Role of Proneurotensin in Cardiometabolic Diseases
(2022) In Lund University, Faculty of Medicine Doctoral Dissertation Series- Abstract
- The burden of cardiometabolic diseases is increasing worldwide. Early detection of high-risk individuals is essential for appropriate diagnosis, better treatment outcomes, quality of life and lower health related costs. Aims: The overall aim of this thesis is to investigate the possible associations between plasma proneurotensin (Pro-NT) and risk of cardiovascular disease (CVD), type 2 diabetes (T2D), impaired glucose regulation, as well as diet-induced obesity in different study populations. As Pro-NT appears to be a novel risk marker for cardiometabolic morbidity and mortality, we also wanted to study the effects of dietary fat intake on circulating plasma Pro-NT and triglyceride levels. This thesis is based on epidemiological data from... (More)
- The burden of cardiometabolic diseases is increasing worldwide. Early detection of high-risk individuals is essential for appropriate diagnosis, better treatment outcomes, quality of life and lower health related costs. Aims: The overall aim of this thesis is to investigate the possible associations between plasma proneurotensin (Pro-NT) and risk of cardiovascular disease (CVD), type 2 diabetes (T2D), impaired glucose regulation, as well as diet-induced obesity in different study populations. As Pro-NT appears to be a novel risk marker for cardiometabolic morbidity and mortality, we also wanted to study the effects of dietary fat intake on circulating plasma Pro-NT and triglyceride levels. This thesis is based on epidemiological data from three population-based cohorts, The Malmö Preventive Project (MPP), The Malmö Diet and Cancer study- Cardiovascular Cohort (MDC-CC) and The MEDIM cohort (impact of Migration and Ethnicity on Diabetes in Malmö). Paper I, in this cohort including an elderly population, we identified that Pro-NT predicts incident CVD in both genders, but incident T2D in women only, after 5.4 years of follow up. Paper II, in a population based cohort of Iraqi and Swedish born men and women, higher Pro-NT levels were observed both in the Iraqi- vs Swedish-born group. However, elevated plasma Pro-NT was associated with impaired glucose regulations assessed as insulin secretion and action and HbA1c in the Iraqi-population only. Paper III, we found prompt increases in plasma Pro-NT every hour for four hours, after an oral lipid load in healthy individuals. Post-lipid rise of circulating plasma Pro-NT correlated with the changes in plasma triglyceride levels, irrespective of cream and olive oil. Paper IV, in this longitudinal study, we identified that high Pro-NT levels predicted all-cause mortality (ACM) and cause- specific mortalities (CSM) due to CVD, gastrointestinaltract (GIT) diseases, mental and behavioral diseases, and diseases of unspecific causes, in both gender. Conclusion: This thesis shows that circulating Pro-NT is a biomarker that in an elderly population predicts CVD in both gender, but T2D in women only . Irrespective of gender, Pro-NT predicts ACM and CSM. Pro-NT is more strongly associated with impaired glucose regulation in a Middle Eastern immigrant population and may partly explain the increased T2D in this group. Furthermore, oral lipid intake increases Pro-NT levels, which facilitates triglyceride increase in blood in healthy individuals, supporting intestinal lipid absorption as being one key action of Pro-NT. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/e5bcd83a-1f3f-4a32-a1a0-c1fd588e4bbb
- author
- Fawad, Ayesha LU
- supervisor
-
- Olle Melander LU
- Louise Bennet LU
- Peter M Nilsson LU
- opponent
-
- Associate Professor Dalen, Håvard, Trondheim, Norway
- organization
- publishing date
- 2022
- type
- Thesis
- publication status
- published
- subject
- keywords
- Medicine and Health Sciences, Cardiometabolic disease, Obesity : complications, Diabetes, type 2, Proneurotensin, Dyslipidemia
- in
- Lund University, Faculty of Medicine Doctoral Dissertation Series
- issue
- 2022:72
- pages
- 90 pages
- publisher
- Lund University, Faculty of Medicine
- defense location
- Medelhavet, Inga Marie Nilssons gata 53, ingång 46, Skånes Universitetssjukhus i Malmö. Join by Zoom: https://lu-se.zoom.us/j/69291033711
- defense date
- 2022-05-12 09:00:00
- ISSN
- 1652-8220
- ISBN
- 978-91-8021-233-5
- language
- English
- LU publication?
- yes
- id
- e5bcd83a-1f3f-4a32-a1a0-c1fd588e4bbb
- date added to LUP
- 2022-04-15 10:38:25
- date last changed
- 2022-05-03 13:55:41
@phdthesis{e5bcd83a-1f3f-4a32-a1a0-c1fd588e4bbb, abstract = {{The burden of cardiometabolic diseases is increasing worldwide. Early detection of high-risk individuals is essential for appropriate diagnosis, better treatment outcomes, quality of life and lower health related costs. Aims: The overall aim of this thesis is to investigate the possible associations between plasma proneurotensin (Pro-NT) and risk of cardiovascular disease (CVD), type 2 diabetes (T2D), impaired glucose regulation, as well as diet-induced obesity in different study populations. As Pro-NT appears to be a novel risk marker for cardiometabolic morbidity and mortality, we also wanted to study the effects of dietary fat intake on circulating plasma Pro-NT and triglyceride levels. This thesis is based on epidemiological data from three population-based cohorts, The Malmö Preventive Project (MPP), The Malmö Diet and Cancer study- Cardiovascular Cohort (MDC-CC) and The MEDIM cohort (impact of Migration and Ethnicity on Diabetes in Malmö). Paper I, in this cohort including an elderly population, we identified that Pro-NT predicts incident CVD in both genders, but incident T2D in women only, after 5.4 years of follow up. Paper II, in a population based cohort of Iraqi and Swedish born men and women, higher Pro-NT levels were observed both in the Iraqi- vs Swedish-born group. However, elevated plasma Pro-NT was associated with impaired glucose regulations assessed as insulin secretion and action and HbA1c in the Iraqi-population only. Paper III, we found prompt increases in plasma Pro-NT every hour for four hours, after an oral lipid load in healthy individuals. Post-lipid rise of circulating plasma Pro-NT correlated with the changes in plasma triglyceride levels, irrespective of cream and olive oil. Paper IV, in this longitudinal study, we identified that high Pro-NT levels predicted all-cause mortality (ACM) and cause- specific mortalities (CSM) due to CVD, gastrointestinaltract (GIT) diseases, mental and behavioral diseases, and diseases of unspecific causes, in both gender. Conclusion: This thesis shows that circulating Pro-NT is a biomarker that in an elderly population predicts CVD in both gender, but T2D in women only . Irrespective of gender, Pro-NT predicts ACM and CSM. Pro-NT is more strongly associated with impaired glucose regulation in a Middle Eastern immigrant population and may partly explain the increased T2D in this group. Furthermore, oral lipid intake increases Pro-NT levels, which facilitates triglyceride increase in blood in healthy individuals, supporting intestinal lipid absorption as being one key action of Pro-NT.}}, author = {{Fawad, Ayesha}}, isbn = {{978-91-8021-233-5}}, issn = {{1652-8220}}, keywords = {{Medicine and Health Sciences; Cardiometabolic disease; Obesity : complications; Diabetes, type 2; Proneurotensin; Dyslipidemia}}, language = {{eng}}, number = {{2022:72}}, publisher = {{Lund University, Faculty of Medicine}}, school = {{Lund University}}, series = {{Lund University, Faculty of Medicine Doctoral Dissertation Series}}, title = {{Role of Proneurotensin in Cardiometabolic Diseases}}, url = {{https://lup.lub.lu.se/search/files/116796480/Ayesha_LUCRIS_Dissertation_pdf..pdf}}, year = {{2022}}, }