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Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease

Lindvall, O LU ; Brundin, Patrik LU ; Widner, H LU ; Rehncrona, S LU ; Gustavii, Björn LU ; Frackowiak, R S; Leenders, K L; Sawle, G V; Rothwell, J C and Marsden, C D (1990) In Science (New York, N.Y.) 247(4942). p.7-574
Abstract

Neural transplantation can restore striatal dopaminergic neurotransmission in animal models of Parkinson's disease. It has now been shown that mesencephalic dopamine neurons, obtained from human fetuses of 8 to 9 weeks gestational age, can survive in the human brain and produce marked and sustained symptomatic relief in a patient severely affected with idiopathic Parkinson's disease. The grafts, which were implanted unilaterally into the putamen by stereotactic surgery, restored dopamine synthesis and storage in the grafted area, as assessed by positron emission tomography with 6-L-[18F]fluorodopa. This neurochemical change was accompanied by a therapeutically significant reduction in the patient's severe rigidity and bradykinesia and a... (More)

Neural transplantation can restore striatal dopaminergic neurotransmission in animal models of Parkinson's disease. It has now been shown that mesencephalic dopamine neurons, obtained from human fetuses of 8 to 9 weeks gestational age, can survive in the human brain and produce marked and sustained symptomatic relief in a patient severely affected with idiopathic Parkinson's disease. The grafts, which were implanted unilaterally into the putamen by stereotactic surgery, restored dopamine synthesis and storage in the grafted area, as assessed by positron emission tomography with 6-L-[18F]fluorodopa. This neurochemical change was accompanied by a therapeutically significant reduction in the patient's severe rigidity and bradykinesia and a marked diminuation of the fluctuations in the patient's condition during optimum medication (the "on-off" phenomenon). The clinical improvement was most marked on the side contralateral to the transplant.

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organization
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Contribution to journal
publication status
published
subject
keywords
Brain, Cell Survival, Dihydroxyphenylalanine, Dopamine, Fetus, Fluorine Radioisotopes, Follow-Up Studies, Humans, Immunosuppression, Mesencephalon, Neurons, Parkinson Disease, Putamen, Tomography, Emission-Computed, Journal Article, Research Support, Non-U.S. Gov't
in
Science (New York, N.Y.)
volume
247
issue
4942
pages
7 - 574
publisher
The American Association for the Advancement of Science
external identifiers
  • scopus:0025058215
ISSN
0036-8075
DOI
10.1126/science.2105529
language
English
LU publication?
yes
id
033aec9d-9a88-4807-becb-8a68b910a41f
date added to LUP
2017-04-19 18:35:43
date last changed
2017-10-15 04:49:17
@article{033aec9d-9a88-4807-becb-8a68b910a41f,
  abstract     = {<p>Neural transplantation can restore striatal dopaminergic neurotransmission in animal models of Parkinson's disease. It has now been shown that mesencephalic dopamine neurons, obtained from human fetuses of 8 to 9 weeks gestational age, can survive in the human brain and produce marked and sustained symptomatic relief in a patient severely affected with idiopathic Parkinson's disease. The grafts, which were implanted unilaterally into the putamen by stereotactic surgery, restored dopamine synthesis and storage in the grafted area, as assessed by positron emission tomography with 6-L-[18F]fluorodopa. This neurochemical change was accompanied by a therapeutically significant reduction in the patient's severe rigidity and bradykinesia and a marked diminuation of the fluctuations in the patient's condition during optimum medication (the "on-off" phenomenon). The clinical improvement was most marked on the side contralateral to the transplant.</p>},
  author       = {Lindvall, O and Brundin, Patrik and Widner, H and Rehncrona, S and Gustavii, Björn and Frackowiak, R S and Leenders, K L and Sawle, G V and Rothwell, J C and Marsden, C D},
  issn         = {0036-8075},
  keyword      = {Brain,Cell Survival,Dihydroxyphenylalanine,Dopamine,Fetus,Fluorine Radioisotopes,Follow-Up Studies,Humans,Immunosuppression,Mesencephalon,Neurons,Parkinson Disease,Putamen,Tomography, Emission-Computed,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  month        = {02},
  number       = {4942},
  pages        = {7--574},
  publisher    = {The American Association for the Advancement of Science},
  series       = {Science (New York, N.Y.)},
  title        = {Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease},
  url          = {http://dx.doi.org/10.1126/science.2105529 },
  volume       = {247},
  year         = {1990},
}