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Neural tissue xenotransplantation : What Is Needed Prior to Clinical Trials in Parkinson’s Disease?

Barker, R A LU ; Kendall, A L and Widner, Håkan LU (2000) In Cell Transplantation 9(2). p.46-235
Abstract

Embryonic allografted human tissue in patients with Parkinson's disease has been shown to survive and ameliorate many of the symptoms of this disease. Despite this success, the practical problems of using this tissue coupled to the ethical restrictions of using aborted human fetal tissue have lead to an exploration for alternative sources of suitable material for grafting, including xenogeneic embryonic dopaminergic-rich neural tissue. Nevertheless, xenografted neural tissue itself generates a number of practical, ethical, safety, and immunological issues that have to be addressed prior to any clinical xenotransplant program. In this article we review these critical issues and set out the criteria that we consider need to be met in the... (More)

Embryonic allografted human tissue in patients with Parkinson's disease has been shown to survive and ameliorate many of the symptoms of this disease. Despite this success, the practical problems of using this tissue coupled to the ethical restrictions of using aborted human fetal tissue have lead to an exploration for alternative sources of suitable material for grafting, including xenogeneic embryonic dopaminergic-rich neural tissue. Nevertheless, xenografted neural tissue itself generates a number of practical, ethical, safety, and immunological issues that have to be addressed prior to any clinical xenotransplant program. In this article we review these critical issues and set out the criteria that we consider need to be met in the development of our clinical xenotransplantation research programs. We advocate that these, or similar, criteria should be adopted and made explicit by other centers contemplating similar clinical trials.

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Contribution to journal
publication status
published
subject
keywords
Animals, Brain Tissue Transplantation, Cell Transplantation, Clinical Trials as Topic, Endogenous Retroviruses, Fetal Tissue Transplantation, Gestational Age, Graft Survival, Humans, Immunosuppression, Parkinson Disease, Risk Assessment, Safety, Specific Pathogen-Free Organisms, Swine, Transplantation, Heterologous, Journal Article, Review
in
Cell Transplantation
volume
9
issue
2
pages
12 pages
publisher
Cognizant Communication Corporation
external identifiers
  • scopus:0034070943
  • pmid:10811396
ISSN
0963-6897
language
English
LU publication?
yes
id
e55bba8d-94ee-465c-8fd5-01a1b0e6fca9
date added to LUP
2017-04-19 18:21:12
date last changed
2024-10-14 04:27:50
@article{e55bba8d-94ee-465c-8fd5-01a1b0e6fca9,
  abstract     = {{<p>Embryonic allografted human tissue in patients with Parkinson's disease has been shown to survive and ameliorate many of the symptoms of this disease. Despite this success, the practical problems of using this tissue coupled to the ethical restrictions of using aborted human fetal tissue have lead to an exploration for alternative sources of suitable material for grafting, including xenogeneic embryonic dopaminergic-rich neural tissue. Nevertheless, xenografted neural tissue itself generates a number of practical, ethical, safety, and immunological issues that have to be addressed prior to any clinical xenotransplant program. In this article we review these critical issues and set out the criteria that we consider need to be met in the development of our clinical xenotransplantation research programs. We advocate that these, or similar, criteria should be adopted and made explicit by other centers contemplating similar clinical trials.</p>}},
  author       = {{Barker, R A and Kendall, A L and Widner, Håkan}},
  issn         = {{0963-6897}},
  keywords     = {{Animals; Brain Tissue Transplantation; Cell Transplantation; Clinical Trials as Topic; Endogenous Retroviruses; Fetal Tissue Transplantation; Gestational Age; Graft Survival; Humans; Immunosuppression; Parkinson Disease; Risk Assessment; Safety; Specific Pathogen-Free Organisms; Swine; Transplantation, Heterologous; Journal Article; Review}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{2}},
  pages        = {{46--235}},
  publisher    = {{Cognizant Communication Corporation}},
  series       = {{Cell Transplantation}},
  title        = {{Neural tissue xenotransplantation : What Is Needed Prior to Clinical Trials in Parkinson’s Disease?}},
  volume       = {{9}},
  year         = {{2000}},
}