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Immunoreactive trypsin(Ogen) in the sera of children with recent-onset insulin-dependent diabetes and matched controls

Landin-Olsson, Mona LU ; Borgstrom, Anders ; Blom, Leif LU ; Sundkvist, Goran LU ; Lernmark, Ake LU orcid ; Nyström, L. ; Sandström, A. ; Wall, S. ; Aili, M. and Bäckman, H. , et al. (1990) In Pancreas 5(3). p.241-247
Abstract

To evaluate the exocrine pancreatic function at the time of diagnosis of insulin-dependent diabetes mellitus, we determined immunoreactive an-odal and cathodal trypsin(ogen) levels in sera from almost all children (n = 375) 0-14 years of age in Sweden in whom diabetes developed during 1 year, and in sex-, age-, and geographically matched control subjects (n = 312). The median level of anodal trypsin(ogen) was 5 (quartile range, 3-7) µg/L in children with newly diagnosed diabetes, compared with a median level of 7 (quartile range, 4-8) µg/L in control subjects (p < 0.0001). Similarly, the median level of cathodal trypsin(ogen) was 8 (quartile range, 4-10) µg/L in children with diabetes, compared with a median level of 11 (quartile... (More)

To evaluate the exocrine pancreatic function at the time of diagnosis of insulin-dependent diabetes mellitus, we determined immunoreactive an-odal and cathodal trypsin(ogen) levels in sera from almost all children (n = 375) 0-14 years of age in Sweden in whom diabetes developed during 1 year, and in sex-, age-, and geographically matched control subjects (n = 312). The median level of anodal trypsin(ogen) was 5 (quartile range, 3-7) µg/L in children with newly diagnosed diabetes, compared with a median level of 7 (quartile range, 4-8) µg/L in control subjects (p < 0.0001). Similarly, the median level of cathodal trypsin(ogen) was 8 (quartile range, 4-10) µg/L in children with diabetes, compared with a median level of 11 (quartile range, 7-15) µg/L in control subjects (p < 0.0001). The median of the individual ratios between cathodal and anodal trypsin(ogen) was 1.4 in the diabetic patients and 1.7 in the control children (p < 0.001). In a multivariate test, however, only the decrease in cathodal trypsin(ogen) concentration was associated with diabetes. The levels of trypsin(ogen)s did not correlate with levels of islet cell antibodies, present in 81% of the diabetic children. Several mechanisms may explain our findings, for example, similar pathogenetic factors may affect both the endocrine and exocrine pancreas simultaneously, a failing local trophic stimulation by insulin on the exocrine cells may decrease the trypsinogen production, and there may be an increased elimination of trypsin(ogen) because of higher filtration through the kidneys in the hyperglycemic state.

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author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
keywords
Anodal trypsin-(ogen), Case-control study, Cathodal trypsin(ogen), Exocrine pancreatic function, Insulin-dependent diabetic children
in
Pancreas
volume
5
issue
3
pages
241 - 247
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:2188253
  • scopus:0025265707
ISSN
0885-3177
DOI
10.1097/00006676-199005000-00001
language
English
LU publication?
yes
id
829ae736-8136-4d5a-aeb2-63766383fbc4
date added to LUP
2019-09-11 09:45:54
date last changed
2024-03-13 08:11:08
@article{829ae736-8136-4d5a-aeb2-63766383fbc4,
  abstract     = {{<p>To evaluate the exocrine pancreatic function at the time of diagnosis of insulin-dependent diabetes mellitus, we determined immunoreactive an-odal and cathodal trypsin(ogen) levels in sera from almost all children (n = 375) 0-14 years of age in Sweden in whom diabetes developed during 1 year, and in sex-, age-, and geographically matched control subjects (n = 312). The median level of anodal trypsin(ogen) was 5 (quartile range, 3-7) µg/L in children with newly diagnosed diabetes, compared with a median level of 7 (quartile range, 4-8) µg/L in control subjects (p &lt; 0.0001). Similarly, the median level of cathodal trypsin(ogen) was 8 (quartile range, 4-10) µg/L in children with diabetes, compared with a median level of 11 (quartile range, 7-15) µg/L in control subjects (p &lt; 0.0001). The median of the individual ratios between cathodal and anodal trypsin(ogen) was 1.4 in the diabetic patients and 1.7 in the control children (p &lt; 0.001). In a multivariate test, however, only the decrease in cathodal trypsin(ogen) concentration was associated with diabetes. The levels of trypsin(ogen)s did not correlate with levels of islet cell antibodies, present in 81% of the diabetic children. Several mechanisms may explain our findings, for example, similar pathogenetic factors may affect both the endocrine and exocrine pancreas simultaneously, a failing local trophic stimulation by insulin on the exocrine cells may decrease the trypsinogen production, and there may be an increased elimination of trypsin(ogen) because of higher filtration through the kidneys in the hyperglycemic state.</p>}},
  author       = {{Landin-Olsson, Mona and Borgstrom, Anders and Blom, Leif and Sundkvist, Goran and Lernmark, Ake and Nyström, L. and Sandström, A. and Wall, S. and Aili, M. and Bäckman, H. and Carlsson, E. and Edenwall, H. and Elfstrand, P. O. and Granström, B. W. and Gustavsson, I. and Gustavsson, L. E. and Hallberg, A. and Hansing, B. and Hanås, R. and Hellenberg, L. and Holmberg, E. and Hornell, H. and Jonsell, G. and Jönsson, C. and Kockum, K. and Lindberg, U. and Lindblad, B. and Ludvigsson, J. and Mazreliez, V. and Myrdal, U. and Neiderud, J. and Nilsson, K. O. and Persson, B. and Petzén, P. G. and Samuelsson, G. and Segnestam, K. and Sigurs, N. and Sjöblad, S. and Sjögren, S. and Skogsberg, L. and Smith, T. and Snellman, K. and Strömberg, L. and Ståle, U. and Tenstam, J. and Thalme, B. and Thilén, A. and Tullus, K. and Tuvemo, T. and Westphal, O.}},
  issn         = {{0885-3177}},
  keywords     = {{Anodal trypsin-(ogen); Case-control study; Cathodal trypsin(ogen); Exocrine pancreatic function; Insulin-dependent diabetic children}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{3}},
  pages        = {{241--247}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Pancreas}},
  title        = {{Immunoreactive trypsin(Ogen) in the sera of children with recent-onset insulin-dependent diabetes and matched controls}},
  url          = {{http://dx.doi.org/10.1097/00006676-199005000-00001}},
  doi          = {{10.1097/00006676-199005000-00001}},
  volume       = {{5}},
  year         = {{1990}},
}