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The Malmo model for immune tolerance induction: impact of previous treatment on outcome

Carlborg, E; Astermark, Jan LU ; Lethagen, Stefan LU ; Ljung, Rolf LU and Berntorp, Erik LU (2000) In Haemophilia 6(6). p.639-639
Abstract
Ten patients, who had been treated according to the Malmo model for immune tolerance induction (ITI), were analysed regarding treatment with clotting factors and chemotherapy during the time period between inhibitor detection and ITI. Of the patients who were successfully rendered tolerant (n=6) all but one had received treatment with FVIII, either alone (n=1), or combined with cyclophosphamide (n=4). Of the patients who did not become tolerant, three of four had received treatment with FVIII during the inhibitor period but only one with FVIII and chemotherapy. The total amount of treatment received was in general much lower in the group that did not become tolerant. In individual cases, it appeared very clear that the inhibitor level and... (More)
Ten patients, who had been treated according to the Malmo model for immune tolerance induction (ITI), were analysed regarding treatment with clotting factors and chemotherapy during the time period between inhibitor detection and ITI. Of the patients who were successfully rendered tolerant (n=6) all but one had received treatment with FVIII, either alone (n=1), or combined with cyclophosphamide (n=4). Of the patients who did not become tolerant, three of four had received treatment with FVIII during the inhibitor period but only one with FVIII and chemotherapy. The total amount of treatment received was in general much lower in the group that did not become tolerant. In individual cases, it appeared very clear that the inhibitor level and anamnestic response was substantially reduced prior to the ITI using the Malmo treatment model. We conclude that treatment of acute bleeds during the inhibitor period may be of importance for ITI and that the different response rates published for different immune tolerance regimens most likely do not reflect the true response rate for the respective regimen. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Haemophilia
volume
6
issue
6
pages
639 - 639
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • pmid:11122389
  • scopus:0033625967
ISSN
1351-8216
DOI
10.1046/j.1365-2516.2000.00436.x
language
English
LU publication?
yes
id
1400f4a7-9813-4c13-8a01-4c33a501b989 (old id 1117535)
date added to LUP
2008-06-27 14:21:42
date last changed
2017-07-09 04:31:59
@article{1400f4a7-9813-4c13-8a01-4c33a501b989,
  abstract     = {Ten patients, who had been treated according to the Malmo model for immune tolerance induction (ITI), were analysed regarding treatment with clotting factors and chemotherapy during the time period between inhibitor detection and ITI. Of the patients who were successfully rendered tolerant (n=6) all but one had received treatment with FVIII, either alone (n=1), or combined with cyclophosphamide (n=4). Of the patients who did not become tolerant, three of four had received treatment with FVIII during the inhibitor period but only one with FVIII and chemotherapy. The total amount of treatment received was in general much lower in the group that did not become tolerant. In individual cases, it appeared very clear that the inhibitor level and anamnestic response was substantially reduced prior to the ITI using the Malmo treatment model. We conclude that treatment of acute bleeds during the inhibitor period may be of importance for ITI and that the different response rates published for different immune tolerance regimens most likely do not reflect the true response rate for the respective regimen.},
  author       = {Carlborg, E and Astermark, Jan and Lethagen, Stefan and Ljung, Rolf and Berntorp, Erik},
  issn         = {1351-8216},
  language     = {eng},
  number       = {6},
  pages        = {639--639},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Haemophilia},
  title        = {The Malmo model for immune tolerance induction: impact of previous treatment on outcome},
  url          = {http://dx.doi.org/10.1046/j.1365-2516.2000.00436.x},
  volume       = {6},
  year         = {2000},
}