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Variation in fasting and non-fasting serum enterolactone concentrations in women of the Malmo Diet and Cancer cohort

Sonestedt, Emily LU ; Ericson, Ulrika LU ; Gullberg, Bo LU ; Penalvo, JL; Adlercreutz, H and Wirfält, Elisabet LU (2008) In European Journal of Clinical Nutrition 62(8). p.1005-1009
Abstract
Objectives:The aim of this study was to examine the variation of enterolactone from fasting and non-fasting blood of middle-aged healthy women eating a normal diet to determine the usefulness of a single sample in epidemiological studies.Subjects and methods:Twenty-six women born between 1940 and 1950 were recruited within the Malmo Diet and Cancer cohort. Three non-fasting and two overnight fasting samples were collected from each individual during a 5-week period. Twenty-one participated in all measurements. Enterolactone concentrations were analyzed by time-resolved fluoroimmunoassay.Results:The within-subject and between-subject variations (coefficient of variations, CV) were estimated to 59 and 89% respectively for fasting samples and... (More)
Objectives:The aim of this study was to examine the variation of enterolactone from fasting and non-fasting blood of middle-aged healthy women eating a normal diet to determine the usefulness of a single sample in epidemiological studies.Subjects and methods:Twenty-six women born between 1940 and 1950 were recruited within the Malmo Diet and Cancer cohort. Three non-fasting and two overnight fasting samples were collected from each individual during a 5-week period. Twenty-one participated in all measurements. Enterolactone concentrations were analyzed by time-resolved fluoroimmunoassay.Results:The within-subject and between-subject variations (coefficient of variations, CV) were estimated to 59 and 89% respectively for fasting samples and 71 and 67% for non-fasting samples. The intraclass correlation coefficients (ICC) were estimated to 0.66 (95% confidence interval (CI) 0.35-0.84) for fasting and 0.48 (95% CI, 0.22-0.72) for non-fasting samples.Conclusions:Although the estimated ICC for blood samples was moderate, it indicates that enterolactone levels of both fasting and non-fasting blood samples should be useful in future projects within the Malmo Diet and Cancer cohort.European Journal of Clinical Nutrition advance online publication, 30 May 2007; doi:10.1038/sj.ejcn.1602811. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Clinical Nutrition
volume
62
issue
8
pages
1005 - 1009
publisher
Nature Publishing Group
external identifiers
  • pmid:17538540
  • wos:000258220700010
  • scopus:49349116831
ISSN
1476-5640
DOI
10.1038/sj.ejcn.1602811
language
English
LU publication?
yes
id
e2941ac8-5578-4328-80b4-57adc935a054 (old id 1141788)
date added to LUP
2008-08-11 14:02:33
date last changed
2017-02-19 04:00:14
@article{e2941ac8-5578-4328-80b4-57adc935a054,
  abstract     = {Objectives:The aim of this study was to examine the variation of enterolactone from fasting and non-fasting blood of middle-aged healthy women eating a normal diet to determine the usefulness of a single sample in epidemiological studies.Subjects and methods:Twenty-six women born between 1940 and 1950 were recruited within the Malmo Diet and Cancer cohort. Three non-fasting and two overnight fasting samples were collected from each individual during a 5-week period. Twenty-one participated in all measurements. Enterolactone concentrations were analyzed by time-resolved fluoroimmunoassay.Results:The within-subject and between-subject variations (coefficient of variations, CV) were estimated to 59 and 89% respectively for fasting samples and 71 and 67% for non-fasting samples. The intraclass correlation coefficients (ICC) were estimated to 0.66 (95% confidence interval (CI) 0.35-0.84) for fasting and 0.48 (95% CI, 0.22-0.72) for non-fasting samples.Conclusions:Although the estimated ICC for blood samples was moderate, it indicates that enterolactone levels of both fasting and non-fasting blood samples should be useful in future projects within the Malmo Diet and Cancer cohort.European Journal of Clinical Nutrition advance online publication, 30 May 2007; doi:10.1038/sj.ejcn.1602811.},
  author       = {Sonestedt, Emily and Ericson, Ulrika and Gullberg, Bo and Penalvo, JL and Adlercreutz, H and Wirfält, Elisabet},
  issn         = {1476-5640},
  language     = {eng},
  number       = {8},
  pages        = {1005--1009},
  publisher    = {Nature Publishing Group},
  series       = {European Journal of Clinical Nutrition},
  title        = {Variation in fasting and non-fasting serum enterolactone concentrations in women of the Malmo Diet and Cancer cohort},
  url          = {http://dx.doi.org/10.1038/sj.ejcn.1602811},
  volume       = {62},
  year         = {2008},
}