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Vagotomy and accompanying pyloroplasty down-regulates ghrelin mRNA but does not affect ghrelin secretion.

Erlanson-Albertsson, Charlotte LU and Lindqvist, Andreas LU (2008) In Regulatory Peptides 151. p.14-18
Abstract
In this study, we have examined how the lack of vagus activity affects the long-term secretion of total and active ghrelin. We subjected mice to sham-operation, pyloroplasty or vagotomy and pyloroplasty. The study lasted for 2 weeks, during which body weight development and daily food intake was monitored. At the end of the study, the mice were sacrificed, and serum and fundus were collected. Measurements of total and active serum ghrelin revealed no difference between the surgical groups and sham-operated mice, despite the fact that fundic ghrelin mRNA was down-regulated. The results presented here suggest that the vagus activity is not required for the long-term secretion of neither total nor active ghrelin in mice. They also suggest... (More)
In this study, we have examined how the lack of vagus activity affects the long-term secretion of total and active ghrelin. We subjected mice to sham-operation, pyloroplasty or vagotomy and pyloroplasty. The study lasted for 2 weeks, during which body weight development and daily food intake was monitored. At the end of the study, the mice were sacrificed, and serum and fundus were collected. Measurements of total and active serum ghrelin revealed no difference between the surgical groups and sham-operated mice, despite the fact that fundic ghrelin mRNA was down-regulated. The results presented here suggest that the vagus activity is not required for the long-term secretion of neither total nor active ghrelin in mice. They also suggest that fundic ghrelin mRNA expression is affected by pyloroplasty and vagotomy but that this effect does not translate into changes in ghrelin levels in the circulation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Regulatory Peptides
volume
151
pages
14 - 18
publisher
Elsevier
external identifiers
  • wos:000261813500003
  • pmid:18804492
  • scopus:56249125931
ISSN
1873-1686
DOI
10.1016/j.regpep.2008.08.006
language
English
LU publication?
yes
id
43a146cc-95f4-4324-be2c-71f877d053a7 (old id 1242843)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18804492?dopt=Abstract
date added to LUP
2008-10-03 17:30:02
date last changed
2017-09-17 08:08:20
@article{43a146cc-95f4-4324-be2c-71f877d053a7,
  abstract     = {In this study, we have examined how the lack of vagus activity affects the long-term secretion of total and active ghrelin. We subjected mice to sham-operation, pyloroplasty or vagotomy and pyloroplasty. The study lasted for 2 weeks, during which body weight development and daily food intake was monitored. At the end of the study, the mice were sacrificed, and serum and fundus were collected. Measurements of total and active serum ghrelin revealed no difference between the surgical groups and sham-operated mice, despite the fact that fundic ghrelin mRNA was down-regulated. The results presented here suggest that the vagus activity is not required for the long-term secretion of neither total nor active ghrelin in mice. They also suggest that fundic ghrelin mRNA expression is affected by pyloroplasty and vagotomy but that this effect does not translate into changes in ghrelin levels in the circulation.},
  author       = {Erlanson-Albertsson, Charlotte and Lindqvist, Andreas},
  issn         = {1873-1686},
  language     = {eng},
  pages        = {14--18},
  publisher    = {Elsevier},
  series       = {Regulatory Peptides},
  title        = {Vagotomy and accompanying pyloroplasty down-regulates ghrelin mRNA but does not affect ghrelin secretion.},
  url          = {http://dx.doi.org/10.1016/j.regpep.2008.08.006},
  volume       = {151},
  year         = {2008},
}