Age-stratified comparison of prognosis in cardiac resynchronization therapy with or without prophylactic defibrillator for non-ischemic cardiomyopathy – a nationwide cohort study
(2023) In Europace 25(7).- Abstract
- Background and aims
Prior studies have suggested that the benefit from primary preventive defibrillator treatment for patients with non-ischemic cardiomyopathy primarily, treated with cardiac resynchronization therapy, may be age-dependent. We aimed to compare age-stratified mortality rates and mode of death in patients with non-ischemic cardiomyopathy who are treated with either primary preventive Cardiac Resynchronization Therapy-defibrillator (CRT-D) or CRT-pacemaker (CRT-P).
Methods
All patients with non-ischemic cardiomyopathy and CRT-P or primary preventive CRT-D who were implanted in Sweden during the period 2005-2020 were included. Propensity scoring was used to create a matched cohort. Primary outcome was... (More) - Background and aims
Prior studies have suggested that the benefit from primary preventive defibrillator treatment for patients with non-ischemic cardiomyopathy primarily, treated with cardiac resynchronization therapy, may be age-dependent. We aimed to compare age-stratified mortality rates and mode of death in patients with non-ischemic cardiomyopathy who are treated with either primary preventive Cardiac Resynchronization Therapy-defibrillator (CRT-D) or CRT-pacemaker (CRT-P).
Methods
All patients with non-ischemic cardiomyopathy and CRT-P or primary preventive CRT-D who were implanted in Sweden during the period 2005-2020 were included. Propensity scoring was used to create a matched cohort. Primary outcome was all-cause mortality within five years.
Results
4027 patients were included, 2334 with CRT-P and 1693 with CRT-D. Crude 5-year mortality was 635 (27%) vs. 246 (15%), p
Conclusion
In this nationwide registry-based study, patients with CRT-D have better five-year survival compared to patients with CRT-P. The interaction between age and mortality reduction not consistent, but patients with CRT-D aged (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/55a5a53c-b0e7-4eeb-a293-0f5dfdc76e19
- author
- Farouq, Maiwand LU ; Rorsman, Cecilia LU ; Marinko, Sofia LU ; Mörtsell, David LU ; Chaudhry, Uzma LU ; Wang, Lingwei LU ; Platonov, Pyotr LU and Borgquist, Rasmus LU
- organization
- publishing date
- 2023-07-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Europace
- volume
- 25
- issue
- 7
- article number
- euad187
- publisher
- Oxford University Press
- external identifiers
-
- pmid:37392462
- scopus:85192148651
- ISSN
- 1532-2092
- DOI
- 10.1093/europace/euad187
- language
- English
- LU publication?
- yes
- id
- 55a5a53c-b0e7-4eeb-a293-0f5dfdc76e19
- date added to LUP
- 2023-06-06 17:03:44
- date last changed
- 2024-05-15 11:49:40
@article{55a5a53c-b0e7-4eeb-a293-0f5dfdc76e19, abstract = {{Background and aims<br/>Prior studies have suggested that the benefit from primary preventive defibrillator treatment for patients with non-ischemic cardiomyopathy primarily, treated with cardiac resynchronization therapy, may be age-dependent. We aimed to compare age-stratified mortality rates and mode of death in patients with non-ischemic cardiomyopathy who are treated with either primary preventive Cardiac Resynchronization Therapy-defibrillator (CRT-D) or CRT-pacemaker (CRT-P).<br/><br/>Methods<br/>All patients with non-ischemic cardiomyopathy and CRT-P or primary preventive CRT-D who were implanted in Sweden during the period 2005-2020 were included. Propensity scoring was used to create a matched cohort. Primary outcome was all-cause mortality within five years.<br/><br/>Results<br/>4027 patients were included, 2334 with CRT-P and 1693 with CRT-D. Crude 5-year mortality was 635 (27%) vs. 246 (15%), p <br/>Conclusion<br/>In this nationwide registry-based study, patients with CRT-D have better five-year survival compared to patients with CRT-P. The interaction between age and mortality reduction not consistent, but patients with CRT-D aged}}, author = {{Farouq, Maiwand and Rorsman, Cecilia and Marinko, Sofia and Mörtsell, David and Chaudhry, Uzma and Wang, Lingwei and Platonov, Pyotr and Borgquist, Rasmus}}, issn = {{1532-2092}}, language = {{eng}}, month = {{07}}, number = {{7}}, publisher = {{Oxford University Press}}, series = {{Europace}}, title = {{Age-stratified comparison of prognosis in cardiac resynchronization therapy with or without prophylactic defibrillator for non-ischemic cardiomyopathy – a nationwide cohort study}}, url = {{http://dx.doi.org/10.1093/europace/euad187}}, doi = {{10.1093/europace/euad187}}, volume = {{25}}, year = {{2023}}, }