Diet-wide association study of 92 foods and nutrients and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study
(2022) In International Journal of Cancer 151(11). p.1935-1946- Abstract
It is unclear whether diet, and in particular certain foods or nutrients, are associated with lung cancer risk. We assessed associations of 92 dietary factors with lung cancer risk in 327 790 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox regression yielded adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) per SD higher intake/day of each food/nutrient. Correction for multiple comparisons was performed using the false discovery rate and identified associations were evaluated in the Netherlands Cohort Study (NLCS). In EPIC, 2420 incident lung cancer cases were identified during a median of 15 years of follow-up. Higher intakes of fibre (HR per 1 SD higher intake/day = 0.91, 95%... (More)
It is unclear whether diet, and in particular certain foods or nutrients, are associated with lung cancer risk. We assessed associations of 92 dietary factors with lung cancer risk in 327 790 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox regression yielded adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) per SD higher intake/day of each food/nutrient. Correction for multiple comparisons was performed using the false discovery rate and identified associations were evaluated in the Netherlands Cohort Study (NLCS). In EPIC, 2420 incident lung cancer cases were identified during a median of 15 years of follow-up. Higher intakes of fibre (HR per 1 SD higher intake/day = 0.91, 95% CI 0.87-0.96), fruit (HR = 0.91, 95% CI 0.86-0.96) and vitamin C (HR = 0.91, 95% CI 0.86-0.96) were associated with a lower risk of lung cancer, whereas offal (HR = 1.08, 95% CI 1.03-1.14), retinol (HR = 1.06, 95% CI 1.03-1.10) and beer/cider (HR = 1.04, 95% CI 1.02-1.07) intakes were positively associated with lung cancer risk. Associations did not differ by sex and there was less evidence for associations among never smokers. None of the six associations with overall lung cancer risk identified in EPIC were replicated in the NLCS (2861 cases), however in analyses of histological subtypes, inverse associations of fruit and vitamin C with squamous cell carcinoma were replicated in the NLCS. Overall, there is little evidence that intakes of specific foods and nutrients play a major role in primary lung cancer risk, but fruit and vitamin C intakes seem to be inversely associated with squamous cell lung cancer.
(Less)
- author
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cohort study, diet, foods, lung cancer, nutrients
- in
- International Journal of Cancer
- volume
- 151
- issue
- 11
- pages
- 1935 - 1946
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85135518424
- pmid:35830197
- ISSN
- 0020-7136
- DOI
- 10.1002/ijc.34211
- language
- English
- LU publication?
- yes
- id
- fb1933db-44c4-400b-8544-a5fe869c8b5f
- date added to LUP
- 2022-10-20 15:33:13
- date last changed
- 2024-06-13 20:15:01
@article{fb1933db-44c4-400b-8544-a5fe869c8b5f,
abstract = {{<p>It is unclear whether diet, and in particular certain foods or nutrients, are associated with lung cancer risk. We assessed associations of 92 dietary factors with lung cancer risk in 327 790 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox regression yielded adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) per SD higher intake/day of each food/nutrient. Correction for multiple comparisons was performed using the false discovery rate and identified associations were evaluated in the Netherlands Cohort Study (NLCS). In EPIC, 2420 incident lung cancer cases were identified during a median of 15 years of follow-up. Higher intakes of fibre (HR per 1 SD higher intake/day = 0.91, 95% CI 0.87-0.96), fruit (HR = 0.91, 95% CI 0.86-0.96) and vitamin C (HR = 0.91, 95% CI 0.86-0.96) were associated with a lower risk of lung cancer, whereas offal (HR = 1.08, 95% CI 1.03-1.14), retinol (HR = 1.06, 95% CI 1.03-1.10) and beer/cider (HR = 1.04, 95% CI 1.02-1.07) intakes were positively associated with lung cancer risk. Associations did not differ by sex and there was less evidence for associations among never smokers. None of the six associations with overall lung cancer risk identified in EPIC were replicated in the NLCS (2861 cases), however in analyses of histological subtypes, inverse associations of fruit and vitamin C with squamous cell carcinoma were replicated in the NLCS. Overall, there is little evidence that intakes of specific foods and nutrients play a major role in primary lung cancer risk, but fruit and vitamin C intakes seem to be inversely associated with squamous cell lung cancer.</p>}},
author = {{Heath, Alicia K. and Muller, David C. and van den Brandt, Piet A. and Critselis, Elena and Gunter, Marc and Vineis, Paolo and Weiderpass, Elisabete and Boeing, Heiner and Ferrari, Pietro and Merritt, Melissa A. and Rostgaard-Hansen, Agnetha L. and Tjønneland, Anne and Overvad, Kim and Katzke, Verena and Srour, Bernard and Masala, Giovanna and Sacerdote, Carlotta and Ricceri, Fulvio and Pasanisi, Fabrizio and Bueno-de-Mesquita, Bas and Downward, George S. and Skeie, Guri and Sandanger, Torkjel M. and Crous-Bou, Marta and Rodríguez-Barranco, Miguel and Amiano, Pilar and Huerta, José María and Ardanaz, Eva and Drake, Isabel and Johansson, Mikael and Johansson, Ingegerd and Key, Tim and Papadimitriou, Nikos and Riboli, Elio and Tzoulaki, Ioanna and Tsilidis, Konstantinos K.}},
issn = {{0020-7136}},
keywords = {{cohort study; diet; foods; lung cancer; nutrients}},
language = {{eng}},
number = {{11}},
pages = {{1935--1946}},
publisher = {{John Wiley & Sons Inc.}},
series = {{International Journal of Cancer}},
title = {{Diet-wide association study of 92 foods and nutrients and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study}},
url = {{http://dx.doi.org/10.1002/ijc.34211}},
doi = {{10.1002/ijc.34211}},
volume = {{151}},
year = {{2022}},
}