, Ruben and Palmqvist, Sebastian and Baumeister, Hannah and Berron, David and Yushkevich, Paul A and Hansson, Oskar and Spotorno, Nicola and Wisse, Laura E M}},
  issn         = {{1758-9193}},
  keywords     = {{Humans; Alzheimer Disease/pathology; Atrophy/pathology; Male; Female; Aged; Temporal Lobe/pathology; Middle Aged; Positron-Emission Tomography; Magnetic Resonance Imaging; tau Proteins/metabolism; Age of Onset; Amyloid beta-Peptides/metabolism; Amnesia/pathology; Aged, 80 and over; tau-PET imaging; Amyloid-beta; MRI; Medial temporal lobe subregions; aging; in vivo; Amnestic AD; Early-onset; late-onset; Amygdala segmentation protocol; TPD-43}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Alzheimer's Research & Therapy}},
  title        = {{Medial temporal lobe atrophy patterns in early-versus late-onset amnestic Alzheimer's disease}},
  url          = {{http://dx.doi.org/10.1186/s13195-024-01571-z}},
  doi          = {{10.1186/s13195-024-01571-z}},
  volume       = {{16}},
  year         = {{2024}},
}