Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease
(1990) In Science (New York, N.Y.) 247(4942). p.7-574- Abstract
Neural transplantation can restore striatal dopaminergic neurotransmission in animal models of Parkinson's disease. It has now been shown that mesencephalic dopamine neurons, obtained from human fetuses of 8 to 9 weeks gestational age, can survive in the human brain and produce marked and sustained symptomatic relief in a patient severely affected with idiopathic Parkinson's disease. The grafts, which were implanted unilaterally into the putamen by stereotactic surgery, restored dopamine synthesis and storage in the grafted area, as assessed by positron emission tomography with 6-L-[18F]fluorodopa. This neurochemical change was accompanied by a therapeutically significant reduction in the patient's severe rigidity and bradykinesia and a... (More)
Neural transplantation can restore striatal dopaminergic neurotransmission in animal models of Parkinson's disease. It has now been shown that mesencephalic dopamine neurons, obtained from human fetuses of 8 to 9 weeks gestational age, can survive in the human brain and produce marked and sustained symptomatic relief in a patient severely affected with idiopathic Parkinson's disease. The grafts, which were implanted unilaterally into the putamen by stereotactic surgery, restored dopamine synthesis and storage in the grafted area, as assessed by positron emission tomography with 6-L-[18F]fluorodopa. This neurochemical change was accompanied by a therapeutically significant reduction in the patient's severe rigidity and bradykinesia and a marked diminuation of the fluctuations in the patient's condition during optimum medication (the "on-off" phenomenon). The clinical improvement was most marked on the side contralateral to the transplant.
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- author
- Lindvall, O LU ; Brundin, Patrik LU ; Widner, H LU ; Rehncrona, S LU ; Gustavii, Björn LU ; Frackowiak, R S ; Leenders, K L ; Sawle, G V ; Rothwell, J C and Marsden, C D
- organization
- publishing date
- 1990-02-02
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Brain, Cell Survival, Dihydroxyphenylalanine, Dopamine, Fetus, Fluorine Radioisotopes, Follow-Up Studies, Humans, Immunosuppression, Mesencephalon, Neurons, Parkinson Disease, Putamen, Tomography, Emission-Computed, Journal Article, Research Support, Non-U.S. Gov't
- in
- Science (New York, N.Y.)
- volume
- 247
- issue
- 4942
- pages
- 7 - 574
- publisher
- American Association for the Advancement of Science (AAAS)
- external identifiers
-
- pmid:2105529
- scopus:0025058215
- ISSN
- 0036-8075
- DOI
- 10.1126/science.2105529
- language
- English
- LU publication?
- yes
- id
- 033aec9d-9a88-4807-becb-8a68b910a41f
- date added to LUP
- 2017-04-19 18:35:43
- date last changed
- 2024-06-10 17:36:10
@article{033aec9d-9a88-4807-becb-8a68b910a41f,
abstract = {{<p>Neural transplantation can restore striatal dopaminergic neurotransmission in animal models of Parkinson's disease. It has now been shown that mesencephalic dopamine neurons, obtained from human fetuses of 8 to 9 weeks gestational age, can survive in the human brain and produce marked and sustained symptomatic relief in a patient severely affected with idiopathic Parkinson's disease. The grafts, which were implanted unilaterally into the putamen by stereotactic surgery, restored dopamine synthesis and storage in the grafted area, as assessed by positron emission tomography with 6-L-[18F]fluorodopa. This neurochemical change was accompanied by a therapeutically significant reduction in the patient's severe rigidity and bradykinesia and a marked diminuation of the fluctuations in the patient's condition during optimum medication (the "on-off" phenomenon). The clinical improvement was most marked on the side contralateral to the transplant.</p>}},
author = {{Lindvall, O and Brundin, Patrik and Widner, H and Rehncrona, S and Gustavii, Björn and Frackowiak, R S and Leenders, K L and Sawle, G V and Rothwell, J C and Marsden, C D}},
issn = {{0036-8075}},
keywords = {{Brain; Cell Survival; Dihydroxyphenylalanine; Dopamine; Fetus; Fluorine Radioisotopes; Follow-Up Studies; Humans; Immunosuppression; Mesencephalon; Neurons; Parkinson Disease; Putamen; Tomography, Emission-Computed; Journal Article; Research Support, Non-U.S. Gov't}},
language = {{eng}},
month = {{02}},
number = {{4942}},
pages = {{7--574}},
publisher = {{American Association for the Advancement of Science (AAAS)}},
series = {{Science (New York, N.Y.)}},
title = {{Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease}},
url = {{http://dx.doi.org/10.1126/science.2105529}},
doi = {{10.1126/science.2105529}},
volume = {{247}},
year = {{1990}},
}