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Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort

Molina-Montes, Esther ; Sánchez, María José ; Zamora-Ros, Raul ; Bueno-de-Mesquita, H. Bas ; Wark, Petra A. ; Obon-Santacana, Mireia ; Kühn, Tilman ; Katzke, Verena ; Travis, Ruth C. and Ye, Weimin , et al. (2016) In International Journal of Cancer 139(7). p.1480-1492
Abstract

Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine pancreatic cancer cases occurred after 11.3 years of follow-up of 477,309 cohort members. Dietary flavonoid and lignan intake was estimated through validated dietary questionnaires and the US Department of Agriculture (USDA) and Phenol Explorer databases. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated using age, sex and... (More)

Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine pancreatic cancer cases occurred after 11.3 years of follow-up of 477,309 cohort members. Dietary flavonoid and lignan intake was estimated through validated dietary questionnaires and the US Department of Agriculture (USDA) and Phenol Explorer databases. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated using age, sex and center-stratified Cox proportional hazards models, adjusted for energy intake, body mass index (BMI), smoking, alcohol and diabetes status. Our results showed that neither overall dietary intake of flavonoids nor of lignans were associated with pancreatic cancer risk (multivariable-adjusted HR for a doubling of intake = 1.03, 95% CI: 0.95–1.11 and 1.02; 95% CI: 0.89–1.17, respectively). Statistically significant associations were also not observed by flavonoid subclasses. An inverse association between intake of flavanones and pancreatic cancer risk was apparent, without reaching statistical significance, in microscopically confirmed cases (HR for a doubling of intake = 0.96, 95% CI: 0.91–1.00). In conclusion, we did not observe an association between intake of flavonoids, flavonoid subclasses or lignans and pancreatic cancer risk in the EPIC cohort.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cohort, diet, flavonoids, lignans, pancreatic cancer
in
International Journal of Cancer
volume
139
issue
7
pages
13 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:27184434
  • wos:000379977200005
  • scopus:84978296091
ISSN
0020-7136
DOI
10.1002/ijc.30190
language
English
LU publication?
yes
id
af546b93-5b47-4066-95d8-48d2a105a69f
date added to LUP
2016-08-01 11:41:52
date last changed
2024-05-03 07:44:32
@article{af546b93-5b47-4066-95d8-48d2a105a69f,
  abstract     = {{<p>Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine pancreatic cancer cases occurred after 11.3 years of follow-up of 477,309 cohort members. Dietary flavonoid and lignan intake was estimated through validated dietary questionnaires and the US Department of Agriculture (USDA) and Phenol Explorer databases. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated using age, sex and center-stratified Cox proportional hazards models, adjusted for energy intake, body mass index (BMI), smoking, alcohol and diabetes status. Our results showed that neither overall dietary intake of flavonoids nor of lignans were associated with pancreatic cancer risk (multivariable-adjusted HR for a doubling of intake = 1.03, 95% CI: 0.95–1.11 and 1.02; 95% CI: 0.89–1.17, respectively). Statistically significant associations were also not observed by flavonoid subclasses. An inverse association between intake of flavanones and pancreatic cancer risk was apparent, without reaching statistical significance, in microscopically confirmed cases (HR for a doubling of intake = 0.96, 95% CI: 0.91–1.00). In conclusion, we did not observe an association between intake of flavonoids, flavonoid subclasses or lignans and pancreatic cancer risk in the EPIC cohort.</p>}},
  author       = {{Molina-Montes, Esther and Sánchez, María José and Zamora-Ros, Raul and Bueno-de-Mesquita, H. Bas and Wark, Petra A. and Obon-Santacana, Mireia and Kühn, Tilman and Katzke, Verena and Travis, Ruth C. and Ye, Weimin and Sund, Malin and Naccarati, Alessio and Mattiello, Amalia and Krogh, Vittorio and Martorana, Caterina and Masala, Giovanna and Amiano, Pilar and Huerta, José María and Barricarte, Aurelio and Quirós, José Ramón and Weiderpass, Elisabete and Angell Åsli, Lene and Skeie, Guri and Ericson, Ulrika and Sonestedt, Emily and Peeters, Petra H. and Romieu, Isabelle and Scalbert, Augustin and Overvad, Kim and Clemens, Matthias and Boeing, Heiner and Trichopoulou, Antonia and Peppa, Eleni and Vidalis, Pavlos and Khaw, Kay Tee and Wareham, Nick and Olsen, Anja and Tjønneland, Anne and Boutroun-Rualt, Marie Christine and Clavel-Chapelon, Françoise and Cross, Amanda J. and Lu, Yunxia and Riboli, Elio and Duell, Eric J.}},
  issn         = {{0020-7136}},
  keywords     = {{cohort; diet; flavonoids; lignans; pancreatic cancer}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{7}},
  pages        = {{1480--1492}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort}},
  url          = {{http://dx.doi.org/10.1002/ijc.30190}},
  doi          = {{10.1002/ijc.30190}},
  volume       = {{139}},
  year         = {{2016}},
}