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The gender differences in growth hormone-binding protein and leptin persist in 80-year-old men and women and is not caused by sex hormones.

Bülow, B; Ahrén, Bo LU ; Fisker, S; Dehlin, Ove LU ; Hagberg, B; Jensen, E; Svensson, Torbjörn LU ; Samuelsson, Gillis LU and Erfurth, Eva Marie LU (2003) In Clinical Endocrinology 59(4). p.6-482
Abstract
objective Leptin and growth hormone-binding protein (GHBP) both show gender differences that might be explained by sex hormones. To study the potential relevance of oestradiol and testosterone, we have examined 80-year-old subjects in whom oestradiol is higher in men than in women. The interrelationships between leptin, insulin, GHBP and fat mass in this age group were also investigated.



design and subjects Ninety-four subjects (55 females and 39 males), all 80 years old, were investigated in a community-based study. None of the investigated subjects was being treated for diabetes mellitus and none of the women had oestrogen replacement.



methods Levels of testosterone, oestradiol, SHBG, IGF-I, GHBP,... (More)
objective Leptin and growth hormone-binding protein (GHBP) both show gender differences that might be explained by sex hormones. To study the potential relevance of oestradiol and testosterone, we have examined 80-year-old subjects in whom oestradiol is higher in men than in women. The interrelationships between leptin, insulin, GHBP and fat mass in this age group were also investigated.



design and subjects Ninety-four subjects (55 females and 39 males), all 80 years old, were investigated in a community-based study. None of the investigated subjects was being treated for diabetes mellitus and none of the women had oestrogen replacement.



methods Levels of testosterone, oestradiol, SHBG, IGF-I, GHBP, glucose, insulin and leptin were analysed. Body composition was measured with bioimpedance analysis (BIA).



results As in younger age groups, serum leptin, the ratio leptin/kilogram fat mass and serum GHBP were higher in the women (all, P <= 0·007), although serum oestradiol was higher in the men (P < 0·001). There were no significant associations between sex hormones and leptin or GHBP either in women or in men (all, r < 0·13, P > 0·1). Leptin correlated to kilogram fat mass in both women (r = 0·55, P < 0·001) and men (r = 0·47, P = 0·003), but in contrast, there were no significant correlations between GHBP and fat mass and GHBP and IGF-I, either in women or in men (all, r < 0·24, P > 0·2). Insulin and leptin were significantly associated with GHBP, both in women (r = 0·48, P < 0·001 and r = 0·43, P = 0·001, respectively) and in men (r = 0·40, P = 0·01 and r = 0·34, P = 0·03, respectively).



conclusions Although the 80-year-old men had higher oestradiol levels than the women, the women had higher levels of leptin and GHBP. There were no correlations between sex hormones and leptin and GHBP, which indicates that the gender differences are not caused by sex hormones in old age. In contrast to studies in younger subjects, GHBP did not correlate to fat mass in the investigated 80-year-old men and women. In the older subjects investigated, as in younger subjects, GHBP was significantly correlated with leptin and insulin. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Endocrinology
volume
59
issue
4
pages
6 - 482
publisher
Wiley-Blackwell
external identifiers
  • scopus:0141504965
ISSN
1365-2265
DOI
language
English
LU publication?
yes
id
d08ef192-7efd-4c99-8dec-c93410787d90 (old id 118411)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=14510911&ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
date added to LUP
2007-06-27 14:13:43
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2018-05-29 09:51:49
@article{d08ef192-7efd-4c99-8dec-c93410787d90,
  abstract     = {objective Leptin and growth hormone-binding protein (GHBP) both show gender differences that might be explained by sex hormones. To study the potential relevance of oestradiol and testosterone, we have examined 80-year-old subjects in whom oestradiol is higher in men than in women. The interrelationships between leptin, insulin, GHBP and fat mass in this age group were also investigated.<br/><br>
<br/><br>
design and subjects Ninety-four subjects (55 females and 39 males), all 80 years old, were investigated in a community-based study. None of the investigated subjects was being treated for diabetes mellitus and none of the women had oestrogen replacement.<br/><br>
<br/><br>
methods Levels of testosterone, oestradiol, SHBG, IGF-I, GHBP, glucose, insulin and leptin were analysed. Body composition was measured with bioimpedance analysis (BIA).<br/><br>
<br/><br>
results As in younger age groups, serum leptin, the ratio leptin/kilogram fat mass and serum GHBP were higher in the women (all, P &lt;= 0·007), although serum oestradiol was higher in the men (P &lt; 0·001). There were no significant associations between sex hormones and leptin or GHBP either in women or in men (all, r &lt; 0·13, P &gt; 0·1). Leptin correlated to kilogram fat mass in both women (r = 0·55, P &lt; 0·001) and men (r = 0·47, P = 0·003), but in contrast, there were no significant correlations between GHBP and fat mass and GHBP and IGF-I, either in women or in men (all, r &lt; 0·24, P &gt; 0·2). Insulin and leptin were significantly associated with GHBP, both in women (r = 0·48, P &lt; 0·001 and r = 0·43, P = 0·001, respectively) and in men (r = 0·40, P = 0·01 and r = 0·34, P = 0·03, respectively).<br/><br>
<br/><br>
conclusions Although the 80-year-old men had higher oestradiol levels than the women, the women had higher levels of leptin and GHBP. There were no correlations between sex hormones and leptin and GHBP, which indicates that the gender differences are not caused by sex hormones in old age. In contrast to studies in younger subjects, GHBP did not correlate to fat mass in the investigated 80-year-old men and women. In the older subjects investigated, as in younger subjects, GHBP was significantly correlated with leptin and insulin.},
  author       = {Bülow, B and Ahrén, Bo and Fisker, S and Dehlin, Ove and Hagberg, B and Jensen, E and Svensson, Torbjörn and Samuelsson, Gillis and Erfurth, Eva Marie},
  issn         = {1365-2265},
  language     = {eng},
  number       = {4},
  pages        = {6--482},
  publisher    = {Wiley-Blackwell},
  series       = {Clinical Endocrinology},
  title        = {The gender differences in growth hormone-binding protein and leptin persist in 80-year-old men and women and is not caused by sex hormones.},
  url          = {http://dx.doi.org/},
  volume       = {59},
  year         = {2003},
}