Obesity-associated Blunted Subcutaneous Adipose Tissue Blood Flow After Meal Improves After Bariatric Surgery
(2022) In Journal of Clinical Endocrinology and Metabolism 107(7). p.1930-1938- Abstract
Context: Glucose-dependent insulinotropic peptide (GIP) and meal ingestion increase subcutaneous adipose tissue (SAT) perfusion in healthy individuals. The effects of GIP and a meal on visceral adipose tissue (VAT) perfusion are unclear. Objective: Our aim was to investigate the effects of meal and GIP on VAT and SAT perfusion in obese individuals with type 2 diabetes mellitus (T2DM) before and after bariatric surgery. Methods: We recruited 10 obese individuals with T2DM scheduled for bariatric surgery and 10 control individuals. Participants were studied under 2 stimulations: meal ingestion and GIP infusion. SAT and VAT perfusion was measured using 15O-H2O positron emission tomography-magnetic resonance imaging at 3 time points:... (More)
Context: Glucose-dependent insulinotropic peptide (GIP) and meal ingestion increase subcutaneous adipose tissue (SAT) perfusion in healthy individuals. The effects of GIP and a meal on visceral adipose tissue (VAT) perfusion are unclear. Objective: Our aim was to investigate the effects of meal and GIP on VAT and SAT perfusion in obese individuals with type 2 diabetes mellitus (T2DM) before and after bariatric surgery. Methods: We recruited 10 obese individuals with T2DM scheduled for bariatric surgery and 10 control individuals. Participants were studied under 2 stimulations: meal ingestion and GIP infusion. SAT and VAT perfusion was measured using 15O-H2O positron emission tomography-magnetic resonance imaging at 3 time points: baseline, 20 minutes, and 50 minutes after the start of stimulation. Obese individuals were studied before and after bariatric surgery. Results: Before bariatric surgery the responses of SAT perfusion to meal (P = .04) and GIP-infusion (P = .002) were blunted in the obese participants compared to controls. VAT perfusion response did not differ between obese and control individuals after a meal or GIP infusion. After bariatric surgery SAT perfusion response to a meal was similar to that of controls. SAT perfusion response to GIP administration remained lower in the operated-on than control participants. There was no change in VAT perfusion response after bariatric surgery. Conclusion: The vasodilating effects of GIP and meal are blunted in SAT but not in VAT in obese individuals with T2DM. Bariatric surgery improves the effects of a meal on SAT perfusion, but not the effects of GIP. Postprandial increase in SAT perfusion after bariatric surgery seems to be regulated in a GIP-independent manner.
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- author
- Saari, Teemu ; Koffert, Jukka ; Honka, Henri ; Kauhanen, Saila ; U-Din, Mueez ; Wierup, Nils LU ; Lindqvist, Andreas LU ; Groop, Leif LU ; Virtanen, Kirsi A. and Nuutila, Pirjo
- organization
- publishing date
- 2022-07-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- adipose tissue, bariatric surgery, blood flow, glucose-dependent insulinotropic polypeptide, positron emission tomography, type 2 diabetes
- in
- Journal of Clinical Endocrinology and Metabolism
- volume
- 107
- issue
- 7
- pages
- 9 pages
- publisher
- Oxford University Press
- external identifiers
-
- scopus:85132454325
- pmid:35363252
- ISSN
- 0021-972X
- DOI
- 10.1210/clinem/dgac191
- language
- English
- LU publication?
- yes
- id
- 5f0e0a3c-0295-4645-b4c1-dd294d405096
- date added to LUP
- 2022-09-28 11:13:54
- date last changed
- 2025-06-14 05:53:40
@article{5f0e0a3c-0295-4645-b4c1-dd294d405096,
abstract = {{<p>Context: Glucose-dependent insulinotropic peptide (GIP) and meal ingestion increase subcutaneous adipose tissue (SAT) perfusion in healthy individuals. The effects of GIP and a meal on visceral adipose tissue (VAT) perfusion are unclear. Objective: Our aim was to investigate the effects of meal and GIP on VAT and SAT perfusion in obese individuals with type 2 diabetes mellitus (T2DM) before and after bariatric surgery. Methods: We recruited 10 obese individuals with T2DM scheduled for bariatric surgery and 10 control individuals. Participants were studied under 2 stimulations: meal ingestion and GIP infusion. SAT and VAT perfusion was measured using 15O-H2O positron emission tomography-magnetic resonance imaging at 3 time points: baseline, 20 minutes, and 50 minutes after the start of stimulation. Obese individuals were studied before and after bariatric surgery. Results: Before bariatric surgery the responses of SAT perfusion to meal (P = .04) and GIP-infusion (P = .002) were blunted in the obese participants compared to controls. VAT perfusion response did not differ between obese and control individuals after a meal or GIP infusion. After bariatric surgery SAT perfusion response to a meal was similar to that of controls. SAT perfusion response to GIP administration remained lower in the operated-on than control participants. There was no change in VAT perfusion response after bariatric surgery. Conclusion: The vasodilating effects of GIP and meal are blunted in SAT but not in VAT in obese individuals with T2DM. Bariatric surgery improves the effects of a meal on SAT perfusion, but not the effects of GIP. Postprandial increase in SAT perfusion after bariatric surgery seems to be regulated in a GIP-independent manner. </p>}},
author = {{Saari, Teemu and Koffert, Jukka and Honka, Henri and Kauhanen, Saila and U-Din, Mueez and Wierup, Nils and Lindqvist, Andreas and Groop, Leif and Virtanen, Kirsi A. and Nuutila, Pirjo}},
issn = {{0021-972X}},
keywords = {{adipose tissue; bariatric surgery; blood flow; glucose-dependent insulinotropic polypeptide; positron emission tomography; type 2 diabetes}},
language = {{eng}},
month = {{07}},
number = {{7}},
pages = {{1930--1938}},
publisher = {{Oxford University Press}},
series = {{Journal of Clinical Endocrinology and Metabolism}},
title = {{Obesity-associated Blunted Subcutaneous Adipose Tissue Blood Flow After Meal Improves After Bariatric Surgery}},
url = {{http://dx.doi.org/10.1210/clinem/dgac191}},
doi = {{10.1210/clinem/dgac191}},
volume = {{107}},
year = {{2022}},
}