5-hydroxytryptamine in the endocrine pancreas
(2019) p.81-90- Abstract
The presence of serotonin (5-hydroxytryptamine [5-HT]) in pancreatic endocrine cells is well established. Nevertheless, recent advances are only now unraveling the signaling network involving 5-HT that partly regulates the release of hormones emanating from the islets of Langerhans. It is widely accepted that failure of the pancreatic β-cell to release sufficient amounts of insulin is the main culprit in the development of type 2 diabetes, an ongoing global epidemic. In this context, 5-HT signaling may play a crucial role. In fact, serotonin (5-HT) is part of an intricate signaling network regulating release of insulin and glucagon, the main hormones that control lipid and glucose homeostasis. Several studies have focused on the role of... (More)
The presence of serotonin (5-hydroxytryptamine [5-HT]) in pancreatic endocrine cells is well established. Nevertheless, recent advances are only now unraveling the signaling network involving 5-HT that partly regulates the release of hormones emanating from the islets of Langerhans. It is widely accepted that failure of the pancreatic β-cell to release sufficient amounts of insulin is the main culprit in the development of type 2 diabetes, an ongoing global epidemic. In this context, 5-HT signaling may play a crucial role. In fact, serotonin (5-HT) is part of an intricate signaling network regulating release of insulin and glucagon, the main hormones that control lipid and glucose homeostasis. Several studies have focused on the role of 5-HT and signaling through various 5-HT receptors in pancreatic β-cells and effects on overall glucose metabolism. Here, we aim to discuss some of these issues.
(Less)
- author
- Fex, Malin LU
- organization
- publishing date
- 2019
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- 5-HT receptors, Islets of Langerhans, α-cells insulin secretion, β-cells
- host publication
- Serotonin : The Mediator that Spans Evolution - The Mediator that Spans Evolution
- editor
- Pilowsky, Paul M
- pages
- 10 pages
- publisher
- Academic Press
- external identifiers
-
- scopus:85080811936
- ISBN
- 9780128000502
- DOI
- 10.1016/B978-0-12-800050-2.00004-8
- language
- English
- LU publication?
- yes
- id
- aeeeb30e-7c98-4fed-a3dc-f9de1dd9aa02
- date added to LUP
- 2020-03-26 15:53:58
- date last changed
- 2022-02-01 05:15:20
@inbook{aeeeb30e-7c98-4fed-a3dc-f9de1dd9aa02,
abstract = {{<p>The presence of serotonin (5-hydroxytryptamine [5-HT]) in pancreatic endocrine cells is well established. Nevertheless, recent advances are only now unraveling the signaling network involving 5-HT that partly regulates the release of hormones emanating from the islets of Langerhans. It is widely accepted that failure of the pancreatic β-cell to release sufficient amounts of insulin is the main culprit in the development of type 2 diabetes, an ongoing global epidemic. In this context, 5-HT signaling may play a crucial role. In fact, serotonin (5-HT) is part of an intricate signaling network regulating release of insulin and glucagon, the main hormones that control lipid and glucose homeostasis. Several studies have focused on the role of 5-HT and signaling through various 5-HT receptors in pancreatic β-cells and effects on overall glucose metabolism. Here, we aim to discuss some of these issues.</p>}},
author = {{Fex, Malin}},
booktitle = {{Serotonin : The Mediator that Spans Evolution}},
editor = {{Pilowsky, Paul M}},
isbn = {{9780128000502}},
keywords = {{5-HT receptors; Islets of Langerhans; α-cells insulin secretion; β-cells}},
language = {{eng}},
pages = {{81--90}},
publisher = {{Academic Press}},
title = {{5-hydroxytryptamine in the endocrine pancreas}},
url = {{http://dx.doi.org/10.1016/B978-0-12-800050-2.00004-8}},
doi = {{10.1016/B978-0-12-800050-2.00004-8}},
year = {{2019}},
}