Decreased UCP2 mRNA expression in rat stomach following vagotomy: novel role for UCP2 as free radical scavenger in the stomach?
(2004) In Nutritional Neuroscience 7(4). p.217-222- Abstract
- Uncoupling protein 2 (UCP2) is a protein, located in the inner mitochondrial membrane, which dissipates the proton gradient of this membrane and uncouples respiration from oxidative phosphorylation. We found, by in situ hybridisation, UCP2 mRNA to be located in the proliferating zone of the mucous neck cells in the fundus part of the rat stomach. We also found that UCP2 expression in fundus was significantly decreased after seven days of vagotomy. Furthermore, we found manganese-containing superoxide dismutase (SOD2), in fundus, to be down-regulated in a way similar to UCP2. The amount of ATP was significantly decreased following vagotomy. It is concluded that UCP2 in the gastro-intestinal tract is regulated through vagal innervation and... (More)
- Uncoupling protein 2 (UCP2) is a protein, located in the inner mitochondrial membrane, which dissipates the proton gradient of this membrane and uncouples respiration from oxidative phosphorylation. We found, by in situ hybridisation, UCP2 mRNA to be located in the proliferating zone of the mucous neck cells in the fundus part of the rat stomach. We also found that UCP2 expression in fundus was significantly decreased after seven days of vagotomy. Furthermore, we found manganese-containing superoxide dismutase (SOD2), in fundus, to be down-regulated in a way similar to UCP2. The amount of ATP was significantly decreased following vagotomy. It is concluded that UCP2 in the gastro-intestinal tract is regulated through vagal innervation and suggested to act as a free radical scavenger. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/133984
- author
- Lindqvist, Andreas LU ; Mei, Jie LU ; Sundler, Frank LU and Erlanson-Albertsson, Charlotte LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ATP, SOD2, UCP2, Vagotomy
- in
- Nutritional Neuroscience
- volume
- 7
- issue
- 4
- pages
- 217 - 222
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000226385100004
- pmid:15682648
- scopus:12344292357
- pmid:15682648
- ISSN
- 1476-8305
- DOI
- 10.1080/10284150400011390
- language
- English
- LU publication?
- yes
- id
- 52d46fc7-27cd-47f0-86f9-bc3f9c723ee1 (old id 133984)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15682648&dopt=Abstract
- date added to LUP
- 2016-04-01 12:02:55
- date last changed
- 2022-02-03 08:52:35
@article{52d46fc7-27cd-47f0-86f9-bc3f9c723ee1, abstract = {{Uncoupling protein 2 (UCP2) is a protein, located in the inner mitochondrial membrane, which dissipates the proton gradient of this membrane and uncouples respiration from oxidative phosphorylation. We found, by in situ hybridisation, UCP2 mRNA to be located in the proliferating zone of the mucous neck cells in the fundus part of the rat stomach. We also found that UCP2 expression in fundus was significantly decreased after seven days of vagotomy. Furthermore, we found manganese-containing superoxide dismutase (SOD2), in fundus, to be down-regulated in a way similar to UCP2. The amount of ATP was significantly decreased following vagotomy. It is concluded that UCP2 in the gastro-intestinal tract is regulated through vagal innervation and suggested to act as a free radical scavenger.}}, author = {{Lindqvist, Andreas and Mei, Jie and Sundler, Frank and Erlanson-Albertsson, Charlotte}}, issn = {{1476-8305}}, keywords = {{ATP; SOD2; UCP2; Vagotomy}}, language = {{eng}}, number = {{4}}, pages = {{217--222}}, publisher = {{Taylor & Francis}}, series = {{Nutritional Neuroscience}}, title = {{Decreased UCP2 mRNA expression in rat stomach following vagotomy: novel role for UCP2 as free radical scavenger in the stomach?}}, url = {{http://dx.doi.org/10.1080/10284150400011390}}, doi = {{10.1080/10284150400011390}}, volume = {{7}}, year = {{2004}}, }