Deniz Kirik
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- 2004
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Mark
Dissociation between short-term increased graft survival and long-term functional improvements in Parkinsonian rats overexpressing glial cell line-derived neurotrophic factor.
(
- Contribution to journal › Article
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Mark
Regulated delivery of glial cell line-derived neurotrophic factor into rat striatum, using a tetracycline-dependent lentiviral vector.
(
- Contribution to journal › Article
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Mark
Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system.
(
- Contribution to journal › Article
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Mark
Localized striatal delivery of GDNF as a treatment for Parkinson disease.
(
- Contribution to journal › Article
- 2003
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Mark
Recombinant adeno-associated viral vector (rAAV) delivery of GDNF provides protection against 6-OHDA lesion in the common marmoset monkey (Callithrix jacchus)
(
- Contribution to journal › Article
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Mark
Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke.
(
- Contribution to journal › Article
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Mark
Elevated GDNF levels following viral vector-mediated gene transfer can increase neuronal death after stroke in rats.
(
- Contribution to journal › Article
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Mark
Long-term striatal overexpression of GDNF selectively downregulates tyrosine hydroxylase in the intact nigrostriatal dopamine system.
(
- Contribution to journal › Article
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Mark
Nigrostriatal {alpha}-synucleinopathy induced by viral vector-mediated overexpression of human {alpha}-synuclein: A new primate model of Parkinson's disease.
(
- Contribution to journal › Article
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Mark
Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectors.
(
- Contribution to journal › Scientific review
- 2002
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Mark
L-DOPA-Induced Dyskinesia in the Intrastriatal 6-Hydroxydopamine Model of Parkinson's Disease: Relation to Motor and Cellular Parameters of Nigrostriatal Function.
(
- Contribution to journal › Article
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Mark
Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer.
(
- Contribution to journal › Article
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Mark
Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's disease.
(
- Contribution to journal › Article
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Mark
Neuroprotection in the rat Parkinson model by intrastriatal GDNF gene transfer using a lentiviral vector.
(
- Contribution to journal › Article
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Mark
Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer.
(
- Contribution to journal › Article
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Mark
Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system
(
- Contribution to journal › Article
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Mark
Neuronal replacement from endogenous precursors in the adult brain after stroke.
(
- Contribution to journal › Article
- 2001
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Mark
Delayed infusion of GDNF promotes recovery of motor function in the partial lesion model of Parkinson's disease
(
- Contribution to journal › Article
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Mark
Growth and functional efficacy of intrastriatal nigral transplants depend on the extent of nigrostriatal degeneration
2001) In The Journal of Neuroscience : the official journal of the Society for Neuroscience 21(8). p.2889-2896(
- Contribution to journal › Article
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Mark
Restorative and neuroprotective treatment strategies for Parkinson’s disease: tudies on fetal dopamine cell transplants and GDNF delivery by intracerebral injections and recombinant AAV vectors.
2001)(
- Thesis › Doctoral thesis (compilation)