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Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease

Hagell, Peter LU ; Crabb, L ; Pogarell, O ; Schrag, A ; Widner, Håkan LU ; Brooks, D J ; Oertel, W H ; Quinn, N P and Lindvall, Olle LU (2000) In Movement Disorders 15(2). p.224-229
Abstract
Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown longterm graft survival and therapeutically valuable improvements with decreased L-dopa dose and time spent in the "off"-phase, and reduced rigidity and hypokinesia. We have measured health-related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking... (More)
Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown longterm graft survival and therapeutically valuable improvements with decreased L-dopa dose and time spent in the "off"-phase, and reduced rigidity and hypokinesia. We have measured health-related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking improvements within different dimensions of the NHP as well as the NHP distress index (NHPD). The most pronounced improvements after grafting were observed for physical mobility along with emotional reactions and energy. These results indicate that intrastriatal transplantation of embryonic dopaminergic tissue can give rise to improvements within most areas of HRQoL, and that HRQoL measurements provide important information additional to that obtained by traditional, symptom-oriented assessment protocols. However, the optimal approach to HRQoL measurement in PD remains to be determined. (Less)
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Parkinson's disease, Transplantation, Health-related quality of life, Nottingham Health Profile
in
Movement Disorders
volume
15
issue
2
pages
224 - 229
publisher
John Wiley and Sons
external identifiers
  • pmid:10752570
  • scopus:0034073869
ISSN
0885-3185
DOI
10.1002/1531-8257(200003)15:2<224::AID-MDS1004>3.0.CO;2-W
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Caring Sciences (Closed 2012) (016514020), Neurology, Lund (013027000)
id
d33e85bd-8c4e-4f6b-9e8b-b1738df51076 (old id 1117019)
date added to LUP
2016-04-01 12:19:22
date last changed
2021-01-06 03:04:24
@article{d33e85bd-8c4e-4f6b-9e8b-b1738df51076,
  abstract     = {Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown longterm graft survival and therapeutically valuable improvements with decreased L-dopa dose and time spent in the "off"-phase, and reduced rigidity and hypokinesia. We have measured health-related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking improvements within different dimensions of the NHP as well as the NHP distress index (NHPD). The most pronounced improvements after grafting were observed for physical mobility along with emotional reactions and energy. These results indicate that intrastriatal transplantation of embryonic dopaminergic tissue can give rise to improvements within most areas of HRQoL, and that HRQoL measurements provide important information additional to that obtained by traditional, symptom-oriented assessment protocols. However, the optimal approach to HRQoL measurement in PD remains to be determined.},
  author       = {Hagell, Peter and Crabb, L and Pogarell, O and Schrag, A and Widner, Håkan and Brooks, D J and Oertel, W H and Quinn, N P and Lindvall, Olle},
  issn         = {0885-3185},
  language     = {eng},
  number       = {2},
  pages        = {224--229},
  publisher    = {John Wiley and Sons},
  series       = {Movement Disorders},
  title        = {Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease},
  url          = {http://dx.doi.org/10.1002/1531-8257(200003)15:2<224::AID-MDS1004>3.0.CO;2-W},
  doi          = {10.1002/1531-8257(200003)15:2<224::AID-MDS1004>3.0.CO;2-W},
  volume       = {15},
  year         = {2000},
}