Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

The chromosome 9p21 variant interacts with vegetable and wine intake to influence the risk of cardiovascular disease : a population based cohort study

Hindy, George LU ; Ericson, Ulrika LU ; Hamrefors, Viktor LU orcid ; Drake, Isabel LU ; Wirfält, Elisabet LU ; Melander, Olle LU orcid and Orho-Melander, Marju LU (2014) In BMC Medical Genetics 15.
Abstract

BACKGROUND: Chromosome 9p21 variants are associated with cardiovascular disease (CVD) but not with any of its known risk markers. However, recent studies have suggested that the risk associated with 9p21 variation is modified by a prudent dietary pattern and smoking. We tested if the increased risk of CVD by the 9p21 single nucleotide polymorphism rs4977574 is modified by intakes of vegetables, fruits, alcohol, or wine, and if rs4977574 interacts with environmental factors on known CVD risk markers.

METHODS: Multivariable Cox regression analyses were performed in 23,949 individuals from the population-based prospective Malmö Diet and Cancer Study (MDCS), of whom 3,164 developed CVD during 15 years of follow-up. The rs4977574... (More)

BACKGROUND: Chromosome 9p21 variants are associated with cardiovascular disease (CVD) but not with any of its known risk markers. However, recent studies have suggested that the risk associated with 9p21 variation is modified by a prudent dietary pattern and smoking. We tested if the increased risk of CVD by the 9p21 single nucleotide polymorphism rs4977574 is modified by intakes of vegetables, fruits, alcohol, or wine, and if rs4977574 interacts with environmental factors on known CVD risk markers.

METHODS: Multivariable Cox regression analyses were performed in 23,949 individuals from the population-based prospective Malmö Diet and Cancer Study (MDCS), of whom 3,164 developed CVD during 15 years of follow-up. The rs4977574 variant (major allele: A; minor allele: G) was genotyped using TaqMan® Assay Design probes. Dietary data were collected at baseline using a modified diet history method. Cross-sectional analyses were performed in 4,828 MDCS participants with fasting blood levels of circulating risk factors measured at baseline.

RESULTS: Each rs4977574 G allele was associated with a 16% increased incidence of CVD (95% confidence interval (CI), 1.10-1.22). Higher vegetable intake (hazard ratio (HR), 0.95 [CI: 0.91-0.996]), wine intake (HR, 0.91 [CI: 0.86-0.96]), and total alcohol consumption (HR, 0.92 [CI: 0.86-0.98]) were associated with lower CVD incidence. The increased CVD incidence by the G allele was restricted to individuals with medium or high vegetable intake (Pinteraction = 0.043), and to non- and low consumers of wine (Pinteraction = 0.029). Although rs4977574 did not associate with any known risk markers, stratification by vegetable intake and smoking suggested an interaction with rs4977574 on glycated hemoglobin and high-density lipoprotein cholesterol (Pinteraction = 0.015 and 0.049, respectively).

CONCLUSIONS: Our results indicate that rs4977574 interacts with vegetable and wine intake to affect the incidence of CVD, and suggest that an interaction may exist between environmental risk factors and rs4977574 on known risk markers of CVD.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aged, Alleles, Body Mass Index, Cardiovascular Diseases, Cholesterol, HDL, Cholesterol, LDL, Chromosomes, Human, Pair 9, Cross-Sectional Studies, Diet, Energy Intake, Female, Follow-Up Studies, Fruit, Genotyping Techniques, Hemoglobin A, Glycosylated, Humans, Incidence, Male, Middle Aged, Multivariate Analysis, Nutrition Assessment, Polymorphism, Single Nucleotide, Proportional Hazards Models, Prospective Studies, Risk Factors, Triglycerides, Vegetables, Wine, Journal Article, Research Support, Non-U.S. Gov't
in
BMC Medical Genetics
volume
15
article number
1220
publisher
BioMed Central (BMC)
external identifiers
  • scopus:84923855111
  • pmid:25551366
ISSN
1471-2350
DOI
10.1186/s12881-014-0138-x
language
English
LU publication?
yes
id
560becaa-a905-4497-9ac7-0bf64c99735e
date added to LUP
2017-06-11 23:08:20
date last changed
2024-03-13 10:46:13
@article{560becaa-a905-4497-9ac7-0bf64c99735e,
  abstract     = {{<p>BACKGROUND: Chromosome 9p21 variants are associated with cardiovascular disease (CVD) but not with any of its known risk markers. However, recent studies have suggested that the risk associated with 9p21 variation is modified by a prudent dietary pattern and smoking. We tested if the increased risk of CVD by the 9p21 single nucleotide polymorphism rs4977574 is modified by intakes of vegetables, fruits, alcohol, or wine, and if rs4977574 interacts with environmental factors on known CVD risk markers.</p><p>METHODS: Multivariable Cox regression analyses were performed in 23,949 individuals from the population-based prospective Malmö Diet and Cancer Study (MDCS), of whom 3,164 developed CVD during 15 years of follow-up. The rs4977574 variant (major allele: A; minor allele: G) was genotyped using TaqMan® Assay Design probes. Dietary data were collected at baseline using a modified diet history method. Cross-sectional analyses were performed in 4,828 MDCS participants with fasting blood levels of circulating risk factors measured at baseline.</p><p>RESULTS: Each rs4977574 G allele was associated with a 16% increased incidence of CVD (95% confidence interval (CI), 1.10-1.22). Higher vegetable intake (hazard ratio (HR), 0.95 [CI: 0.91-0.996]), wine intake (HR, 0.91 [CI: 0.86-0.96]), and total alcohol consumption (HR, 0.92 [CI: 0.86-0.98]) were associated with lower CVD incidence. The increased CVD incidence by the G allele was restricted to individuals with medium or high vegetable intake (Pinteraction = 0.043), and to non- and low consumers of wine (Pinteraction = 0.029). Although rs4977574 did not associate with any known risk markers, stratification by vegetable intake and smoking suggested an interaction with rs4977574 on glycated hemoglobin and high-density lipoprotein cholesterol (Pinteraction = 0.015 and 0.049, respectively).</p><p>CONCLUSIONS: Our results indicate that rs4977574 interacts with vegetable and wine intake to affect the incidence of CVD, and suggest that an interaction may exist between environmental risk factors and rs4977574 on known risk markers of CVD.</p>}},
  author       = {{Hindy, George and Ericson, Ulrika and Hamrefors, Viktor and Drake, Isabel and Wirfält, Elisabet and Melander, Olle and Orho-Melander, Marju}},
  issn         = {{1471-2350}},
  keywords     = {{Aged; Alleles; Body Mass Index; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Chromosomes, Human, Pair 9; Cross-Sectional Studies; Diet; Energy Intake; Female; Follow-Up Studies; Fruit; Genotyping Techniques; Hemoglobin A, Glycosylated; Humans; Incidence; Male; Middle Aged; Multivariate Analysis; Nutrition Assessment; Polymorphism, Single Nucleotide; Proportional Hazards Models; Prospective Studies; Risk Factors; Triglycerides; Vegetables; Wine; Journal Article; Research Support, Non-U.S. Gov't}},
  language     = {{eng}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{BMC Medical Genetics}},
  title        = {{The chromosome 9p21 variant interacts with vegetable and wine intake to influence the risk of cardiovascular disease : a population based cohort study}},
  url          = {{http://dx.doi.org/10.1186/s12881-014-0138-x}},
  doi          = {{10.1186/s12881-014-0138-x}},
  volume       = {{15}},
  year         = {{2014}},
}