Lower incidence of procoagulant abnormalities during follow-up after creation of the Fontan circulation in children.
Rask, Olof LU ; Hanséus, Katarina LU ; Ljung, Rolf LU
; Strandberg, Karin
LU
and Berntorp, Erik
LU
(2009)
In Cardiology in the Young
19.
p.152-158
- Abstract
- OBJECTIVE: Children who undergo surgery for complex congenital cardiac disease are reported to be at increased thrombotic risk. Our aim was to evaluate long-term changes in the haemostatic system after surgery, to compare markers of activated coagulation in children having surgery with those in a healthy control population, and to relate them to adverse clinical outcome.Patients and methodsWe studied, prior to surgery, the coagulation profiles of a cohort of 28 children admitted for a modified Fontan operation, studying them again after a period of mean follow-up of 9.6 years. Median age at the time of final surgery was 18.5 months, with a range from 12 to 76 months. We compared generation of thrombin, and levels of the activated protein... (More)
- OBJECTIVE: Children who undergo surgery for complex congenital cardiac disease are reported to be at increased thrombotic risk. Our aim was to evaluate long-term changes in the haemostatic system after surgery, to compare markers of activated coagulation in children having surgery with those in a healthy control population, and to relate them to adverse clinical outcome.Patients and methodsWe studied, prior to surgery, the coagulation profiles of a cohort of 28 children admitted for a modified Fontan operation, studying them again after a period of mean follow-up of 9.6 years. Median age at the time of final surgery was 18.5 months, with a range from 12 to 76 months. We compared generation of thrombin, and levels of the activated protein C-protein C inhibitor complex to controls at follow-up. Thrombophilia and clinical outcome were evaluated. RESULTS: At long-term follow-up, a lower incidence of procoagulant abnormalities was observed compared to that before surgery. Of 27 patients, 3 (11%), but none of 45 controls, had levels of activated protein C-protein C inhibitor complex above the reference range. There were no significant differences in generation of thrombin between patients and controls. No thrombotic events were recorded, and the patients were generally in good clinical condition. CONCLUSIONS: Overall, haemostasis appeared to be in balance, and less prothrombotic, after surgery. A subset of the cohort did show indications of activated coagulation. The current therapeutic approach seems to be sufficient to protect the majority of patient. New tests of global coagulation, nonetheless, may be helpful in improving identification of individuals at increased thrombotic risk. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1302851
- author
- Rask, Olof
LU
; Hanséus, Katarina
LU
; Ljung, Rolf
LU
; Strandberg, Karin
LU
and Berntorp, Erik
LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cardiology in the Young
- volume
- 19
- pages
- 152 - 158
- publisher
- Cambridge University Press
- external identifiers
-
- wos:000264966700006
- pmid:19195416
- scopus:66149136876
- ISSN
- 1467-1107
- DOI
- 10.1017/S1047951109003503
- language
- English
- LU publication?
- yes
- id
- 6ee1cb39-c4bb-473a-a582-7de2d328b0bc (old id 1302851)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19195416?dopt=Abstract
- date added to LUP
- 2016-04-04 08:55:28
- date last changed
- 2022-02-28 05:49:22
@article{6ee1cb39-c4bb-473a-a582-7de2d328b0bc,
abstract = {{OBJECTIVE: Children who undergo surgery for complex congenital cardiac disease are reported to be at increased thrombotic risk. Our aim was to evaluate long-term changes in the haemostatic system after surgery, to compare markers of activated coagulation in children having surgery with those in a healthy control population, and to relate them to adverse clinical outcome.Patients and methodsWe studied, prior to surgery, the coagulation profiles of a cohort of 28 children admitted for a modified Fontan operation, studying them again after a period of mean follow-up of 9.6 years. Median age at the time of final surgery was 18.5 months, with a range from 12 to 76 months. We compared generation of thrombin, and levels of the activated protein C-protein C inhibitor complex to controls at follow-up. Thrombophilia and clinical outcome were evaluated. RESULTS: At long-term follow-up, a lower incidence of procoagulant abnormalities was observed compared to that before surgery. Of 27 patients, 3 (11%), but none of 45 controls, had levels of activated protein C-protein C inhibitor complex above the reference range. There were no significant differences in generation of thrombin between patients and controls. No thrombotic events were recorded, and the patients were generally in good clinical condition. CONCLUSIONS: Overall, haemostasis appeared to be in balance, and less prothrombotic, after surgery. A subset of the cohort did show indications of activated coagulation. The current therapeutic approach seems to be sufficient to protect the majority of patient. New tests of global coagulation, nonetheless, may be helpful in improving identification of individuals at increased thrombotic risk.}},
author = {{Rask, Olof and Hanséus, Katarina and Ljung, Rolf and Strandberg, Karin and Berntorp, Erik}},
issn = {{1467-1107}},
language = {{eng}},
pages = {{152--158}},
publisher = {{Cambridge University Press}},
series = {{Cardiology in the Young}},
title = {{Lower incidence of procoagulant abnormalities during follow-up after creation of the Fontan circulation in children.}},
url = {{http://dx.doi.org/10.1017/S1047951109003503}},
doi = {{10.1017/S1047951109003503}},
volume = {{19}},
year = {{2009}},
}