Immune response in blood before and after epileptic and psychogenic non-epileptic seizures
(2023) In Heliyon 9(3).- Abstract
Inflammatory processes may provoke epileptic seizures and seizures may promote an immune reaction. Hence, the systemic immune reaction is a tempting diagnostic and prognostic marker in epilepsy. We explored the immune response before and after epileptic and psychogenic non-epileptic seizures (PNES). Serum samples collected from patients with videoEEG-verified temporal or frontal lobe epilepsy (TLE or FLE) or TLE + PNES showed increased interleukin-6 (IL-6) levels in between seizures (interictally), compared to controls. Patients with PNES had no increase in IL-6. The IL-6 levels increased transiently even further within hours after a seizure (postictally) in TLE but not in FLE patients. The postictal to interictal ratio of... (More)
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Inflammatory processes may provoke epileptic seizures and seizures may promote an immune reaction. Hence, the systemic immune reaction is a tempting diagnostic and prognostic marker in epilepsy. We explored the immune response before and after epileptic and psychogenic non-epileptic seizures (PNES). Serum samples collected from patients with videoEEG-verified temporal or frontal lobe epilepsy (TLE or FLE) or TLE + PNES showed increased interleukin-6 (IL-6) levels in between seizures (interictally), compared to controls. Patients with PNES had no increase in IL-6. The IL-6 levels increased transiently even further within hours after a seizure (postictally) in TLE but not in FLE patients. The postictal to interictal ratio of additionally five immune factors were also increased in TLE patients only. We conclude that immune factors have the potential to be future biomarkers for epileptic seizures and that the heterogeneity among different epileptic and non-epileptic seizures may be disclosed in peripheral blood sampling independent of co-morbidities.
- author
- Ahl, Matilda LU ; Taylor, Marie K LU ; Avdic, Una ; Lundin, Anna LU ; Andersson, My LU ; Amandusson, Åsa ; Kumlien, Eva ; Compagno Strandberg, Maria LU and Ekdahl, Christine T LU
- organization
-
- Clinical Neurophysiology
- Epilepsy Center
- Inflammation and Stemcell Therapy Group (research group)
- Brain Repair and Imaging in Neural Systems (BRAINS) (research group)
- EpiHealth: Epidemiology for Health
- Cellular Neurophysiology and Epilepsy group (research group)
- Neurology, Lund
- Clinical Epilepsy Research (research group)
- publishing date
- 2023-03
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Heliyon
- volume
- 9
- issue
- 3
- article number
- e13938
- publisher
- Elsevier
- external identifiers
-
- scopus:85148723098
- pmid:36895367
- ISSN
- 2405-8440
- DOI
- 10.1016/j.heliyon.2023.e13938
- language
- English
- LU publication?
- yes
- additional info
- © 2023 The Authors. Published by Elsevier Ltd.
- id
- b7f8d08b-2ad5-4637-afbb-3ae178e13500
- date added to LUP
- 2023-03-13 09:27:36
- date last changed
- 2024-09-02 14:04:05
@article{b7f8d08b-2ad5-4637-afbb-3ae178e13500, abstract = {{<p><br> Inflammatory processes may provoke epileptic seizures and seizures may promote an immune reaction. Hence, the systemic immune reaction is a tempting diagnostic and prognostic marker in epilepsy. We explored the immune response before and after epileptic and psychogenic non-epileptic seizures (PNES). Serum samples collected from patients with videoEEG-verified temporal or frontal lobe epilepsy (TLE or FLE) or TLE + PNES showed increased interleukin-6 (IL-6) levels in between seizures (interictally), compared to controls. Patients with PNES had no increase in IL-6. The IL-6 levels increased transiently even further within hours after a seizure (postictally) in TLE but not in FLE patients. The postictal to interictal ratio of additionally five immune factors were also increased in TLE patients only. We conclude that immune factors have the potential to be future biomarkers for epileptic seizures and that the heterogeneity among different epileptic and non-epileptic seizures may be disclosed in peripheral blood sampling independent of co-morbidities.<br> </p>}}, author = {{Ahl, Matilda and Taylor, Marie K and Avdic, Una and Lundin, Anna and Andersson, My and Amandusson, Åsa and Kumlien, Eva and Compagno Strandberg, Maria and Ekdahl, Christine T}}, issn = {{2405-8440}}, language = {{eng}}, number = {{3}}, publisher = {{Elsevier}}, series = {{Heliyon}}, title = {{Immune response in blood before and after epileptic and psychogenic non-epileptic seizures}}, url = {{http://dx.doi.org/10.1016/j.heliyon.2023.e13938}}, doi = {{10.1016/j.heliyon.2023.e13938}}, volume = {{9}}, year = {{2023}}, }