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Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition

Crowe, Francesca L.; Key, Timothy J.; Appleby, Paul N.; Travis, Ruth C.; Overvad, Kim; Jakobsen, Marianne U.; Johnsen, Nina F.; Tjonneland, Anne; Linseisen, Jakob and Rohrmann, Sabine, et al. (2008) In American Journal of Clinical Nutrition 87(5). p.1405-1413
Abstract
Background: Findings from early observational studies have suggested that the intake of dietary fat might be a contributing factor in the etiology of prostate cancer. However, the results from more recent prospective studies do not support this hypothesis, and the possible association between different food sources of fat and prostate cancer risk also remains unclear. Objective: The objectives were to assess whether intakes of dietary fat, subtypes of fat, and fat from animal products were associated with prostate cancer risk. Design: This was a multicenter prospective study of 142 520 men in the European Prospective Investigation into Cancer and Nutrition (EPIC). Dietary fat intake was estimated with the use of country-specific validated... (More)
Background: Findings from early observational studies have suggested that the intake of dietary fat might be a contributing factor in the etiology of prostate cancer. However, the results from more recent prospective studies do not support this hypothesis, and the possible association between different food sources of fat and prostate cancer risk also remains unclear. Objective: The objectives were to assess whether intakes of dietary fat, subtypes of fat, and fat from animal products were associated with prostate cancer risk. Design: This was a multicenter prospective study of 142 520 men in the European Prospective Investigation into Cancer and Nutrition (EPIC). Dietary fat intake was estimated with the use of country-specific validated food questionnaires. The association between dietary fat and risk of prostate cancer was assessed by using Cox regression, stratified by recruitment center and adjusted for height, weight, smoking, education, marital status, and energy intake. Results: After a median follow-up time of 8.7 y, prostate cancer was diagnosed in 2727 men. There was no significant association between dietary fat (total, saturated, monounsaturated, and polyunsaturated fat and the ratio of polyunsaturated to saturated fat) and risk of prostate cancer. The hazard ratio for prostate cancer for the highest versus the lowest quintile of total fat intake was 0.96 (95% CI: 0.84, 1.09; P for trend = 0.155). There were no significant associations between prostate cancer risk and fat from red meat, dairy products, and fish. Conclusion: The results from this large multicenter study suggest that there is no association between dietary fat and prostate cancer risk. (Less)
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American Journal of Clinical Nutrition
volume
87
issue
5
pages
1405 - 1413
publisher
American Society for Clinical Nutrition
external identifiers
  • wos:000255880500040
  • scopus:43549106350
ISSN
1938-3207
language
English
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yes
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6ab2fa88-56c9-44b9-a873-6d7fbfdc8fc1 (old id 1204458)
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http://www.ajcn.org/cgi/content/full/87/5/1405
date added to LUP
2008-09-17 13:58:12
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2017-06-04 03:53:03
@article{6ab2fa88-56c9-44b9-a873-6d7fbfdc8fc1,
  abstract     = {Background: Findings from early observational studies have suggested that the intake of dietary fat might be a contributing factor in the etiology of prostate cancer. However, the results from more recent prospective studies do not support this hypothesis, and the possible association between different food sources of fat and prostate cancer risk also remains unclear. Objective: The objectives were to assess whether intakes of dietary fat, subtypes of fat, and fat from animal products were associated with prostate cancer risk. Design: This was a multicenter prospective study of 142 520 men in the European Prospective Investigation into Cancer and Nutrition (EPIC). Dietary fat intake was estimated with the use of country-specific validated food questionnaires. The association between dietary fat and risk of prostate cancer was assessed by using Cox regression, stratified by recruitment center and adjusted for height, weight, smoking, education, marital status, and energy intake. Results: After a median follow-up time of 8.7 y, prostate cancer was diagnosed in 2727 men. There was no significant association between dietary fat (total, saturated, monounsaturated, and polyunsaturated fat and the ratio of polyunsaturated to saturated fat) and risk of prostate cancer. The hazard ratio for prostate cancer for the highest versus the lowest quintile of total fat intake was 0.96 (95% CI: 0.84, 1.09; P for trend = 0.155). There were no significant associations between prostate cancer risk and fat from red meat, dairy products, and fish. Conclusion: The results from this large multicenter study suggest that there is no association between dietary fat and prostate cancer risk.},
  author       = {Crowe, Francesca L. and Key, Timothy J. and Appleby, Paul N. and Travis, Ruth C. and Overvad, Kim and Jakobsen, Marianne U. and Johnsen, Nina F. and Tjonneland, Anne and Linseisen, Jakob and Rohrmann, Sabine and Boeing, Heiner and Pischon, Tobias and Trichopoulou, Antonia and Lagiou, Pagona and Trichopoulos, Dimitrios and Sacerdote, Carlotta and Palli, Domenico and Tumino, Rosario and Krogh, Vitorrio and Bueno-de-Mesquita, H. Bas and Kiemeney, Lambertus A. and Chirlaque, Maria-Dolores and Ardanaz, Eva and Sanchez, Maria-Jose and Larranaga, Nerea and Gonzalez, Carlos A. and Quiros, Jose R. and Manjer, Jonas and Wirfält, Elisabet and Stattin, Par and Hallmans, Goran and Khaw, Kay-Tee and Bingham, Sheila and Ferrari, Pietro and Slimani, Nadia and Jenab, Mazda and Riboli, Elio},
  issn         = {1938-3207},
  language     = {eng},
  number       = {5},
  pages        = {1405--1413},
  publisher    = {American Society for Clinical Nutrition},
  series       = {American Journal of Clinical Nutrition},
  title        = {Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition},
  volume       = {87},
  year         = {2008},
}