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The environmental determinants of diabetes in the young (TEDDY) study: Study design

TEDDY study group, The; Lernmark, Åke LU ; Almgren, Peter LU ; Andrén Aronsson, Carin LU ; Andersson, Eva; Bianconi Svensson, Sylvia LU ; Carlsson, Ulla-Marie; Cilio, Corrado LU ; Gerardsson, Joanna LU and Gustavsson, Barbro LU , et al. (2007) In Pediatric Diabetes 8(5). p.286-298
Abstract
The primary objective of this multicenter, multinational, epidemiological study is the identification of infectious agents, dietary factors, or other environmental exposures that are associated with increased risk of autoimmunity and type 1 diabetes mellitus (T1DM). Factors affecting specific phenotypic manifestations such as early age of onset or rate of progression or with protection from the development of T1DM will also be identified. The Environmental Determinants of Diabetes in the Young (TEDDY) is an observational cohort study in which newborns who are younger than 4 months and have high-risk human leukocyte antigen alleles in the general population or are first-degree relatives (FDRs) of patients affected with T1DM will be... (More)
The primary objective of this multicenter, multinational, epidemiological study is the identification of infectious agents, dietary factors, or other environmental exposures that are associated with increased risk of autoimmunity and type 1 diabetes mellitus (T1DM). Factors affecting specific phenotypic manifestations such as early age of onset or rate of progression or with protection from the development of T1DM will also be identified. The Environmental Determinants of Diabetes in the Young (TEDDY) is an observational cohort study in which newborns who are younger than 4 months and have high-risk human leukocyte antigen alleles in the general population or are first-degree relatives (FDRs) of patients affected with T1DM will be enrolled. Six clinical centers in the USA and Europe will screen 361 588 newborns, of which it is anticipated that 17 804 will be eligible for enrollment with just over 7800 followed. Recruitment will occur over 5 yr, with children being followed to the age of 15 yr. Identification of such factors will lead to a better understanding of disease pathogenesis and result in new strategies to prevent, delay, or reverse T1DM. (Less)
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type
Contribution to journal
publication status
published
subject
keywords
psychosocial factors, infectious agents factors, islet autoimmunity, HLA, epidemiological study, environmental triggers, dietary factors, T1DM
in
Pediatric Diabetes
volume
8
issue
5
pages
286 - 298
publisher
Wiley-Blackwell
external identifiers
  • scopus:34548783929
ISSN
1399-543X
DOI
10.1111/j.1399-5448.2007.00269.x
language
English
LU publication?
yes
id
041097fd-7a5c-4b9c-a6ff-09eafe27588e (old id 1138303)
date added to LUP
2008-08-01 13:43:51
date last changed
2017-11-05 03:28:10
@article{041097fd-7a5c-4b9c-a6ff-09eafe27588e,
  abstract     = {The primary objective of this multicenter, multinational, epidemiological study is the identification of infectious agents, dietary factors, or other environmental exposures that are associated with increased risk of autoimmunity and type 1 diabetes mellitus (T1DM). Factors affecting specific phenotypic manifestations such as early age of onset or rate of progression or with protection from the development of T1DM will also be identified. The Environmental Determinants of Diabetes in the Young (TEDDY) is an observational cohort study in which newborns who are younger than 4 months and have high-risk human leukocyte antigen alleles in the general population or are first-degree relatives (FDRs) of patients affected with T1DM will be enrolled. Six clinical centers in the USA and Europe will screen 361 588 newborns, of which it is anticipated that 17 804 will be eligible for enrollment with just over 7800 followed. Recruitment will occur over 5 yr, with children being followed to the age of 15 yr. Identification of such factors will lead to a better understanding of disease pathogenesis and result in new strategies to prevent, delay, or reverse T1DM.},
  author       = {TEDDY study group, The and Lernmark, Åke and Almgren, Peter and Andrén Aronsson, Carin and Andersson, Eva and Bianconi Svensson, Sylvia and Carlsson, Ulla-Marie and Cilio, Corrado and Gerardsson, Joanna and Gustavsson, Barbro and Hansson, Anna and Hansson, Gertie and Jönsson, Ida and Ivarsson, Sten and Larsson, Helena and Karlsson, Elli and Papadopoulou, Anastasia and Lernmark, Barbro and Massadakis, Theodosia and Ramelius, Anita and Sedig-Järvirova, Monica and Sjöberg, Birgitta and Wallin, Anne and Wimar, Åsa},
  issn         = {1399-543X},
  keyword      = {psychosocial factors,infectious agents factors,islet autoimmunity,HLA,epidemiological study,environmental triggers,dietary factors,T1DM},
  language     = {eng},
  number       = {5},
  pages        = {286--298},
  publisher    = {Wiley-Blackwell},
  series       = {Pediatric Diabetes},
  title        = {The environmental determinants of diabetes in the young (TEDDY) study: Study design},
  url          = {http://dx.doi.org/10.1111/j.1399-5448.2007.00269.x},
  volume       = {8},
  year         = {2007},
}