Monobutyrin Reduces Liver Cholesterol and Improves Intestinal Barrier Function in Rats Fed High-Fat Diets
(2019) In Nutrients 11(2).- Abstract
Butyric acid has been shown to reduce high-fat diet-related metabolic disturbances and to improve intestinal barrier function due to its potent anti-inflammatory capacity. This study investigates whether a butyric acid ester, monobutyrin (MB) affects lipid profiles and gut barrier function in a dose-response manner in rats fed butter- or lard-based high-fat diets. Four-week-old male Wistar rats were fed butter-based diets containing 0, 0.25, 0.75 and 1.5 MB g/100 g (dry weight basis) or 0.5 glycerol g/100 g, and diets with lard (La) containing 0 and 0.5 MB g/100 g or a low-fat control diet for 3⁻4 weeks. Lipid profiles in blood and liver tissue, intestinal permeability and cecal short-chain fatty acids were examined. The results showed... (More)
Butyric acid has been shown to reduce high-fat diet-related metabolic disturbances and to improve intestinal barrier function due to its potent anti-inflammatory capacity. This study investigates whether a butyric acid ester, monobutyrin (MB) affects lipid profiles and gut barrier function in a dose-response manner in rats fed butter- or lard-based high-fat diets. Four-week-old male Wistar rats were fed butter-based diets containing 0, 0.25, 0.75 and 1.5 MB g/100 g (dry weight basis) or 0.5 glycerol g/100 g, and diets with lard (La) containing 0 and 0.5 MB g/100 g or a low-fat control diet for 3⁻4 weeks. Lipid profiles in blood and liver tissue, intestinal permeability and cecal short-chain fatty acids were examined. The results showed a dose-dependent decrease in liver total cholesterol for 1.5 MB (p < 0.05) and liver triglycerides for 0.75 MB (p < 0.05) and 1.5 MB (p = 0.08) groups compared to the high-fat control group. Furthermore, a lower excretion of mannitol in urine in the 1.5 MB group indicated improved intestinal barrier function. When MB was supplemented in the lard-based diet, serum total cholesterol levels decreased, and total amount of liver high-density lipoprotein-cholesterol increased. Thus, MB dietary supplementation can be effective in counteracting lipid metabolism disturbances and impaired gut barrier function induced by high-fat diets.
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- author
- Nguyen, Thao Duy LU ; Prykhodko, Olena LU ; Hållenius, Frida F. LU and Nyman, Margareta LU
- organization
- publishing date
- 2019-02-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- butter, butyrate, cecal SCFA, intestinal permeability, lactulose/mannitol test, lard, lipid metabolism, Wistar rat
- in
- Nutrients
- volume
- 11
- issue
- 2
- publisher
- MDPI AG
- external identifiers
-
- scopus:85061141973
- pmid:30717248
- ISSN
- 2072-6643
- DOI
- 10.3390/nu11020308
- language
- English
- LU publication?
- yes
- id
- ad707022-5b1a-41d5-b767-cca4f085d0a4
- date added to LUP
- 2019-02-15 08:09:20
- date last changed
- 2024-04-16 00:33:38
@article{ad707022-5b1a-41d5-b767-cca4f085d0a4, abstract = {{<p>Butyric acid has been shown to reduce high-fat diet-related metabolic disturbances and to improve intestinal barrier function due to its potent anti-inflammatory capacity. This study investigates whether a butyric acid ester, monobutyrin (MB) affects lipid profiles and gut barrier function in a dose-response manner in rats fed butter- or lard-based high-fat diets. Four-week-old male Wistar rats were fed butter-based diets containing 0, 0.25, 0.75 and 1.5 MB g/100 g (dry weight basis) or 0.5 glycerol g/100 g, and diets with lard (La) containing 0 and 0.5 MB g/100 g or a low-fat control diet for 3⁻4 weeks. Lipid profiles in blood and liver tissue, intestinal permeability and cecal short-chain fatty acids were examined. The results showed a dose-dependent decrease in liver total cholesterol for 1.5 MB (p < 0.05) and liver triglycerides for 0.75 MB (p < 0.05) and 1.5 MB (p = 0.08) groups compared to the high-fat control group. Furthermore, a lower excretion of mannitol in urine in the 1.5 MB group indicated improved intestinal barrier function. When MB was supplemented in the lard-based diet, serum total cholesterol levels decreased, and total amount of liver high-density lipoprotein-cholesterol increased. Thus, MB dietary supplementation can be effective in counteracting lipid metabolism disturbances and impaired gut barrier function induced by high-fat diets.</p>}}, author = {{Nguyen, Thao Duy and Prykhodko, Olena and Hållenius, Frida F. and Nyman, Margareta}}, issn = {{2072-6643}}, keywords = {{butter; butyrate; cecal SCFA; intestinal permeability; lactulose/mannitol test; lard; lipid metabolism; Wistar rat}}, language = {{eng}}, month = {{02}}, number = {{2}}, publisher = {{MDPI AG}}, series = {{Nutrients}}, title = {{Monobutyrin Reduces Liver Cholesterol and Improves Intestinal Barrier Function in Rats Fed High-Fat Diets}}, url = {{http://dx.doi.org/10.3390/nu11020308}}, doi = {{10.3390/nu11020308}}, volume = {{11}}, year = {{2019}}, }