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Inhalation and dermal uptake of particle and gas phase phthalates - A human chamber exposure study

Andersen, Christina LU ; Krais, Annette M. LU orcid ; Eriksson, Axel C. LU orcid ; Jakobsson, Jonas LU ; Löndahl, Jakob LU orcid ; Lindh, Christian H. LU orcid ; Pagels, Joakim LU ; Nielsen, Jörn LU ; Gudmundsson, Anders LU and Wierzbicka, Aneta LU orcid (2018) 15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018 In 15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018
Abstract

We have exposed sixteen test subjects to particle and gas phase phthalates in the controlled chamber exposure study. Deuterium labelled phthalates were used to generate particle D4-DEHP (di(2-ethylhexyl) phthalate) and gas phase D4-DEP (diethyl phthalate) for exposures scenarios allowed studying the dermal only and combined inhalational and dermal uptake. Metabolites were measured in urine samples before and after three hours of exposure. The inhalation was the dominant route of uptake for both DEHP and DEP in this study design and exposure settings. Larger uptake of DEP compared to DEHP both via inhalation and dermal uptake was observed. Dermal uptake of DEHP was not observed in this study. Inhalational urinary excretion factors of the... (More)

We have exposed sixteen test subjects to particle and gas phase phthalates in the controlled chamber exposure study. Deuterium labelled phthalates were used to generate particle D4-DEHP (di(2-ethylhexyl) phthalate) and gas phase D4-DEP (diethyl phthalate) for exposures scenarios allowed studying the dermal only and combined inhalational and dermal uptake. Metabolites were measured in urine samples before and after three hours of exposure. The inhalation was the dominant route of uptake for both DEHP and DEP in this study design and exposure settings. Larger uptake of DEP compared to DEHP both via inhalation and dermal uptake was observed. Dermal uptake of DEHP was not observed in this study. Inhalational urinary excretion factors of the metabolites were found to be 0.73 for DEHP and 0.53 for DEP. This study also highlights the importance of taking into consideration the deposited dose of inhaled particles in studies of uptake of particles.

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author
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organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Dermal exposure, Inhalation, Lung deposition, Semi-volatile organic compounds (SVOCs)
host publication
15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018
series title
15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018
publisher
International Society of Indoor Air Quality and Climate (ISIAQ)
conference name
15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018
conference location
Philadelphia, United States
conference dates
2018-07-22 - 2018-07-27
external identifiers
  • scopus:85105644498
ISBN
9781713826514
language
English
LU publication?
yes
id
9fa076e0-57e1-4d21-9cbb-83d4ab370e70
date added to LUP
2021-05-28 14:58:04
date last changed
2023-08-29 21:05:14
@inproceedings{9fa076e0-57e1-4d21-9cbb-83d4ab370e70,
  abstract     = {{<p>We have exposed sixteen test subjects to particle and gas phase phthalates in the controlled chamber exposure study. Deuterium labelled phthalates were used to generate particle D4-DEHP (di(2-ethylhexyl) phthalate) and gas phase D4-DEP (diethyl phthalate) for exposures scenarios allowed studying the dermal only and combined inhalational and dermal uptake. Metabolites were measured in urine samples before and after three hours of exposure. The inhalation was the dominant route of uptake for both DEHP and DEP in this study design and exposure settings. Larger uptake of DEP compared to DEHP both via inhalation and dermal uptake was observed. Dermal uptake of DEHP was not observed in this study. Inhalational urinary excretion factors of the metabolites were found to be 0.73 for DEHP and 0.53 for DEP. This study also highlights the importance of taking into consideration the deposited dose of inhaled particles in studies of uptake of particles.</p>}},
  author       = {{Andersen, Christina and Krais, Annette M. and Eriksson, Axel C. and Jakobsson, Jonas and Löndahl, Jakob and Lindh, Christian H. and Pagels, Joakim and Nielsen, Jörn and Gudmundsson, Anders and Wierzbicka, Aneta}},
  booktitle    = {{15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018}},
  isbn         = {{9781713826514}},
  keywords     = {{Dermal exposure; Inhalation; Lung deposition; Semi-volatile organic compounds (SVOCs)}},
  language     = {{eng}},
  publisher    = {{International Society of Indoor Air Quality and Climate (ISIAQ)}},
  series       = {{15th Conference of the International Society of Indoor Air Quality and Climate, INDOOR AIR 2018}},
  title        = {{Inhalation and dermal uptake of particle and gas phase phthalates - A human chamber exposure study}},
  year         = {{2018}},
}