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Meat and fish consumption and risk of pancreatic cancer: Results from the European Prospective Investigation into Cancer and Nutrition

Rohrmann, Sabine; Linseisen, Jakob; Nothlings, Ute; Overvad, Kim; Egeberg, Rikke; Tjonneland, Anne; Boutron-Ruault, Marie Christine; Clavel-Chapelon, Francoise; Cottet, Vanessa and Pala, Valeria, et al. (2013) In International Journal of Cancer 132(3). p.617-624
Abstract
Pancreatic cancer is the fourth most common cause of cancer death worldwide with large geographical variation, which implies the contribution of diet and lifestyle in its etiology. We examined the association of meat and fish consumption with risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). A total of 477,202 EPIC participants from 10 European countries recruited between 1992 and 2000 were included in our analysis. Until 2008, 865 nonendocrine pancreatic cancer cases have been observed. Calibrated relative risks (RRs) and 95% confidence intervals (CIs) were computed using multivariable-adjusted Cox hazard regression models. The consumption of red meat (RR per 50 g increase per day =... (More)
Pancreatic cancer is the fourth most common cause of cancer death worldwide with large geographical variation, which implies the contribution of diet and lifestyle in its etiology. We examined the association of meat and fish consumption with risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). A total of 477,202 EPIC participants from 10 European countries recruited between 1992 and 2000 were included in our analysis. Until 2008, 865 nonendocrine pancreatic cancer cases have been observed. Calibrated relative risks (RRs) and 95% confidence intervals (CIs) were computed using multivariable-adjusted Cox hazard regression models. The consumption of red meat (RR per 50 g increase per day = 1.03, 95% CI = 0.931.14) and processed meat (RR per 50 g increase per day = 0.93, 95% CI = 0.711.23) were not associated with an increased pancreatic cancer risk. Poultry consumption tended to be associated with an increased pancreatic cancer risk (RR per 50 g increase per day = 1.72, 95% CI = 1.042.84); however, there was no association with fish consumption (RR per 50 g increase per day = 1.22, 95% CI = 0.921.62). Our results do not support the conclusion of the World Cancer Research Fund that red or processed meat consumption may possibly increase the risk of pancreatic cancer. The positive association of poultry consumption with pancreatic cancer might be a chance finding as it contradicts most previous findings. (Less)
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publication status
published
subject
keywords
meat, fish, pancreatic cancer, cohort, EPIC
in
International Journal of Cancer
volume
132
issue
3
pages
617 - 624
publisher
John Wiley & Sons
external identifiers
  • wos:000311620100019
  • scopus:84870241775
ISSN
0020-7136
DOI
10.1002/ijc.27637
language
English
LU publication?
yes
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0aa98d09-304e-4ae5-91b6-5d664d9c65dd (old id 3401043)
date added to LUP
2013-02-01 07:06:36
date last changed
2019-08-18 03:05:52
@article{0aa98d09-304e-4ae5-91b6-5d664d9c65dd,
  abstract     = {Pancreatic cancer is the fourth most common cause of cancer death worldwide with large geographical variation, which implies the contribution of diet and lifestyle in its etiology. We examined the association of meat and fish consumption with risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). A total of 477,202 EPIC participants from 10 European countries recruited between 1992 and 2000 were included in our analysis. Until 2008, 865 nonendocrine pancreatic cancer cases have been observed. Calibrated relative risks (RRs) and 95% confidence intervals (CIs) were computed using multivariable-adjusted Cox hazard regression models. The consumption of red meat (RR per 50 g increase per day = 1.03, 95% CI = 0.931.14) and processed meat (RR per 50 g increase per day = 0.93, 95% CI = 0.711.23) were not associated with an increased pancreatic cancer risk. Poultry consumption tended to be associated with an increased pancreatic cancer risk (RR per 50 g increase per day = 1.72, 95% CI = 1.042.84); however, there was no association with fish consumption (RR per 50 g increase per day = 1.22, 95% CI = 0.921.62). Our results do not support the conclusion of the World Cancer Research Fund that red or processed meat consumption may possibly increase the risk of pancreatic cancer. The positive association of poultry consumption with pancreatic cancer might be a chance finding as it contradicts most previous findings.},
  author       = {Rohrmann, Sabine and Linseisen, Jakob and Nothlings, Ute and Overvad, Kim and Egeberg, Rikke and Tjonneland, Anne and Boutron-Ruault, Marie Christine and Clavel-Chapelon, Francoise and Cottet, Vanessa and Pala, Valeria and Tumino, Rosario and Palli, Domenico and Panico, Salvatore and Vineis, Paolo and Boeing, Heiner and Pischon, Tobias and Grote, Verena and Teucher, Birigit and Khaw, Kay-Tee and Wareham, Nicholas J. and Crowe, Francesca L. and Goufa, Ioulia and Orfanos, Philippos and Trichopoulou, Antonia and Jeurnink, Suzanne M. and Siersema, Peter D. and Peeters, Petra H. M. and Brustad, Magritt and Engeset, Dagrun and Skeie, Guri and Duell, Eric J. and Amiano, Pilar and Barricarte, Aurelio and Molina-Montes, Esther and Rodriguez, Laudina and Tormo, Maria-Jose and Sund, Malin and Ye, Weimin and Lindkvist, Bjorn and Johansen, Dorthe and Ferrari, Pietro and Jenab, Mazda and Slimani, Nadia and Ward, Heather and Riboli, Elio and Norat, Teresa and Bueno-de-Mesquita, H. Bas},
  issn         = {0020-7136},
  keyword      = {meat,fish,pancreatic cancer,cohort,EPIC},
  language     = {eng},
  number       = {3},
  pages        = {617--624},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Meat and fish consumption and risk of pancreatic cancer: Results from the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1002/ijc.27637},
  volume       = {132},
  year         = {2013},
}