A 76-year-old man with cognitive and neurological symptoms
(2009) In Brain Pathology 19(4). p.4-731- Abstract
A 76-year-old man presented with cognitive symptoms, followed by headache and weakness of the lower limbs and left arm. The clinical course was progressive but fluctuating. On magnetic resonance imaging (MRI), a contrast-enhancing lesion 1 cm in diameter was seen in the left temporal lobe. This lesion became attenuated and a new contrast-enhancing lesion 1 x 2 cm was seen in the left frontal lobe on a subsequent MRI. Following additional tests, treatment with corticosteroids for presumptive neurosarcoidosis was started, however, he soon expired. At autopsy, there was a tumor-like mass in the left frontal lobe. Pathologic evaluation revealed a primary T-cell lymphoma of the central nervous system (CNS). CNS T-cell lymphomas may be... (More)
A 76-year-old man presented with cognitive symptoms, followed by headache and weakness of the lower limbs and left arm. The clinical course was progressive but fluctuating. On magnetic resonance imaging (MRI), a contrast-enhancing lesion 1 cm in diameter was seen in the left temporal lobe. This lesion became attenuated and a new contrast-enhancing lesion 1 x 2 cm was seen in the left frontal lobe on a subsequent MRI. Following additional tests, treatment with corticosteroids for presumptive neurosarcoidosis was started, however, he soon expired. At autopsy, there was a tumor-like mass in the left frontal lobe. Pathologic evaluation revealed a primary T-cell lymphoma of the central nervous system (CNS). CNS T-cell lymphomas may be difficult to diagnose, even histologically, due to their frequent small cell morphology and lack of significant atypia.
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- author
- Brunnström, Hans LU ; Dictor, Michael LU ; Nilsson, Christer LU ; Gülich, Dag and Englund, Elisabet LU
- organization
- publishing date
- 2009-10
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aged, Aphasia, Brain Neoplasms, Fatal Outcome, Frontal Lobe, Humans, Immunohistochemistry, Lymphoma, T-Cell, Magnetic Resonance Imaging, Male, Memory Disorders, Staining and Labeling, Case Reports, Letter
- in
- Brain Pathology
- volume
- 19
- issue
- 4
- pages
- 4 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:19744045
- scopus:69949150255
- ISSN
- 1750-3639
- DOI
- 10.1111/j.1750-3639.2009.00311.x
- language
- English
- LU publication?
- yes
- id
- fb7b3a91-34c6-4e96-bf97-d54a50dd4275
- date added to LUP
- 2017-07-13 09:52:44
- date last changed
- 2024-08-05 00:56:51
@article{fb7b3a91-34c6-4e96-bf97-d54a50dd4275, abstract = {{<p>A 76-year-old man presented with cognitive symptoms, followed by headache and weakness of the lower limbs and left arm. The clinical course was progressive but fluctuating. On magnetic resonance imaging (MRI), a contrast-enhancing lesion 1 cm in diameter was seen in the left temporal lobe. This lesion became attenuated and a new contrast-enhancing lesion 1 x 2 cm was seen in the left frontal lobe on a subsequent MRI. Following additional tests, treatment with corticosteroids for presumptive neurosarcoidosis was started, however, he soon expired. At autopsy, there was a tumor-like mass in the left frontal lobe. Pathologic evaluation revealed a primary T-cell lymphoma of the central nervous system (CNS). CNS T-cell lymphomas may be difficult to diagnose, even histologically, due to their frequent small cell morphology and lack of significant atypia.</p>}}, author = {{Brunnström, Hans and Dictor, Michael and Nilsson, Christer and Gülich, Dag and Englund, Elisabet}}, issn = {{1750-3639}}, keywords = {{Aged; Aphasia; Brain Neoplasms; Fatal Outcome; Frontal Lobe; Humans; Immunohistochemistry; Lymphoma, T-Cell; Magnetic Resonance Imaging; Male; Memory Disorders; Staining and Labeling; Case Reports; Letter}}, language = {{eng}}, number = {{4}}, pages = {{4--731}}, publisher = {{Wiley-Blackwell}}, series = {{Brain Pathology}}, title = {{A 76-year-old man with cognitive and neurological symptoms}}, url = {{http://dx.doi.org/10.1111/j.1750-3639.2009.00311.x}}, doi = {{10.1111/j.1750-3639.2009.00311.x}}, volume = {{19}}, year = {{2009}}, }