Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Genetic Susceptibility to Mood Disorders and Risk of Stroke : A Polygenic Risk Score and Mendelian Randomization Study

Sun, Jiangming LU orcid ; Borné, Yan LU ; Edsfeldt, Andreas LU ; Wang, Yunpeng ; Pan, Mengyu LU orcid ; Melander, Olle LU orcid ; Engström, Gunnar LU and Gonçalves, Isabel LU orcid (2023) In Stroke 54(5). p.1340-1346
Abstract

BACKGROUND: Mood disorders and strokes are often comorbid, and their health toll worldwide is huge. This study characterizes prognostic and causal roles of mood disorders in stroke.

METHODS: We tested if genetic susceptibilities for mood disorders were associated with all strokes, ischemic strokes in the Malmö Diet and Cancer cohort (24 631 individuals with a median follow-up of 21.3 (interquartile range: 16.6-23.2) years. We further examined the causal effects for mood disorders on all strokes and ischemic strokes using summary statistics from large genome-wide association studies of mood disorders (up to 609 424 individuals, Psychiatric Genomics Consortium), all strokes and ischemic strokes (up to 446 696 individuals, MEGASTROKE... (More)

BACKGROUND: Mood disorders and strokes are often comorbid, and their health toll worldwide is huge. This study characterizes prognostic and causal roles of mood disorders in stroke.

METHODS: We tested if genetic susceptibilities for mood disorders were associated with all strokes, ischemic strokes in the Malmö Diet and Cancer cohort (24 631 individuals with a median follow-up of 21.3 (interquartile range: 16.6-23.2) years. We further examined the causal effects for mood disorders on all strokes and ischemic strokes using summary statistics from large genome-wide association studies of mood disorders (up to 609 424 individuals, Psychiatric Genomics Consortium), all strokes and ischemic strokes (up to 446 696 individuals, MEGASTROKE Consortium).

RESULTS: Among 24 366 stroke-free participants at baseline, 2632 individuals developed strokes, 2172 of them ischemic, during follow-up. After properly adjusting for well-known risk factors, participants in the highest quintile of polygenic risk scores for mood disorders had 1.45× (95% CI, 1.21-1.74) higher risk of strokes and 1.44× (95% CI, 1.18-1.76) higher risk of ischemic strokes compared with the lowest quintile in women. Mendelian randomization analyses suggested that mood disorders had a causal effect on strokes (odds ratio, 1.07 [95% CI, 1.03-1.11]) and ischemic strokes (odds ratio, 1.09 [95% CI, 1.04-1.13]).

CONCLUSIONS: Our results suggest a causal role of mood disorders in the risk of stroke. High-risk women could be identified early in life using polygenic risk scores to ultimately prevent mood disorders and strokes.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Stroke
volume
54
issue
5
pages
1340 - 1346
publisher
American Heart Association
external identifiers
  • pmid:36942587
  • scopus:85153804494
ISSN
1524-4628
DOI
10.1161/STROKEAHA.122.041026
language
English
LU publication?
yes
id
c2df21cd-0fd8-49d8-9dac-bdc2f9fbe854
date added to LUP
2023-03-25 10:30:03
date last changed
2024-01-19 21:02:57
@article{c2df21cd-0fd8-49d8-9dac-bdc2f9fbe854,
  abstract     = {{<p>BACKGROUND: Mood disorders and strokes are often comorbid, and their health toll worldwide is huge. This study characterizes prognostic and causal roles of mood disorders in stroke.</p><p>METHODS: We tested if genetic susceptibilities for mood disorders were associated with all strokes, ischemic strokes in the Malmö Diet and Cancer cohort (24 631 individuals with a median follow-up of 21.3 (interquartile range: 16.6-23.2) years. We further examined the causal effects for mood disorders on all strokes and ischemic strokes using summary statistics from large genome-wide association studies of mood disorders (up to 609 424 individuals, Psychiatric Genomics Consortium), all strokes and ischemic strokes (up to 446 696 individuals, MEGASTROKE Consortium).</p><p>RESULTS: Among 24 366 stroke-free participants at baseline, 2632 individuals developed strokes, 2172 of them ischemic, during follow-up. After properly adjusting for well-known risk factors, participants in the highest quintile of polygenic risk scores for mood disorders had 1.45× (95% CI, 1.21-1.74) higher risk of strokes and 1.44× (95% CI, 1.18-1.76) higher risk of ischemic strokes compared with the lowest quintile in women. Mendelian randomization analyses suggested that mood disorders had a causal effect on strokes (odds ratio, 1.07 [95% CI, 1.03-1.11]) and ischemic strokes (odds ratio, 1.09 [95% CI, 1.04-1.13]).</p><p>CONCLUSIONS: Our results suggest a causal role of mood disorders in the risk of stroke. High-risk women could be identified early in life using polygenic risk scores to ultimately prevent mood disorders and strokes.</p>}},
  author       = {{Sun, Jiangming and Borné, Yan and Edsfeldt, Andreas and Wang, Yunpeng and Pan, Mengyu and Melander, Olle and Engström, Gunnar and Gonçalves, Isabel}},
  issn         = {{1524-4628}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{1340--1346}},
  publisher    = {{American Heart Association}},
  series       = {{Stroke}},
  title        = {{Genetic Susceptibility to Mood Disorders and Risk of Stroke : A Polygenic Risk Score and Mendelian Randomization Study}},
  url          = {{http://dx.doi.org/10.1161/STROKEAHA.122.041026}},
  doi          = {{10.1161/STROKEAHA.122.041026}},
  volume       = {{54}},
  year         = {{2023}},
}