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Clinical lacunar syndromes as predictors of lacunar infarcts. A comparison of acute clinical lacunar syndromes and findings on diffusion-weighted MRI

Lindgren, Arne LU ; Staaf, Gert LU ; Geijer, Bo LU ; Brockstedt, Sara LU ; Ståhlberg, Freddy LU ; Holtås, Stig LU and Norrving, Bo LU (2000) In Acta Neurologica Scandinavica 101(2). p.128-134
Abstract
OBJECTIVES: To evaluate if patients with acute lacunar syndromes have acute lacunar infarcts or other types of cerebral lesions on diffusion-weighted MRI. METHODS: Patients with acute lacunar syndromes underwent echo-planar diffusion MRI of the brain within 3 days after stroke onset. Localization and size of lesions with hyperintense signal were determined, compared with clinical characteristics and with findings on follow-up T2-weighted MRI. RESULTS: Twenty-three patients participated in the study. Thirteen patients had pure motor stroke, 1 pure sensory stroke, 8 sensorimotor stroke, and 1 ataxic hemiparesis. Twenty-two patients had at least one lesion with increased signal on diffusion-weighted MR images. These acute lesions were in the... (More)
OBJECTIVES: To evaluate if patients with acute lacunar syndromes have acute lacunar infarcts or other types of cerebral lesions on diffusion-weighted MRI. METHODS: Patients with acute lacunar syndromes underwent echo-planar diffusion MRI of the brain within 3 days after stroke onset. Localization and size of lesions with hyperintense signal were determined, compared with clinical characteristics and with findings on follow-up T2-weighted MRI. RESULTS: Twenty-three patients participated in the study. Thirteen patients had pure motor stroke, 1 pure sensory stroke, 8 sensorimotor stroke, and 1 ataxic hemiparesis. Twenty-two patients had at least one lesion with increased signal on diffusion-weighted MR images. These acute lesions were in the internal capsule/ basal ganglia/thalamus in 13 patients, subcortical white matter in 5 patients, brainstem in 2 patients, cortex (multiple small lesions) in 1 patient, and cortex + basal ganglia in 1 patient. The median volume of the lesions was 0.6 ml on the initial examination and on follow-up, of 17 patients after 1 to 5 months, 0.5 ml. CONCLUSIONS: Almost all patients with acute ischemic lacunar syndromes have acute lesions on echo-planar diffusion-weighted MRI within 3 days after stroke onset. These lesions are mostly small and subcortical, compatible with lacunar infarcts caused by single penetrating artery occlusion, but in a minor proportion of patients (2 of 23 in our study) a cortical involvement is found. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
diffusion MRI, cerebral infarction, stroke, acute, lacunar syndrome, lacunar infarct
in
Acta Neurologica Scandinavica
volume
101
issue
2
pages
128 - 134
publisher
Wiley-Blackwell
external identifiers
  • pmid:10685861
  • scopus:0033983689
ISSN
1600-0404
DOI
10.1034/j.1600-0404.2000.101002128.x
language
English
LU publication?
yes
id
8a47b6c5-042e-48ab-832d-4a77d9ed6cc2 (old id 1117063)
date added to LUP
2008-07-03 12:54:53
date last changed
2017-01-01 06:43:54
@article{8a47b6c5-042e-48ab-832d-4a77d9ed6cc2,
  abstract     = {OBJECTIVES: To evaluate if patients with acute lacunar syndromes have acute lacunar infarcts or other types of cerebral lesions on diffusion-weighted MRI. METHODS: Patients with acute lacunar syndromes underwent echo-planar diffusion MRI of the brain within 3 days after stroke onset. Localization and size of lesions with hyperintense signal were determined, compared with clinical characteristics and with findings on follow-up T2-weighted MRI. RESULTS: Twenty-three patients participated in the study. Thirteen patients had pure motor stroke, 1 pure sensory stroke, 8 sensorimotor stroke, and 1 ataxic hemiparesis. Twenty-two patients had at least one lesion with increased signal on diffusion-weighted MR images. These acute lesions were in the internal capsule/ basal ganglia/thalamus in 13 patients, subcortical white matter in 5 patients, brainstem in 2 patients, cortex (multiple small lesions) in 1 patient, and cortex + basal ganglia in 1 patient. The median volume of the lesions was 0.6 ml on the initial examination and on follow-up, of 17 patients after 1 to 5 months, 0.5 ml. CONCLUSIONS: Almost all patients with acute ischemic lacunar syndromes have acute lesions on echo-planar diffusion-weighted MRI within 3 days after stroke onset. These lesions are mostly small and subcortical, compatible with lacunar infarcts caused by single penetrating artery occlusion, but in a minor proportion of patients (2 of 23 in our study) a cortical involvement is found.},
  author       = {Lindgren, Arne and Staaf, Gert and Geijer, Bo and Brockstedt, Sara and Ståhlberg, Freddy and Holtås, Stig and Norrving, Bo},
  issn         = {1600-0404},
  keyword      = {diffusion MRI,cerebral infarction,stroke,acute,lacunar syndrome,lacunar infarct},
  language     = {eng},
  number       = {2},
  pages        = {128--134},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Neurologica Scandinavica},
  title        = {Clinical lacunar syndromes as predictors of lacunar infarcts. A comparison of acute clinical lacunar syndromes and findings on diffusion-weighted MRI},
  url          = {http://dx.doi.org/10.1034/j.1600-0404.2000.101002128.x},
  volume       = {101},
  year         = {2000},
}