Vitamin D intervention and bone : A randomized clinical trial in fair- and dark-skinned children at northern latitudes
(2018) In Journal of Pediatric Gastroenterology and Nutrition 67(3). p.388-394- Abstract
Objectives: The aim of the study was to evaluate vitamin D status and effects of vitamin D intervention on bone mineral density (BMD) and content (BMC) in children with fair and dark skin in Sweden during winter. Methods: In a 2-center prospective double-blinded randomized intervention study 5- to 7-year-old children (n=206) with fair and dark skin in Sweden (55°N-63°N) received daily vitamin D supplements of 25μg, 10μg, or placebo (2μg) during 3 winter months. We measured BMD and BMC for total body (TB), total body less head (TBLH), femoral neck (FN), and spine at baseline and 4 months later. Intake of vitamin D and calcium, serum 25- hydroxy vitamin D (S-25[OH]D), and related parameters were analyzed. Results: Despite lower S-25(OH)D... (More)
Objectives: The aim of the study was to evaluate vitamin D status and effects of vitamin D intervention on bone mineral density (BMD) and content (BMC) in children with fair and dark skin in Sweden during winter. Methods: In a 2-center prospective double-blinded randomized intervention study 5- to 7-year-old children (n=206) with fair and dark skin in Sweden (55°N-63°N) received daily vitamin D supplements of 25μg, 10μg, or placebo (2μg) during 3 winter months. We measured BMD and BMC for total body (TB), total body less head (TBLH), femoral neck (FN), and spine at baseline and 4 months later. Intake of vitamin D and calcium, serum 25- hydroxy vitamin D (S-25[OH]D), and related parameters were analyzed. Results: Despite lower S-25(OH)D in dark than fair-skinned children, BMD of TB (P=0.012) and TBLH (P=0.002) and BMC of TBLH (P=0.04) were higher at baseline and follow-up in those with dark skin. Delta (Δ) BMD and BMC of TB and TBLH did not differ between intervention and placebo groups, but FN-BMC increased more among dark-skinned children in the 25μg (P=0.038) and 10μg (P=0.027) groups compared to placebo. We found no associations between Δ S-25(OH)D, P-parathyroid hormone, P-alkaline phosphatase, and D BMD and BMC, respectively. Conclusions: BMD and BMC remained higher in dark- than fair-skinned children despite lower vitamin D status. Even though no difference in general was found in BMD or BMC after vitamin D intervention, the increase in FN-BMC in dark-skinned children may suggest an influence on bone in those with initially insufficient vitamin D status.
(Less)
- author
- Åkeson, Pia Karlsland LU ; Åkesson, Kristina E. LU ; Lind, Torbjörn ; Hernell, Olle ; Silfverdal, Sven Arne and Öhlund, Inger
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 25-hydroxyvitamin D, Bone mineral content, Bone mineral density, Child, Skin color
- in
- Journal of Pediatric Gastroenterology and Nutrition
- volume
- 67
- issue
- 3
- pages
- 7 pages
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- scopus:85056758094
- pmid:29851760
- ISSN
- 0277-2116
- DOI
- 10.1097/MPG.0000000000002031
- language
- English
- LU publication?
- yes
- id
- af7daa67-810d-47c0-a1cc-51d0b0863f53
- date added to LUP
- 2018-11-28 10:50:45
- date last changed
- 2024-07-23 04:04:04
@article{af7daa67-810d-47c0-a1cc-51d0b0863f53, abstract = {{<p>Objectives: The aim of the study was to evaluate vitamin D status and effects of vitamin D intervention on bone mineral density (BMD) and content (BMC) in children with fair and dark skin in Sweden during winter. Methods: In a 2-center prospective double-blinded randomized intervention study 5- to 7-year-old children (n=206) with fair and dark skin in Sweden (55°N-63°N) received daily vitamin D supplements of 25μg, 10μg, or placebo (2μg) during 3 winter months. We measured BMD and BMC for total body (TB), total body less head (TBLH), femoral neck (FN), and spine at baseline and 4 months later. Intake of vitamin D and calcium, serum 25- hydroxy vitamin D (S-25[OH]D), and related parameters were analyzed. Results: Despite lower S-25(OH)D in dark than fair-skinned children, BMD of TB (P=0.012) and TBLH (P=0.002) and BMC of TBLH (P=0.04) were higher at baseline and follow-up in those with dark skin. Delta (Δ) BMD and BMC of TB and TBLH did not differ between intervention and placebo groups, but FN-BMC increased more among dark-skinned children in the 25μg (P=0.038) and 10μg (P=0.027) groups compared to placebo. We found no associations between Δ S-25(OH)D, P-parathyroid hormone, P-alkaline phosphatase, and D BMD and BMC, respectively. Conclusions: BMD and BMC remained higher in dark- than fair-skinned children despite lower vitamin D status. Even though no difference in general was found in BMD or BMC after vitamin D intervention, the increase in FN-BMC in dark-skinned children may suggest an influence on bone in those with initially insufficient vitamin D status.</p>}}, author = {{Åkeson, Pia Karlsland and Åkesson, Kristina E. and Lind, Torbjörn and Hernell, Olle and Silfverdal, Sven Arne and Öhlund, Inger}}, issn = {{0277-2116}}, keywords = {{25-hydroxyvitamin D; Bone mineral content; Bone mineral density; Child; Skin color}}, language = {{eng}}, number = {{3}}, pages = {{388--394}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{Journal of Pediatric Gastroenterology and Nutrition}}, title = {{Vitamin D intervention and bone : A randomized clinical trial in fair- and dark-skinned children at northern latitudes}}, url = {{http://dx.doi.org/10.1097/MPG.0000000000002031}}, doi = {{10.1097/MPG.0000000000002031}}, volume = {{67}}, year = {{2018}}, }