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Glycosylated Hemoglobin and Risk of Colorectal Cancer in Men and Women, the European Prospective Investigation into Cancer and Nutrition

Rinaldi, Sabina; Rohrmann, Sabine; Jenab, Mazda; Biessy, Carine; Sieri, Sabina; Palli, Domenico; Tumino, Rosario; Mattiello, Amalla; Vineis, Paolo and Nieters, Alexandra, et al. (2008) In Cancer Epidemiology Biomarkers & Prevention 17(11). p.3108-3115
Abstract
Although large-scale prospective cohort studies have related hyperglycemia to increased risk of cancer overall, studies specifically on colorectal cancer have been generally small. We investigated the association between prediagnostic levels of glycosylated hemoglobin (HbA1c), a marker for average glucose level in blood, and colorectal cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort. One thousand and twenty-six incident colorectal cancer cases (561 men and 465 women) and 1,026 matched controls were eligible for the study. Multivariate conditional logistic regression was used to estimate odds ratios (ORS) adjusted for possible confounders. Increasing HbA1c percentages... (More)
Although large-scale prospective cohort studies have related hyperglycemia to increased risk of cancer overall, studies specifically on colorectal cancer have been generally small. We investigated the association between prediagnostic levels of glycosylated hemoglobin (HbA1c), a marker for average glucose level in blood, and colorectal cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort. One thousand and twenty-six incident colorectal cancer cases (561 men and 465 women) and 1,026 matched controls were eligible for the study. Multivariate conditional logistic regression was used to estimate odds ratios (ORS) adjusted for possible confounders. Increasing HbA1c percentages were statistically significantly associated with a mild increase in colorectal cancer risk in the whole population [OR, 1.10; 95% confidence interval (CI), 1.01,1.19 for a 10% increase in HbA1c]. In women, increasing HbA1c percentages were associated with a statistically significant increase in colorectal cancer risk (OR, 1.16; 95% CI, 1.01, 1.32 for a 10% increase in HbA1c) and with a borderline statistically significant increase in rectum cancer (OR, 1.22; 95% CI, 0.99,1.50 for a 10% increase in HbA1c). No significant association with cancer risk was observed in men. The results of the current study suggest a mild implication of hyperglycemia in colorectal cancer, which seems more important in women than in men, and more for cancer of the rectum than of the colon. (Cancer Epidemiol Biomarkers Prev 2008;17(11):3108-15) (Less)
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Cancer Epidemiology Biomarkers & Prevention
volume
17
issue
11
pages
3108 - 3115
publisher
American Association for Cancer Research
external identifiers
  • wos:000260896500028
  • scopus:55849142261
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-08-0495
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English
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947410eb-3955-4f90-b59d-22ad7696ceb1 (old id 1283564)
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2009-02-10 10:47:18
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@article{947410eb-3955-4f90-b59d-22ad7696ceb1,
  abstract     = {Although large-scale prospective cohort studies have related hyperglycemia to increased risk of cancer overall, studies specifically on colorectal cancer have been generally small. We investigated the association between prediagnostic levels of glycosylated hemoglobin (HbA1c), a marker for average glucose level in blood, and colorectal cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort. One thousand and twenty-six incident colorectal cancer cases (561 men and 465 women) and 1,026 matched controls were eligible for the study. Multivariate conditional logistic regression was used to estimate odds ratios (ORS) adjusted for possible confounders. Increasing HbA1c percentages were statistically significantly associated with a mild increase in colorectal cancer risk in the whole population [OR, 1.10; 95% confidence interval (CI), 1.01,1.19 for a 10% increase in HbA1c]. In women, increasing HbA1c percentages were associated with a statistically significant increase in colorectal cancer risk (OR, 1.16; 95% CI, 1.01, 1.32 for a 10% increase in HbA1c) and with a borderline statistically significant increase in rectum cancer (OR, 1.22; 95% CI, 0.99,1.50 for a 10% increase in HbA1c). No significant association with cancer risk was observed in men. The results of the current study suggest a mild implication of hyperglycemia in colorectal cancer, which seems more important in women than in men, and more for cancer of the rectum than of the colon. (Cancer Epidemiol Biomarkers Prev 2008;17(11):3108-15)},
  author       = {Rinaldi, Sabina and Rohrmann, Sabine and Jenab, Mazda and Biessy, Carine and Sieri, Sabina and Palli, Domenico and Tumino, Rosario and Mattiello, Amalla and Vineis, Paolo and Nieters, Alexandra and Linseisen, Jakob and Pischon, Tobias and Boeing, Heiner and Hallmans, Gran and Palmqvist, Richard and Manjer, Jonas and Wirfält, Elisabet and Crowe, Francesca L. and Khaw, Kay-Tee T. and Bingham, Sheila and Tjonneland, Anne and Olsen, Anja and Overvad, Kim and Lund, Eiliv and Skeie, Guri and Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine and de lauzon-Guillain, Blandine and Ardanaz, Eva and Jakszyn, Paula and Quiros, Jose Ramon and Chirlaque, Maria-Dolores and Sanchez, Maria-Jose and Dorronsoro, Miren and Trichopoulou, Antonia and LagioU, Pagona and Trichopouios, Dimitrious and Bueno-De-Mesquita, H. Bas and van Duijnhoven, Franzel J. B. and Peeters, Petra H. M. and Slimani, Nadia and Ferrari, Pietro and Byrnes, Graham B. and Riboli, Elio and Kaaks, Rudolf},
  issn         = {1538-7755},
  language     = {eng},
  number       = {11},
  pages        = {3108--3115},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Epidemiology Biomarkers & Prevention},
  title        = {Glycosylated Hemoglobin and Risk of Colorectal Cancer in Men and Women, the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1158/1055-9965.EPI-08-0495},
  volume       = {17},
  year         = {2008},
}