Hakon Leffler

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2024
Mark The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis
Comeglio, Paolo ; Guarnieri, Giulia ; Filippi, Sandra ; Cellai, Ilaria ; Acciai, Gabriele ; Holyer, Ian ; Zetterberg, Fredrik ; Leffler, Hakon ^LU ; Kahl-Knutson, Barbro ^LU and Sarchielli, Erica , et al. (2024) In Frontiers in Pharmacology 15.
- Contribution to journal › Article
Mark Exploration into Galectin-3 Driven Endocytosis and Lattices
Shafaq-Zadah, Massiullah ; Dransart, Estelle ; Mani, Satish Kailasam ; Sampaio, Julio Lopes ; Bouidghaghen, Lydia ; Nilsson, Ulf J. ^LU ; Leffler, Hakon ^LU and Johannes, Ludger (2024) In Biomolecules 14(9).
- Contribution to journal › Article
Mark Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer
Zetterberg, Fredrik R. ; Peterson, Kristoffer ; Nilsson, Ulf J. ^LU ; Andréasson Dahlgren, Kajsa ; Diehl, Carl ; Hoyler, Ian ; Håkansson, Maria ; Khabut, Areej ^LU ; Kahl-Knutson, Barbro ^LU and Leffler, Hakon ^LU , et al. (2024) In Journal of Medicinal Chemistry 67(11). p.9374-9388
- Contribution to journal › Article
Mark Interplay of halogen bonding and solvation in protein-ligand binding
Verteramo, Maria Luisa ^LU ; Ignjatović, Majda Misini ; Kumar, Rohit ^LU ; Wernersson, Sven ^LU ; Ekberg, Vilhelm ^LU ; Wallerstein, Johan ^LU ; Carlström, Göran ^LU ; Chadimová, Veronika ; Leffler, Hakon ^LU and Zetterberg, Fredrik , et al. (2024) In iScience 27(4).
- Contribution to journal › Article
Mark Determining the Affinity and Kinetics of Small Molecule Inhibitors of Galectin-1 Using Surface Plasmon Resonance
Kim, Henry ; Kretz, Louis ; Ronin, Céline ; Starck, Christina ; Roper, James A. ; Kahl-Knutson, Barbro ^LU ; Peterson, Kristoffer ^LU ; Leffler, Hakon ^LU ; Nilsson, Ulf J. ^LU and Pedersen, Anders , et al. (2024) In International Journal of Molecular Sciences 25(12).
- Contribution to journal › Article
Mark Myocardin related transcription factor and galectin-3 drives lipid accumulation in human blood vessels
Arévalo-Martinez, Marycarmen ^LU ; Ede, Jacob ^LU ; van der Have, Oscar ^LU ; Ritsvall, Olivia ^LU ; Zetterberg, Fredrik R ; Nilsson, Ulf J ^LU ; Leffler, Hakon ^LU ; Holmberg, Johan ^LU and Albinsson, Sebastian ^LU (2024) In Vascular Pharmacology 156.
- Contribution to journal › Article
Mark Endocytic Roles of Glycans on Proteins and Lipids
Johannes, Ludger ; Shafaq-Zadah, Massiullah ; Dransart, Estelle ; Wunder, Christian and Leffler, Hakon ^LU (2024) In Cold Spring Harbor perspectives in biology 16(1).
- Contribution to journal › Article
2023
Mark Increased synovial galectin-3 induce inflammatory fibroblast activation and osteoclastogenesis in patients with rheumatoid arthritis
Nielsen, M. A. ; Køster, D. ; Greisen, S. ; Troldborg, A. ; Stengaard-Pedersen, K. ; Junker, P. ; Hørslev-Petersen, K. ; Hetland, M. L. ; Østergaard, M. and Hvid, M. , et al. (2023) In Scandinavian Journal of Rheumatology 52(1). p.33-41
- Contribution to journal › Article
Mark Increased Galectin-9 Levels Correlate with Disease Activity in Patients with DMARD-Naïve Rheumatoid Arthritis and Modulate the Secretion of MCP-1 and IL-6 from Synovial Fibroblasts
Nielsen, Morten A. ; Køster, Ditte ; Mehta, Akul Y. ; Stengaard-Pedersen, Kristian ; Busson, Pierre ; Junker, Peter ; Hørslev-Petersen, Kim ; Hetland, Merete Lund ; Østergaard, Mikkel and Hvid, Malene , et al. (2023) In Cells 12(2).
- Contribution to journal › Article
Mark Strong Binding of C-Glycosylic1,2-Thiodisaccharides to Galectin-3─Enthalpy-Driven Affinity Enhancement by Water-Mediated Hydrogen Bonds
Lázár, László ; Tsagkarakou, Anastasia S ; Stravodimos, George ; Kontopidis, George ; Leffler, Hakon ^LU ; Nilsson, Ulf J ^LU ; Somsák, László and Leonidas, Demetres D (2023) In Journal of Medicinal Chemistry 66(17). p.12420-12431
- Contribution to journal › Article

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