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Decreased UCP2 mRNA expression in rat stomach following vagotomy: novel role for UCP2 as free radical scavenger in the stomach?

Lindqvist, Andreas LU ; Mei, Jie LU ; Sundler, Frank LU and Erlanson-Albertsson, Charlotte LU (2004) In Nutritional Neuroscience 7(4). p.217-222
Abstract
Uncoupling protein 2 (UCP2) is a protein, located in the inner mitochondrial membrane, which dissipates the proton gradient of this membrane and uncouples respiration from oxidative phosphorylation. We found, by in situ hybridisation, UCP2 mRNA to be located in the proliferating zone of the mucous neck cells in the fundus part of the rat stomach. We also found that UCP2 expression in fundus was significantly decreased after seven days of vagotomy. Furthermore, we found manganese-containing superoxide dismutase (SOD2), in fundus, to be down-regulated in a way similar to UCP2. The amount of ATP was significantly decreased following vagotomy. It is concluded that UCP2 in the gastro-intestinal tract is regulated through vagal innervation and... (More)
Uncoupling protein 2 (UCP2) is a protein, located in the inner mitochondrial membrane, which dissipates the proton gradient of this membrane and uncouples respiration from oxidative phosphorylation. We found, by in situ hybridisation, UCP2 mRNA to be located in the proliferating zone of the mucous neck cells in the fundus part of the rat stomach. We also found that UCP2 expression in fundus was significantly decreased after seven days of vagotomy. Furthermore, we found manganese-containing superoxide dismutase (SOD2), in fundus, to be down-regulated in a way similar to UCP2. The amount of ATP was significantly decreased following vagotomy. It is concluded that UCP2 in the gastro-intestinal tract is regulated through vagal innervation and suggested to act as a free radical scavenger. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ATP, SOD2, UCP2, Vagotomy
in
Nutritional Neuroscience
volume
7
issue
4
pages
217 - 222
publisher
Taylor & Francis
external identifiers
  • wos:000226385100004
  • pmid:15682648
  • scopus:12344292357
ISSN
1476-8305
DOI
10.1080/10284150400011390
language
English
LU publication?
yes
id
52d46fc7-27cd-47f0-86f9-bc3f9c723ee1 (old id 133984)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15682648&dopt=Abstract
date added to LUP
2007-07-17 08:33:46
date last changed
2017-05-28 03:39:19
@article{52d46fc7-27cd-47f0-86f9-bc3f9c723ee1,
  abstract     = {Uncoupling protein 2 (UCP2) is a protein, located in the inner mitochondrial membrane, which dissipates the proton gradient of this membrane and uncouples respiration from oxidative phosphorylation. We found, by in situ hybridisation, UCP2 mRNA to be located in the proliferating zone of the mucous neck cells in the fundus part of the rat stomach. We also found that UCP2 expression in fundus was significantly decreased after seven days of vagotomy. Furthermore, we found manganese-containing superoxide dismutase (SOD2), in fundus, to be down-regulated in a way similar to UCP2. The amount of ATP was significantly decreased following vagotomy. It is concluded that UCP2 in the gastro-intestinal tract is regulated through vagal innervation and suggested to act as a free radical scavenger.},
  author       = {Lindqvist, Andreas and Mei, Jie and Sundler, Frank and Erlanson-Albertsson, Charlotte},
  issn         = {1476-8305},
  keyword      = {ATP,SOD2,UCP2,Vagotomy},
  language     = {eng},
  number       = {4},
  pages        = {217--222},
  publisher    = {Taylor & Francis},
  series       = {Nutritional Neuroscience},
  title        = {Decreased UCP2 mRNA expression in rat stomach following vagotomy: novel role for UCP2 as free radical scavenger in the stomach?},
  url          = {http://dx.doi.org/10.1080/10284150400011390},
  volume       = {7},
  year         = {2004},
}