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Pharmacokinetic study of a systemically administered novel liposomal Temoporfin formulation in an animal tumor model

Svensson, Jenny LU ; Johansson, Ann LU ; Bendsöe, Niels LU ; Grafe, Susanna ; Trebst, Tilmann ; Andersson-Engels, Stefan LU and Svanberg, Katarina LU (2007) Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI 6427. p.4270-4270
Abstract
Meso-tetra(hydroxyphenyl)chlorin (mTHPC) (international generic name Temoporfin) is a potent photosensitizer used for photodynamic therapy (PDT). In this study the pharmacokinetics of a systemically administered novel lipid formulation of Temoporfin in a murine tumor model has been investigated. Fluorescence spectroscopy measurements were performed at several time intervals following drug administration, yielding information on the Temoporfin concentration within excised internal organs as a function of time after injection. Both point-monitoring and imaging setups were used. The acquired fluorescence data were correlated to the concentration of Temoporfin obtained with High Performance Liquid Chromatography (HPLC). There was a significant... (More)
Meso-tetra(hydroxyphenyl)chlorin (mTHPC) (international generic name Temoporfin) is a potent photosensitizer used for photodynamic therapy (PDT). In this study the pharmacokinetics of a systemically administered novel lipid formulation of Temoporfin in a murine tumor model has been investigated. Fluorescence spectroscopy measurements were performed at several time intervals following drug administration, yielding information on the Temoporfin concentration within excised internal organs as a function of time after injection. Both point-monitoring and imaging setups were used. The acquired fluorescence data were correlated to the concentration of Temoporfin obtained with High Performance Liquid Chromatography (HPLC). There was a significant correlation between the fluorescence methods and HPLC for most organs investigated. The pharmacokinetics of this new liposomal formulation of Temoporfin exhibited a rather flat temporal profile in the time interval 2-8 hours in this study. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Flat temporal profile, Temoporfin, Liposomal formulation
host publication
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
volume
6427
pages
4270 - 4270
publisher
SPIE
conference name
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI
conference location
San Jose, CA, United States
conference dates
2007-01-20 - 2007-01-21
external identifiers
  • wos:000246489700020
  • scopus:34548238711
ISSN
1042-4687
1605-7422
DOI
10.1117/12.698932
language
English
LU publication?
yes
id
0f3c79a1-f3cd-4147-bd94-dc85e9dd199f (old id 643404)
date added to LUP
2016-04-01 12:24:49
date last changed
2025-01-02 17:04:07
@inproceedings{0f3c79a1-f3cd-4147-bd94-dc85e9dd199f,
  abstract     = {{Meso-tetra(hydroxyphenyl)chlorin (mTHPC) (international generic name Temoporfin) is a potent photosensitizer used for photodynamic therapy (PDT). In this study the pharmacokinetics of a systemically administered novel lipid formulation of Temoporfin in a murine tumor model has been investigated. Fluorescence spectroscopy measurements were performed at several time intervals following drug administration, yielding information on the Temoporfin concentration within excised internal organs as a function of time after injection. Both point-monitoring and imaging setups were used. The acquired fluorescence data were correlated to the concentration of Temoporfin obtained with High Performance Liquid Chromatography (HPLC). There was a significant correlation between the fluorescence methods and HPLC for most organs investigated. The pharmacokinetics of this new liposomal formulation of Temoporfin exhibited a rather flat temporal profile in the time interval 2-8 hours in this study.}},
  author       = {{Svensson, Jenny and Johansson, Ann and Bendsöe, Niels and Grafe, Susanna and Trebst, Tilmann and Andersson-Engels, Stefan and Svanberg, Katarina}},
  booktitle    = {{Progress in Biomedical Optics and Imaging - Proceedings of SPIE}},
  issn         = {{1042-4687}},
  keywords     = {{Flat temporal profile; Temoporfin; Liposomal formulation}},
  language     = {{eng}},
  pages        = {{4270--4270}},
  publisher    = {{SPIE}},
  title        = {{Pharmacokinetic study of a systemically administered novel liposomal Temoporfin formulation in an animal tumor model}},
  url          = {{https://lup.lub.lu.se/search/files/2913011/2370797.pdf}},
  doi          = {{10.1117/12.698932}},
  volume       = {{6427}},
  year         = {{2007}},
}