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T1w/T2w Ratio and Cognition in 9-to-11-Year-Old Children

Langensee, Lara LU ; Rumetshofer, Theodor LU orcid ; Behjat, Hamid LU ; Novén, Mikael LU ; Li, Ping LU and Mårtensson, Johan LU (2022) In Brain Sciences 12(5).
Abstract

Childhood is a period of extensive cortical and neural development. Among other things, axons in the brain gradually become more myelinated, promoting the propagation of electrical sig-nals between different parts of the brain, which in turn may facilitate skill development. Myelin is difficult to assess in vivo, and measurement techniques are only just beginning to make their way into standard imaging protocols in human cognitive neuroscience. An approach that has been proposed as an indirect measure of cortical myelin is the T1w/T2w ratio, a contrast that is based on the intensities of two standard structural magnetic resonance images. Although not initially intended as such, researchers have recently started to use the T1w/T2w... (More)

Childhood is a period of extensive cortical and neural development. Among other things, axons in the brain gradually become more myelinated, promoting the propagation of electrical sig-nals between different parts of the brain, which in turn may facilitate skill development. Myelin is difficult to assess in vivo, and measurement techniques are only just beginning to make their way into standard imaging protocols in human cognitive neuroscience. An approach that has been proposed as an indirect measure of cortical myelin is the T1w/T2w ratio, a contrast that is based on the intensities of two standard structural magnetic resonance images. Although not initially intended as such, researchers have recently started to use the T1w/T2w contrast for between-subject comparisons of cortical data with various behavioral and cognitive indices. As a complement to these earlier findings, we computed individual cortical T1w/T2w maps using data from the Adolescent Brain Cognitive Development study (N = 960; 449 females; aged 8.9 to 11.0 years) and related the T1w/T2w maps to indices of cognitive ability; in contrast to previous work, we did not find significant relationships between T1w/T2w values and cognitive performance after correcting for multiple testing. These findings reinforce existent skepticism about the applicability of T1w/T2w ratio for inter-indi-vidual comparisons.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cognitive abilities, intracortical myelin, neurocognition, structural MRI, T1w/T2w ratio
in
Brain Sciences
volume
12
issue
5
article number
599
publisher
MDPI AG
external identifiers
  • scopus:85130306080
  • pmid:35624986
ISSN
2076-3425
DOI
10.3390/brainsci12050599
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
id
de88aa84-216f-4555-9bf1-dde039e22882
date added to LUP
2022-12-08 11:23:56
date last changed
2024-07-10 18:31:20
@article{de88aa84-216f-4555-9bf1-dde039e22882,
  abstract     = {{<p>Childhood is a period of extensive cortical and neural development. Among other things, axons in the brain gradually become more myelinated, promoting the propagation of electrical sig-nals between different parts of the brain, which in turn may facilitate skill development. Myelin is difficult to assess in vivo, and measurement techniques are only just beginning to make their way into standard imaging protocols in human cognitive neuroscience. An approach that has been proposed as an indirect measure of cortical myelin is the T1w/T2w ratio, a contrast that is based on the intensities of two standard structural magnetic resonance images. Although not initially intended as such, researchers have recently started to use the T1w/T2w contrast for between-subject comparisons of cortical data with various behavioral and cognitive indices. As a complement to these earlier findings, we computed individual cortical T1w/T2w maps using data from the Adolescent Brain Cognitive Development study (N = 960; 449 females; aged 8.9 to 11.0 years) and related the T1w/T2w maps to indices of cognitive ability; in contrast to previous work, we did not find significant relationships between T1w/T2w values and cognitive performance after correcting for multiple testing. These findings reinforce existent skepticism about the applicability of T1w/T2w ratio for inter-indi-vidual comparisons.</p>}},
  author       = {{Langensee, Lara and Rumetshofer, Theodor and Behjat, Hamid and Novén, Mikael and Li, Ping and Mårtensson, Johan}},
  issn         = {{2076-3425}},
  keywords     = {{cognitive abilities; intracortical myelin; neurocognition; structural MRI; T1w/T2w ratio}},
  language     = {{eng}},
  number       = {{5}},
  publisher    = {{MDPI AG}},
  series       = {{Brain Sciences}},
  title        = {{T1w/T2w Ratio and Cognition in 9-to-11-Year-Old Children}},
  url          = {{http://dx.doi.org/10.3390/brainsci12050599}},
  doi          = {{10.3390/brainsci12050599}},
  volume       = {{12}},
  year         = {{2022}},
}