Regulation of norepinephrine transporter and tyrosine hydroxylase mRNAs after kainic acid-induced seizures
(1999) In Brain Research 842(1). p.239-242- Abstract
Noradrenergic locus coeruleus (LC) efferents to the forebrain suppress seizures in several models of epilepsy. Using in situ hybridization, we demonstrate that tyrosine hydroxylase (TH) and norepinephrine transporter (NET) but not vesicular monoamine transporter 2 (VMAT2) mRNA levels are transiently elevated in LC neurons following kainic acid-induced status epilepticus. These increases of TH and NET mRNAs and presumably of the proteins themselves might enhance synthesis and reuptake of NE postictally.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8d1b3f24-6992-4c74-a7b4-913cec435841
- author
- Bengzon, Johan LU ; Hansson, Stefan R. LU ; Hoffman, Beth J. and Lindvall, Olle LU
- organization
- publishing date
- 1999-09-18
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Epilepsy, Locus coeruleus, Monoamine transporter, Norepinephrine, Rat
- in
- Brain Research
- volume
- 842
- issue
- 1
- pages
- 239 - 242
- publisher
- Elsevier
- external identifiers
-
- scopus:0033581345
- pmid:10526118
- ISSN
- 0006-8993
- DOI
- 10.1016/S0006-8993(99)01874-0
- language
- English
- LU publication?
- yes
- id
- 8d1b3f24-6992-4c74-a7b4-913cec435841
- date added to LUP
- 2019-06-04 16:04:52
- date last changed
- 2024-06-25 17:36:15
@article{8d1b3f24-6992-4c74-a7b4-913cec435841, abstract = {{<p>Noradrenergic locus coeruleus (LC) efferents to the forebrain suppress seizures in several models of epilepsy. Using in situ hybridization, we demonstrate that tyrosine hydroxylase (TH) and norepinephrine transporter (NET) but not vesicular monoamine transporter 2 (VMAT2) mRNA levels are transiently elevated in LC neurons following kainic acid-induced status epilepticus. These increases of TH and NET mRNAs and presumably of the proteins themselves might enhance synthesis and reuptake of NE postictally.</p>}}, author = {{Bengzon, Johan and Hansson, Stefan R. and Hoffman, Beth J. and Lindvall, Olle}}, issn = {{0006-8993}}, keywords = {{Epilepsy; Locus coeruleus; Monoamine transporter; Norepinephrine; Rat}}, language = {{eng}}, month = {{09}}, number = {{1}}, pages = {{239--242}}, publisher = {{Elsevier}}, series = {{Brain Research}}, title = {{Regulation of norepinephrine transporter and tyrosine hydroxylase mRNAs after kainic acid-induced seizures}}, url = {{http://dx.doi.org/10.1016/S0006-8993(99)01874-0}}, doi = {{10.1016/S0006-8993(99)01874-0}}, volume = {{842}}, year = {{1999}}, }