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One-year recovery from breast cancer : Importance of tumor and treatment-related factors, resilience, and sociodemographic factors for health-related quality of life

Veličković, Katarina LU ; Borrebaeck, Carl A.K. LU ; Bendahl, Pär Ola LU ; Hegardt, Cecilia LU ; Johnsson, Per LU ; Richter, Corinna LU ; Rydén, Lisa LU orcid and Hallberg, Ingalill Rahm LU (2022) In Frontiers in Oncology 12.
Abstract

Aim: This study investigated the changes in health-related quality of life from diagnosis to 1 year after diagnosis in breast cancer (BC) patients and the influence of clinical, psychological, and sociodemographic variables. An additional aim was to explore the mediating and moderating effects of resilience on changes in health-related quality of life. Methods: A longitudinal population-based study was conducted in southern Sweden. Newly diagnosed BC patients filled in measures of health-related quality of life, resilience, and sociodemographic variables at diagnosis (N = 980) and 1 year post-diagnosis (N = 780). Clinical variables were extracted from the Swedish national breast cancer quality registry. Mixed-model analyses were... (More)

Aim: This study investigated the changes in health-related quality of life from diagnosis to 1 year after diagnosis in breast cancer (BC) patients and the influence of clinical, psychological, and sociodemographic variables. An additional aim was to explore the mediating and moderating effects of resilience on changes in health-related quality of life. Methods: A longitudinal population-based study was conducted in southern Sweden. Newly diagnosed BC patients filled in measures of health-related quality of life, resilience, and sociodemographic variables at diagnosis (N = 980) and 1 year post-diagnosis (N = 780). Clinical variables were extracted from the Swedish national breast cancer quality registry. Mixed-model analyses were performed. Results: Most health-related quality of life outcomes declined from diagnosis to 1 year post-diagnosis. Role limitations due to emotional problems remained the same, whereas mental health improved. Lower health-related quality of life outcomes were associated with symptomatic detection and axillary dissection. Patients with a higher TNM stage and histologic grade and estrogen receptor (ER)-negative and human epidermal growth factor 2 (HER2)-positive status, who received chemotherapy, antibody therapy, or bisphosphonate therapy, had a steeper decline in outcomes. Changes in resilience were positively associated with all outcomes but did not mediate or moderate changes in any. Resilience at baseline moderated changes in bodily pain, vitality, and mental health, with higher baseline resilience being associated with a steeper decline, possibly due to floor or ceiling effects. Patients with lower socioeconomic status, educational level, and older age had a lower health-related quality of life. Conclusion: Physical health-related quality of life among breast cancer patients declined 1 year post-diagnosis, whereas mental health-related quality of life improved. Low resilient patients may be especially vulnerable at diagnosis. Biopsychosocial assessment at diagnosis can help identify patients who may require additional support. A multidimensional treatment plan should be started early to help overcome the problems in everyday activities.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
biopsychosocial (BPS) model, breast cancer, breast cancer treatment, health-related quality of life (HRQL), longitudinal study, multidisciplinary, psychological resilience, tumor characteristics
in
Frontiers in Oncology
volume
12
article number
891850
publisher
Frontiers Media S. A.
external identifiers
  • scopus:85137998843
  • pmid:36052232
ISSN
2234-943X
DOI
10.3389/fonc.2022.891850
language
English
LU publication?
yes
id
0dd6df6a-2fc2-4016-b18c-93ec338d641f
date added to LUP
2022-11-30 13:05:14
date last changed
2024-12-11 16:10:07
@article{0dd6df6a-2fc2-4016-b18c-93ec338d641f,
  abstract     = {{<p>Aim: This study investigated the changes in health-related quality of life from diagnosis to 1 year after diagnosis in breast cancer (BC) patients and the influence of clinical, psychological, and sociodemographic variables. An additional aim was to explore the mediating and moderating effects of resilience on changes in health-related quality of life. Methods: A longitudinal population-based study was conducted in southern Sweden. Newly diagnosed BC patients filled in measures of health-related quality of life, resilience, and sociodemographic variables at diagnosis (N = 980) and 1 year post-diagnosis (N = 780). Clinical variables were extracted from the Swedish national breast cancer quality registry. Mixed-model analyses were performed. Results: Most health-related quality of life outcomes declined from diagnosis to 1 year post-diagnosis. Role limitations due to emotional problems remained the same, whereas mental health improved. Lower health-related quality of life outcomes were associated with symptomatic detection and axillary dissection. Patients with a higher TNM stage and histologic grade and estrogen receptor (ER)-negative and human epidermal growth factor 2 (HER2)-positive status, who received chemotherapy, antibody therapy, or bisphosphonate therapy, had a steeper decline in outcomes. Changes in resilience were positively associated with all outcomes but did not mediate or moderate changes in any. Resilience at baseline moderated changes in bodily pain, vitality, and mental health, with higher baseline resilience being associated with a steeper decline, possibly due to floor or ceiling effects. Patients with lower socioeconomic status, educational level, and older age had a lower health-related quality of life. Conclusion: Physical health-related quality of life among breast cancer patients declined 1 year post-diagnosis, whereas mental health-related quality of life improved. Low resilient patients may be especially vulnerable at diagnosis. Biopsychosocial assessment at diagnosis can help identify patients who may require additional support. A multidimensional treatment plan should be started early to help overcome the problems in everyday activities.</p>}},
  author       = {{Veličković, Katarina and Borrebaeck, Carl A.K. and Bendahl, Pär Ola and Hegardt, Cecilia and Johnsson, Per and Richter, Corinna and Rydén, Lisa and Hallberg, Ingalill Rahm}},
  issn         = {{2234-943X}},
  keywords     = {{biopsychosocial (BPS) model; breast cancer; breast cancer treatment; health-related quality of life (HRQL); longitudinal study; multidisciplinary; psychological resilience; tumor characteristics}},
  language     = {{eng}},
  month        = {{08}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Oncology}},
  title        = {{One-year recovery from breast cancer : Importance of tumor and treatment-related factors, resilience, and sociodemographic factors for health-related quality of life}},
  url          = {{http://dx.doi.org/10.3389/fonc.2022.891850}},
  doi          = {{10.3389/fonc.2022.891850}},
  volume       = {{12}},
  year         = {{2022}},
}