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Age-stratified comparison of prognosis in cardiac resynchronization therapy with or without prophylactic defibrillator for non-ischemic cardiomyopathy – a nationwide cohort study

Farouq, Maiwand LU ; Rorsman, Cecilia LU ; Marinko, Sofia LU ; Mörtsell, David LU orcid ; Chaudhry, Uzma LU ; Wang, Lingwei LU orcid ; Platonov, Pyotr LU and Borgquist, Rasmus LU orcid (2023) In Europace 25(7).
Abstract
Background and aims
Prior studies have suggested that the benefit from primary preventive defibrillator treatment for patients with non-ischemic cardiomyopathy primarily, treated with cardiac resynchronization therapy, may be age-dependent. We aimed to compare age-stratified mortality rates and mode of death in patients with non-ischemic cardiomyopathy who are treated with either primary preventive Cardiac Resynchronization Therapy-defibrillator (CRT-D) or CRT-pacemaker (CRT-P).

Methods
All patients with non-ischemic cardiomyopathy and CRT-P or primary preventive CRT-D who were implanted in Sweden during the period 2005-2020 were included. Propensity scoring was used to create a matched cohort. Primary outcome was... (More)
Background and aims
Prior studies have suggested that the benefit from primary preventive defibrillator treatment for patients with non-ischemic cardiomyopathy primarily, treated with cardiac resynchronization therapy, may be age-dependent. We aimed to compare age-stratified mortality rates and mode of death in patients with non-ischemic cardiomyopathy who are treated with either primary preventive Cardiac Resynchronization Therapy-defibrillator (CRT-D) or CRT-pacemaker (CRT-P).

Methods
All patients with non-ischemic cardiomyopathy and CRT-P or primary preventive CRT-D who were implanted in Sweden during the period 2005-2020 were included. Propensity scoring was used to create a matched cohort. Primary outcome was all-cause mortality within five years.

Results
4027 patients were included, 2334 with CRT-P and 1693 with CRT-D. Crude 5-year mortality was 635 (27%) vs. 246 (15%), p 
Conclusion
In this nationwide registry-based study, patients with CRT-D have better five-year survival compared to patients with CRT-P. The interaction between age and mortality reduction not consistent, but patients with CRT-D aged (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Europace
volume
25
issue
7
article number
euad187
publisher
Oxford University Press
external identifiers
  • pmid:37392462
  • scopus:85192148651
ISSN
1532-2092
DOI
10.1093/europace/euad187
language
English
LU publication?
yes
id
55a5a53c-b0e7-4eeb-a293-0f5dfdc76e19
date added to LUP
2023-06-06 17:03:44
date last changed
2024-05-15 11:49:40
@article{55a5a53c-b0e7-4eeb-a293-0f5dfdc76e19,
  abstract     = {{Background and aims<br/>Prior studies have suggested that the benefit from primary preventive defibrillator treatment for patients with non-ischemic cardiomyopathy primarily, treated with cardiac resynchronization therapy, may be age-dependent. We aimed to compare age-stratified mortality rates and mode of death in patients with non-ischemic cardiomyopathy who are treated with either primary preventive Cardiac Resynchronization Therapy-defibrillator (CRT-D) or CRT-pacemaker (CRT-P).<br/><br/>Methods<br/>All patients with non-ischemic cardiomyopathy and CRT-P or primary preventive CRT-D who were implanted in Sweden during the period 2005-2020 were included. Propensity scoring was used to create a matched cohort. Primary outcome was all-cause mortality within five years.<br/><br/>Results<br/>4027 patients were included, 2334 with CRT-P and 1693 with CRT-D. Crude 5-year mortality was 635 (27%) vs. 246 (15%), p <br/>Conclusion<br/>In this nationwide registry-based study, patients with CRT-D have better five-year survival compared to patients with CRT-P. The interaction between age and mortality reduction not consistent, but patients with CRT-D aged}},
  author       = {{Farouq, Maiwand and Rorsman, Cecilia and Marinko, Sofia and Mörtsell, David and Chaudhry, Uzma and Wang, Lingwei and Platonov, Pyotr and Borgquist, Rasmus}},
  issn         = {{1532-2092}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{7}},
  publisher    = {{Oxford University Press}},
  series       = {{Europace}},
  title        = {{Age-stratified comparison of prognosis in cardiac resynchronization therapy with or without prophylactic defibrillator for non-ischemic cardiomyopathy – a nationwide cohort study}},
  url          = {{http://dx.doi.org/10.1093/europace/euad187}},
  doi          = {{10.1093/europace/euad187}},
  volume       = {{25}},
  year         = {{2023}},
}