Hakon Leffler

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2021
Mark Selective Galectin-8N Ligands : The Design and Synthesis of Phthalazinone-d-Galactals
van Klaveren, Sjors ^LU ; Sundin, Anders P. ^LU ; Jakopin, Žiga ; Anderluh, Marko ^LU ; Leffler, Hakon ^LU ; Nilsson, Ulf J. ^LU and Tomašič, Tihomir (2021) In ChemMedChem 17(6).
- Contribution to journal › Article
Mark Benzimidazole–galactosides bind selectively to the Galectin-8 N-Terminal domain : Structure-based design and optimisation
Hassan, Mujtaba ^LU ; van Klaveren, Sjors ^LU ; Håkansson, Maria ^LU ; Diehl, Carl ^LU ; Kovačič, Rebeka ; Baussière, Floriane ; Sundin, Anders P. ^LU ; Dernovšek, Jaka ; Walse, Björn ^LU and Zetterberg, Fredrik , et al. (2021) In European Journal of Medicinal Chemistry 223.
- Contribution to journal › Article
2020
Mark In Vivo Veritas : ¹⁸F-Radiolabeled Glycomimetics Allow Insights into the Pharmacological Fate of Galectin-3 Inhibitors
Bratteby, Klas ; Torkelsson, Edvard ; L'Estrade, Elina Tampio ; Peterson, Kristoffer ^LU ; Shalgunov, Vladimir ; Xiong, Mengfei ; Leffler, Hakon ^LU ; Zetterberg, Fredrik R. ; Olsson, Tomas G. ^LU and Gillings, Nic , et al. (2020) In Journal of Medicinal Chemistry 63(2). p.747-755
- Contribution to journal › Article
Mark Epimers Switch Galectin-9 Domain Selectivity : 3 N-Aryl Galactosides Bind the C-Terminal and Gulosides Bind the N-Terminal
Mahanti, Mukul ^LU ; Pal, Kumar Bhaskar ; Sundin, Anders P. ^LU ; Leffler, Hakon ^LU and Nilsson, Ulf J. ^LU (2020) In ACS Medicinal Chemistry Letters 11(1). p.34-39
- Contribution to journal › Article
2019
Mark 3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-Sites for High-Affinity and High-Selectivity Inhibition of Galectin-3
Dahlqvist, Alexander ^LU ; Mandal, Santanu ^LU ; Peterson, Kristoffer ^LU ; Håkansson, Maria ^LU ; Logan, Derek T. ^LU ; Zetterberg, Fredrik R. ; Leffler, Hakon ^LU and Nilsson, Ulf J. ^LU (2019) In Molecules 24(24).
- Contribution to journal › Article
Mark Aminopyrimidine-galactose hybrids are highly selective galectin-3 inhibitors
Dahlqvist, Alexander ^LU ; Zetterberg, Fredrik R. ; Leffler, Hakon ^LU and Nilsson, Ulf J. ^LU (2019) In MedChemComm 10(6). p.913-925
- Contribution to journal › Article
Mark A galactoside-binding protein tricked into binding unnatural pyranose derivatives : 3-deoxy-3-methyl-gulosides selectively inhibit galectin-1
Pal, Kumar Bhaskar ; Mahanti, Mukul ^LU ; Leffler, Hakon ^LU and Nilsson, Ulf J. ^LU (2019) In International Journal of Molecular Sciences 20(15).
- Contribution to journal › Article
Mark Stereo- And regioselective hydroboration of 1-exo-methylene pyranoses : Discovery of aryltriazolylmethyl C-galactopyranosides as selective galectin-1 inhibitors
Dahlqvist, Alexander ^LU ; Furevi, Axel ; Warlin, Niklas ^LU ; Leffler, Hakon ^LU and Nilsson, Ulf J. ^LU (2019) In Beilstein Journal of Organic Chemistry 15. p.1046-1060
- Contribution to journal › Article
Mark Structure and Energetics of Ligand–Fluorine Interactions with Galectin-3 Backbone and Side-Chain Amides : Insight into Solvation Effects and Multipolar Interactions
Kumar, Rohit ^LU ; Ignjatović, Majda Misini ^LU ; Peterson, Kristoffer ^LU ; Olsson, Martin ^LU ; Leffler, Hakon ^LU ; Ryde, Ulf ^LU ; Nilsson, Ulf J. ^LU and Logan, Derek T. ^LU (2019) In ChemMedChem 14(16). p.1528-1536
- Contribution to journal › Article
Mark Human trophoblast requires galectin-3 for cell migration and invasion
Bojić-Trbojević ; Jovanović Krivokuća, M. ; Vilotić, A. ; Kolundžić, N. ; Stefanoska, I. ; Zetterberg, F. ; Nilsson, U. J. ^LU ; Leffler, H. ^LU and Vićovac, Lj (2019) In Scientific Reports 9(1).
- Contribution to journal › Article

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