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Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics

Strakosas, Xenofon LU ; Biesmans, Hanne ; Abrahamsson, Tobias ; Hellman, Karin LU ; Ejneby, Malin Silverå ; Donahue, Mary J ; Ekström, Peter LU ; Ek, Fredrik LU ; Savvakis, Marios and Hjort, Martin LU orcid , et al. (2023) In Science (New York, N.Y.) 379(6634). p.795-802
Abstract

Interfacing electronics with neural tissue is crucial for understanding complex biological functions, but conventional bioelectronics consist of rigid electrodes fundamentally incompatible with living systems. The difference between static solid-state electronics and dynamic biological matter makes seamless integration of the two challenging. To address this incompatibility, we developed a method to dynamically create soft substrate-free conducting materials within the biological environment. We demonstrate in vivo electrode formation in zebrafish and leech models, using endogenous metabolites to trigger enzymatic polymerization of organic precursors within an injectable gel, thereby forming conducting polymer gels with long-range... (More)

Interfacing electronics with neural tissue is crucial for understanding complex biological functions, but conventional bioelectronics consist of rigid electrodes fundamentally incompatible with living systems. The difference between static solid-state electronics and dynamic biological matter makes seamless integration of the two challenging. To address this incompatibility, we developed a method to dynamically create soft substrate-free conducting materials within the biological environment. We demonstrate in vivo electrode formation in zebrafish and leech models, using endogenous metabolites to trigger enzymatic polymerization of organic precursors within an injectable gel, thereby forming conducting polymer gels with long-range conductivity. This approach can be used to target specific biological substructures and is suitable for nerve stimulation, paving the way for fully integrated, in vivo-fabricated electronics within the nervous system.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Science (New York, N.Y.)
volume
379
issue
6634
pages
795 - 802
publisher
American Association for the Advancement of Science (AAAS)
external identifiers
  • pmid:36821679
  • scopus:85148681544
ISSN
1095-9203
DOI
10.1126/science.adc9998
language
English
LU publication?
yes
id
60978584-39dc-4030-a013-49a180fe2477
alternative location
https://www.science.org/doi/10.1126/science.adc9998?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
date added to LUP
2023-02-27 08:52:34
date last changed
2024-05-30 10:07:50
@article{60978584-39dc-4030-a013-49a180fe2477,
  abstract     = {{<p>Interfacing electronics with neural tissue is crucial for understanding complex biological functions, but conventional bioelectronics consist of rigid electrodes fundamentally incompatible with living systems. The difference between static solid-state electronics and dynamic biological matter makes seamless integration of the two challenging. To address this incompatibility, we developed a method to dynamically create soft substrate-free conducting materials within the biological environment. We demonstrate in vivo electrode formation in zebrafish and leech models, using endogenous metabolites to trigger enzymatic polymerization of organic precursors within an injectable gel, thereby forming conducting polymer gels with long-range conductivity. This approach can be used to target specific biological substructures and is suitable for nerve stimulation, paving the way for fully integrated, in vivo-fabricated electronics within the nervous system.</p>}},
  author       = {{Strakosas, Xenofon and Biesmans, Hanne and Abrahamsson, Tobias and Hellman, Karin and Ejneby, Malin Silverå and Donahue, Mary J and Ekström, Peter and Ek, Fredrik and Savvakis, Marios and Hjort, Martin and Bliman, David and Linares, Mathieu and Lindholm, Caroline and Stavrinidou, Eleni and Gerasimov, Jennifer Y and Simon, Daniel T and Olsson, Roger and Berggren, Magnus}},
  issn         = {{1095-9203}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{6634}},
  pages        = {{795--802}},
  publisher    = {{American Association for the Advancement of Science (AAAS)}},
  series       = {{Science (New York, N.Y.)}},
  title        = {{Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics}},
  url          = {{http://dx.doi.org/10.1126/science.adc9998}},
  doi          = {{10.1126/science.adc9998}},
  volume       = {{379}},
  year         = {{2023}},
}