Suicidal ideation in a European Huntington's disease population
(2013) In Journal of Affective Disorders 151(1). p.58-248- Abstract
BACKGROUND: Previous studies indicate increased prevalences of suicidal ideation, suicide attempts, and completed suicide in Huntington's disease (HD) compared with the general population. This study investigates correlates and predictors of suicidal ideation in HD.
METHODS: The study cohort consisted of 2106 HD mutation carriers, all participating in the REGISTRY study of the European Huntington's Disease Network. Of the 1937 participants without suicidal ideation at baseline, 945 had one or more follow-up measurements. Participants were assessed for suicidal ideation by the behavioural subscale of the Unified Huntington's Disease Rating Scale (UHDRS). Correlates of suicidal ideation were analyzed using logistic regression... (More)
BACKGROUND: Previous studies indicate increased prevalences of suicidal ideation, suicide attempts, and completed suicide in Huntington's disease (HD) compared with the general population. This study investigates correlates and predictors of suicidal ideation in HD.
METHODS: The study cohort consisted of 2106 HD mutation carriers, all participating in the REGISTRY study of the European Huntington's Disease Network. Of the 1937 participants without suicidal ideation at baseline, 945 had one or more follow-up measurements. Participants were assessed for suicidal ideation by the behavioural subscale of the Unified Huntington's Disease Rating Scale (UHDRS). Correlates of suicidal ideation were analyzed using logistic regression analysis and predictors were analyzed using Cox regression analysis.
RESULTS: At baseline, 169 (8.0%) mutation carriers endorsed suicidal ideation. Disease duration (odds ratio [OR]=0.96; 95% confidence interval [CI]: 0.9-1.0), anxiety (OR=2.14; 95%CI: 1.4-3.3), aggression (OR=2.41; 95%CI: 1.5-3.8), a previous suicide attempt (OR=3.95; 95%CI: 2.4-6.6), and a depressed mood (OR=13.71; 95%CI: 6.7-28.0) were independently correlated to suicidal ideation at baseline. The 4-year cumulative incidence of suicidal ideation was 9.9%. Longitudinally, the presence of a depressed mood (hazard ratio [HR]=2.05; 95%CI: 1.1-4.0) and use of benzodiazepines (HR=2.44; 95%CI: 1.2-5.0) at baseline were independent predictors of incident suicidal ideation, whereas a previous suicide attempt was not predictive.
LIMITATIONS: As suicidal ideation was assessed by only one item, and participants were a selection of all HD mutation carriers, the prevalence of suicidal ideation was likely underestimated.
CONCLUSIONS: Suicidal ideation in HD frequently occurs. Assessment of suicidal ideation is a priority in mutation carriers with a depressed mood and in those using benzodiazepines.
(Less)
- author
- author collaboration
- organization
- publishing date
- 2013-10
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Depression, Europe, Female, Heterozygote, Humans, Huntington Disease, Male, Middle Aged, Prevalence, Proportional Hazards Models, Psychiatric Status Rating Scales, Psychological Tests, Suicidal Ideation, Suicide, Attempted
- in
- Journal of Affective Disorders
- volume
- 151
- issue
- 1
- pages
- 11 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:84888645373
- pmid:23876196
- ISSN
- 1573-2517
- DOI
- 10.1016/j.jad.2013.06.001
- language
- English
- LU publication?
- yes
- additional info
- Part of group-author: Lund (Lund University and Skåne University Hospital, dept neurology): Åsa Petersén; Jan Reimer; Håkan Widner.
- id
- fce5a45a-a4a9-4d30-9902-3c18f2661108
- date added to LUP
- 2017-04-19 18:32:41
- date last changed
- 2024-07-21 19:31:56
@article{fce5a45a-a4a9-4d30-9902-3c18f2661108, abstract = {{<p>BACKGROUND: Previous studies indicate increased prevalences of suicidal ideation, suicide attempts, and completed suicide in Huntington's disease (HD) compared with the general population. This study investigates correlates and predictors of suicidal ideation in HD.</p><p>METHODS: The study cohort consisted of 2106 HD mutation carriers, all participating in the REGISTRY study of the European Huntington's Disease Network. Of the 1937 participants without suicidal ideation at baseline, 945 had one or more follow-up measurements. Participants were assessed for suicidal ideation by the behavioural subscale of the Unified Huntington's Disease Rating Scale (UHDRS). Correlates of suicidal ideation were analyzed using logistic regression analysis and predictors were analyzed using Cox regression analysis.</p><p>RESULTS: At baseline, 169 (8.0%) mutation carriers endorsed suicidal ideation. Disease duration (odds ratio [OR]=0.96; 95% confidence interval [CI]: 0.9-1.0), anxiety (OR=2.14; 95%CI: 1.4-3.3), aggression (OR=2.41; 95%CI: 1.5-3.8), a previous suicide attempt (OR=3.95; 95%CI: 2.4-6.6), and a depressed mood (OR=13.71; 95%CI: 6.7-28.0) were independently correlated to suicidal ideation at baseline. The 4-year cumulative incidence of suicidal ideation was 9.9%. Longitudinally, the presence of a depressed mood (hazard ratio [HR]=2.05; 95%CI: 1.1-4.0) and use of benzodiazepines (HR=2.44; 95%CI: 1.2-5.0) at baseline were independent predictors of incident suicidal ideation, whereas a previous suicide attempt was not predictive.</p><p>LIMITATIONS: As suicidal ideation was assessed by only one item, and participants were a selection of all HD mutation carriers, the prevalence of suicidal ideation was likely underestimated.</p><p>CONCLUSIONS: Suicidal ideation in HD frequently occurs. Assessment of suicidal ideation is a priority in mutation carriers with a depressed mood and in those using benzodiazepines.</p>}}, author = {{Hubers, Anna A M and van Duijn, Erik and Roos, Raymund A C and Craufurd, David and Rickards, Hugh and Bernhard Landwehrmeyer, G and van der Mast, Rose C and Giltay, Erik J and Petersén, Åsa and Reimer, Jan and Widner, Håkan}}, issn = {{1573-2517}}, keywords = {{Depression; Europe; Female; Heterozygote; Humans; Huntington Disease; Male; Middle Aged; Prevalence; Proportional Hazards Models; Psychiatric Status Rating Scales; Psychological Tests; Suicidal Ideation; Suicide, Attempted}}, language = {{eng}}, number = {{1}}, pages = {{58--248}}, publisher = {{Elsevier}}, series = {{Journal of Affective Disorders}}, title = {{Suicidal ideation in a European Huntington's disease population}}, url = {{http://dx.doi.org/10.1016/j.jad.2013.06.001}}, doi = {{10.1016/j.jad.2013.06.001}}, volume = {{151}}, year = {{2013}}, }