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Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls.

Fridberg, Marie LU ; Kjellström, Sofia; Anagnostaki, Lola; Skogvall, Ingela; Mustelin, Tomas; Wiebe, Thomas LU ; Persson, Jenny L LU ; Dictor, Michael LU and Gjörloff Wingren, Anette LU (2008) In Pediatric Hematology & Oncology 25(6). p.528-540
Abstract
Although many pediatric B-cell lymphoma patients are being cured today, much is still unknown about the pathogenesis of this disease. Protein tyrosine phosphatases are involved in the control of survival, growth, and differentiation of cells. The authors have analyzed 26 pediatric B-cell lymphoma cases for the expression of a panel of phosphatases and report a statistically significant lower expression intensity of PTEN and HePTP and higher nuclear SHP2 expression in B-cell lymphoma cases compared to lymphoid tissue. Knowledge about the expression of key regulatory proteins in pediatric B-cell lymphomas is necessary for revealing the complex molecular background of this disease.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Hematology & Oncology
volume
25
issue
6
pages
528 - 540
publisher
Hemisphere Pub. Corp.
external identifiers
  • wos:000258723900006
  • pmid:18728972
  • scopus:50249142447
ISSN
1521-0669
DOI
10.1080/08880010802237054
language
English
LU publication?
yes
id
389f122c-deb4-4f43-a8f4-8909a2eeadfc (old id 1222880)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18728972?dopt=Abstract
date added to LUP
2008-09-03 11:35:18
date last changed
2017-07-23 04:52:57
@article{389f122c-deb4-4f43-a8f4-8909a2eeadfc,
  abstract     = {Although many pediatric B-cell lymphoma patients are being cured today, much is still unknown about the pathogenesis of this disease. Protein tyrosine phosphatases are involved in the control of survival, growth, and differentiation of cells. The authors have analyzed 26 pediatric B-cell lymphoma cases for the expression of a panel of phosphatases and report a statistically significant lower expression intensity of PTEN and HePTP and higher nuclear SHP2 expression in B-cell lymphoma cases compared to lymphoid tissue. Knowledge about the expression of key regulatory proteins in pediatric B-cell lymphomas is necessary for revealing the complex molecular background of this disease.},
  author       = {Fridberg, Marie and Kjellström, Sofia and Anagnostaki, Lola and Skogvall, Ingela and Mustelin, Tomas and Wiebe, Thomas and Persson, Jenny L and Dictor, Michael and Gjörloff Wingren, Anette},
  issn         = {1521-0669},
  language     = {eng},
  number       = {6},
  pages        = {528--540},
  publisher    = {Hemisphere Pub. Corp.},
  series       = {Pediatric Hematology & Oncology},
  title        = {Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls.},
  url          = {http://dx.doi.org/10.1080/08880010802237054},
  volume       = {25},
  year         = {2008},
}