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Body Size and Risk of Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition

Pischon, Tobias; Boeing, Heiner; Weikert, Steffen; Allen, Naomi; Key, Tim; Johnsen, Nina Fons; Tjonneland, Anne; Severinsen, Marianne Tang; Overvad, Kim and Rohrmann, Sabine, et al. (2008) In Cancer Epidemiology Biomarkers & Prevention 17(11). p.3252-3261
Abstract
Background: Body size has been hypothesized to influence the risk of prostate cancer; however, most epidemiologic studies have relied on body mass index (BMI) to assess adiposity, whereas only a few studies have examined whether body fat distribution predicts prostate cancer. Methods: We examined the association of height, BMI, waist and hip circumference, and waist-hip ratio with prostate cancer risk among 129,502 men without cancer at baseline from 8 countries of the European Prospective Investigation into Cancer and Nutrition (EPIC), using Cox regression, with age as time metric, stratifying by study center and age at recruitment, and adjusting for education, smoking status, alcohol consumption, and physical activity. Results: During a... (More)
Background: Body size has been hypothesized to influence the risk of prostate cancer; however, most epidemiologic studies have relied on body mass index (BMI) to assess adiposity, whereas only a few studies have examined whether body fat distribution predicts prostate cancer. Methods: We examined the association of height, BMI, waist and hip circumference, and waist-hip ratio with prostate cancer risk among 129,502 men without cancer at baseline from 8 countries of the European Prospective Investigation into Cancer and Nutrition (EPIC), using Cox regression, with age as time metric, stratifying by study center and age at recruitment, and adjusting for education, smoking status, alcohol consumption, and physical activity. Results: During a mean follow-up of 8.5 years, 2,446 men developed prostate cancer. Waist circumference and waist-hip ratio were positively associated with risk of advanced disease. The relative risk of advanced prostate cancer was 1.06 (95% confidence interval, 1.01-1.1) per 5-cm-higher waist circumference and 1.21 (95% confidence interval, 1.04-1.39) per 0.1-unit-higher waist-hip ratio. When stratified by BMI, waist circumference and waist-hip ratio were positively related to risk of total, advanced, and high-grade prostate cancer among men with lower but not among those with higher BMI (P-interaction for waist with BMI, 0.25, 0.02, and 0.05, respectively; P-interaction for waist-hip ratio with BMI, 0.27, 0.22, and 0.14; respectively). Conclusions: These data suggest that abdominal adiposity may be associated with an increased risk of advanced prostate cancer. This association may be stronger among individuals with lower BMI; however, this finding needs confirmation in future studies. (Cancer Epidemiol Biomarkers Prev 2008;17(11):3252-61) (Less)
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Cancer Epidemiology Biomarkers & Prevention
volume
17
issue
11
pages
3252 - 3261
publisher
American Association for Cancer Research
external identifiers
  • wos:000260896500046
  • scopus:55849092876
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-08-0609
language
English
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01e2df8d-8a38-4858-b24e-f32cec10cfe1 (old id 1283611)
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2009-02-10 10:18:10
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@article{01e2df8d-8a38-4858-b24e-f32cec10cfe1,
  abstract     = {Background: Body size has been hypothesized to influence the risk of prostate cancer; however, most epidemiologic studies have relied on body mass index (BMI) to assess adiposity, whereas only a few studies have examined whether body fat distribution predicts prostate cancer. Methods: We examined the association of height, BMI, waist and hip circumference, and waist-hip ratio with prostate cancer risk among 129,502 men without cancer at baseline from 8 countries of the European Prospective Investigation into Cancer and Nutrition (EPIC), using Cox regression, with age as time metric, stratifying by study center and age at recruitment, and adjusting for education, smoking status, alcohol consumption, and physical activity. Results: During a mean follow-up of 8.5 years, 2,446 men developed prostate cancer. Waist circumference and waist-hip ratio were positively associated with risk of advanced disease. The relative risk of advanced prostate cancer was 1.06 (95% confidence interval, 1.01-1.1) per 5-cm-higher waist circumference and 1.21 (95% confidence interval, 1.04-1.39) per 0.1-unit-higher waist-hip ratio. When stratified by BMI, waist circumference and waist-hip ratio were positively related to risk of total, advanced, and high-grade prostate cancer among men with lower but not among those with higher BMI (P-interaction for waist with BMI, 0.25, 0.02, and 0.05, respectively; P-interaction for waist-hip ratio with BMI, 0.27, 0.22, and 0.14; respectively). Conclusions: These data suggest that abdominal adiposity may be associated with an increased risk of advanced prostate cancer. This association may be stronger among individuals with lower BMI; however, this finding needs confirmation in future studies. (Cancer Epidemiol Biomarkers Prev 2008;17(11):3252-61)},
  author       = {Pischon, Tobias and Boeing, Heiner and Weikert, Steffen and Allen, Naomi and Key, Tim and Johnsen, Nina Fons and Tjonneland, Anne and Severinsen, Marianne Tang and Overvad, Kim and Rohrmann, Sabine and Kaaks, Rudolf and Trichopoulou, Antonia and Zoi, Gitaki and Trichopoulos, Dimitrios and Pala, Valeria and Palli, Domenico and Tumino, Rosario and Sacerdote, Carlotta and Bueno-de-Mesquita, H. Bas and May, Anne and Manjer, Jonas and Wallström, Peter and Stattin, Par and Hallmans, Goran and Buckland, Genevieve and Larranaga, Nerea and Dolores Chirlaque, Maria and Martinez, Carmen and Redondo Cornejo, Maria L. and Ardanaz, Eva and Bingham, Sheila and Khaw, Kay-Tee and Rinaldi, Sabina and Slimani, Nadia and Jenab, Mazda and Riboli, Elio},
  issn         = {1538-7755},
  language     = {eng},
  number       = {11},
  pages        = {3252--3261},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Epidemiology Biomarkers & Prevention},
  title        = {Body Size and Risk of Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1158/1055-9965.EPI-08-0609},
  volume       = {17},
  year         = {2008},
}