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Ghrelin is a regulator of glucagon-like peptide 1 secretion and transcription in mice

Lindqvist, Andreas LU ; Shcherbina, Liliya LU ; Thorén Fischer, Ann-Helen LU and Wierup, Nils LU (2017) In Frontiers in Endocrinology 8(JUN).
Abstract

The gut hormones ghrelin, glucagon-like peptide 1 (GLP-1), and glucose-dependent insulinotropic peptide (GIP) have been intensively studied for their role in metabolism. It is, however, not well known whether the hormones interplay and regulate the secretion of each other. In this study, we studied the effect of ghrelin on GLP-1, GIP, and insulin secretion during an oral glucose tolerance test (OGTT) in mice. Intravenous administration of ghrelin caused increased GLP-1 secretion during the OGTT. On the other hand, ghrelin had no effect on circulating levels of glucose, insulin, and GIP. Furthermore, ghrelin treatment reduced proglucagon mRNA expression in GLUTag cells. The effect of ghrelin on GLP-1 secretion and proglucagon... (More)

The gut hormones ghrelin, glucagon-like peptide 1 (GLP-1), and glucose-dependent insulinotropic peptide (GIP) have been intensively studied for their role in metabolism. It is, however, not well known whether the hormones interplay and regulate the secretion of each other. In this study, we studied the effect of ghrelin on GLP-1, GIP, and insulin secretion during an oral glucose tolerance test (OGTT) in mice. Intravenous administration of ghrelin caused increased GLP-1 secretion during the OGTT. On the other hand, ghrelin had no effect on circulating levels of glucose, insulin, and GIP. Furthermore, ghrelin treatment reduced proglucagon mRNA expression in GLUTag cells. The effect of ghrelin on GLP-1 secretion and proglucagon transcription was reinforced by the presence of GHS-R1a in human and mouse ileal L-cells, as well as in GLUTag cells. In summary, ghrelin is a regulator of GLP-1 secretion and transcription, and interfering with GHS-R1a signaling may be a way forward to enhance endogenous GLP-1 secretion in subjects with type 2 diabetes.

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organization
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type
Contribution to journal
publication status
published
subject
keywords
Ghrelin, GHS-R1a, Glucagon-like peptide 1, GLUTag cells, Oral glucose tolerance test
in
Frontiers in Endocrinology
volume
8
issue
JUN
publisher
Frontiers
external identifiers
  • scopus:85021220694
  • wos:000403541800002
ISSN
1664-2392
DOI
10.3389/fendo.2017.00135
language
English
LU publication?
yes
id
01d5bd84-4548-4ef9-a0a6-74f5031a0b86
date added to LUP
2017-08-11 13:55:23
date last changed
2017-09-18 11:41:28
@article{01d5bd84-4548-4ef9-a0a6-74f5031a0b86,
  abstract     = {<p>The gut hormones ghrelin, glucagon-like peptide 1 (GLP-1), and glucose-dependent insulinotropic peptide (GIP) have been intensively studied for their role in metabolism. It is, however, not well known whether the hormones interplay and regulate the secretion of each other. In this study, we studied the effect of ghrelin on GLP-1, GIP, and insulin secretion during an oral glucose tolerance test (OGTT) in mice. Intravenous administration of ghrelin caused increased GLP-1 secretion during the OGTT. On the other hand, ghrelin had no effect on circulating levels of glucose, insulin, and GIP. Furthermore, ghrelin treatment reduced proglucagon mRNA expression in GLUTag cells. The effect of ghrelin on GLP-1 secretion and proglucagon transcription was reinforced by the presence of GHS-R1a in human and mouse ileal L-cells, as well as in GLUTag cells. In summary, ghrelin is a regulator of GLP-1 secretion and transcription, and interfering with GHS-R1a signaling may be a way forward to enhance endogenous GLP-1 secretion in subjects with type 2 diabetes.</p>},
  articleno    = {135},
  author       = {Lindqvist, Andreas and Shcherbina, Liliya and Thorén Fischer, Ann-Helen and Wierup, Nils},
  issn         = {1664-2392},
  keyword      = {Ghrelin,GHS-R1a,Glucagon-like peptide 1,GLUTag cells,Oral glucose tolerance test},
  language     = {eng},
  month        = {06},
  number       = {JUN},
  publisher    = {Frontiers},
  series       = {Frontiers in Endocrinology},
  title        = {Ghrelin is a regulator of glucagon-like peptide 1 secretion and transcription in mice},
  url          = {http://dx.doi.org/10.3389/fendo.2017.00135},
  volume       = {8},
  year         = {2017},
}