On-demand vs. prophylactic treatment for severe haemophilia in Norway and Sweden: differences in treatment characteristics and outcome.
(2003) In Haemophilia 9(5). p.555-566- Abstract
- Using an 11-year panel of 156 Norwegian and Swedish patients with severe haemophilia, and including retrospective case-book data from birth, we compared the differences in the haemophilia-related resource use between on-demand and prophylactic treatment. Patients treated on-demand had more surgery (arthrodeses, prostheses implantations and synovectomies) and more days lost from work. Median annual factor-concentrate consumption among adults (18+) was 211 000 IU [interquartile range (IQR) 154 000-268 000] or 3 024 IU kg-1 year-1 for patients on prophylactic treatment and 55 000 IU (IQR 28 000-91 000) for on-demand patients (780 IU kg-1 year-1). This was partly explained by the fact that the median dose per kg body weight was twice as great... (More)
- Using an 11-year panel of 156 Norwegian and Swedish patients with severe haemophilia, and including retrospective case-book data from birth, we compared the differences in the haemophilia-related resource use between on-demand and prophylactic treatment. Patients treated on-demand had more surgery (arthrodeses, prostheses implantations and synovectomies) and more days lost from work. Median annual factor-concentrate consumption among adults (18+) was 211 000 IU [interquartile range (IQR) 154 000-268 000] or 3 024 IU kg-1 year-1 for patients on prophylactic treatment and 55 000 IU (IQR 28 000-91 000) for on-demand patients (780 IU kg-1 year-1). This was partly explained by the fact that the median dose per kg body weight was twice as great 28, (IQR 24-32) for prophylaxis compared with 14 (IQR 12-16) for on-demand. Prescribed dose per kg body weight was found to be an important factor explaining the variation in total annual factor-concentrate consumption per patient for both types of treatment. Other variables included in the panel-data regression analysis were the number of weeks on secondary prophylaxis for on-demand patients and age, body weight and type of haemophilia for children (0-17 years) on prophylaxis. Differences were consistently substantial and will affect both costs and benefits of the two treatment strategies. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/117653
- author
- Steen Carlsson, Katarina LU ; Höjgård, Sören LU ; Glomstein, A. ; Lethagen, Stefan LU ; Schulman, S. ; Tengborn, Lilian LU ; Lindgren, Anna LU ; Berntorp, Erik LU and Lindgren, Björn LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Haemophilia
- volume
- 9
- issue
- 5
- pages
- 555 - 566
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000185551700004
- pmid:14511294
- scopus:0141955854
- ISSN
- 1351-8216
- DOI
- 10.1046/j.1365-2516.2003.00817.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Mathematical Statistics (011015003), Clinical Coagulation Research Unit (013242510), Division of Health Economics and Forensic Medicine (Closed 2012) (013040050), Emergency medicine/Medicine/Surgery (013240200)
- id
- ee05e45f-4947-47ad-98aa-74581bcb7da0 (old id 117653)
- date added to LUP
- 2016-04-01 11:59:42
- date last changed
- 2023-09-01 15:14:24
@article{ee05e45f-4947-47ad-98aa-74581bcb7da0, abstract = {{Using an 11-year panel of 156 Norwegian and Swedish patients with severe haemophilia, and including retrospective case-book data from birth, we compared the differences in the haemophilia-related resource use between on-demand and prophylactic treatment. Patients treated on-demand had more surgery (arthrodeses, prostheses implantations and synovectomies) and more days lost from work. Median annual factor-concentrate consumption among adults (18+) was 211 000 IU [interquartile range (IQR) 154 000-268 000] or 3 024 IU kg-1 year-1 for patients on prophylactic treatment and 55 000 IU (IQR 28 000-91 000) for on-demand patients (780 IU kg-1 year-1). This was partly explained by the fact that the median dose per kg body weight was twice as great 28, (IQR 24-32) for prophylaxis compared with 14 (IQR 12-16) for on-demand. Prescribed dose per kg body weight was found to be an important factor explaining the variation in total annual factor-concentrate consumption per patient for both types of treatment. Other variables included in the panel-data regression analysis were the number of weeks on secondary prophylaxis for on-demand patients and age, body weight and type of haemophilia for children (0-17 years) on prophylaxis. Differences were consistently substantial and will affect both costs and benefits of the two treatment strategies.}}, author = {{Steen Carlsson, Katarina and Höjgård, Sören and Glomstein, A. and Lethagen, Stefan and Schulman, S. and Tengborn, Lilian and Lindgren, Anna and Berntorp, Erik and Lindgren, Björn}}, issn = {{1351-8216}}, language = {{eng}}, number = {{5}}, pages = {{555--566}}, publisher = {{Wiley-Blackwell}}, series = {{Haemophilia}}, title = {{On-demand vs. prophylactic treatment for severe haemophilia in Norway and Sweden: differences in treatment characteristics and outcome.}}, url = {{https://lup.lub.lu.se/search/files/2735443/623860.pdf}}, doi = {{10.1046/j.1365-2516.2003.00817.x}}, volume = {{9}}, year = {{2003}}, }